Original Article
Dehghani Leila; Khanjani Narges; Bahrampour Abbas
Volume 15, Issue 4 , 2012, Pages 111-116
Abstract
Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof ...
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Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof skin cancer was determined in Kerman province where islocated in the desert region of Iran with ample sunlight, duringa 5–year period.Method: All registered cases of skin cancers between March2005 and March 2010 were retrieved from the Kerman ProvinceCancer Registry. For each patient, data about age, gender,location, pathologic type of cancer and site of skin involvement,were obtained. Incidence rates according to the age, sex and thelocation of the lesions were calculated. Trend analysis was donefor the next 10 years.Result: During these 5 years, 1250 cases of skin cancer wererecorded. The incidence in men was 1.2 times higher than women.The highest incidence was seen in individulas older than 80 yearsof age. Fifty percent of all skin cancers were located on the face.The highest incidence was observed in the city of Kerman withan annual incidence of 12.6 in 100,000. Trend analysis showedthat the incidence of skin cancer in Kerman province would reach23 in 100 000 people in 2019, which is 2.3 times higher than theincidence rate in 2009.Conclusion: Skin cancer is a public health concern in Kermanprovince in Iran. Considering the desert climate and the intensity ofsunlight in most seasons, it is necessary to plan scientific practicalinterventions to prevent skin cancer and reduce its incidence..
Original Article
Seirafi Hassan; Ehsani Amirhooshang; Jesri Shabboo; Gholamali Fatemeh; Noormohammadpour Pedram
Volume 15, Issue 4 , 2012, Pages 117-121
Abstract
Background: Infantile hemangioma is a congenital vascularmalformation. Although almost all cases are self-limiting, treatmentis sometimes necessary. According to previous studies, topicalimiquimod induces resolution of lesions with an acceptable safetyprofile. The aim of the present study was to evaluate ...
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Background: Infantile hemangioma is a congenital vascularmalformation. Although almost all cases are self-limiting, treatmentis sometimes necessary. According to previous studies, topicalimiquimod induces resolution of lesions with an acceptable safetyprofile. The aim of the present study was to evaluate the effect ofthis topical treatment on Iranian infantile hemangioma patients.Method: Patients under two years of age with infantile hemangiomawho were not candidates for immediate systemic therapy withsteroids were selected if the lesions were not ulcerated. Topical5% imiquimod was applied on the lesions for 16 weeks. All thelesions were photographed before the commencement of the studyand at the end of the treatment. Photographs were compared bytwo associate dermatology professors to evaluate the effect oftreatment using a visual analogue scale.Result: A total of 15 patients including five males (33.3%) andten females (66.7%), with an age range of two to 18 months anda mean age of 9.1 (± 6.3) months, were enrolled in the study.The mean diameter of the lesions was 2.6 cm (± 1.8 cm). Ninepatients (60%) had moderate response and five patients (33.3%)had good response while one patient had excellent response.Complications were mild local irritation and pruritus.Conclusion: It seems that topical imiquimod could be a suitableoption in the treatment of some infantile hemangioma lesions notcandidate for systemic treatment and/or other local measuressuch as laser and intra lesional steroid or when other drugs areuseless or harmful..
Original Article
Talat Humaira; Wahid Zarnaz; Mirza Reema
Volume 15, Issue 4 , 2012, Pages 122-126
Abstract
Background: This study was conducted because up to now,the investigations performed on cutaneous manifestations ofantihypertensive agents’ reactions, especially in Pakistan, arenegligible even though these drugs are taken by a large numberof people. The aim of this study was to determine the cutaneousmanifestations ...
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Background: This study was conducted because up to now,the investigations performed on cutaneous manifestations ofantihypertensive agents’ reactions, especially in Pakistan, arenegligible even though these drugs are taken by a large numberof people. The aim of this study was to determine the cutaneousmanifestations of different antihypertensive agents in terms ofdosage and duration.Method: The study was carried out at the Departments ofDermatology and Cardiology, Civil Hospital, Karachi. The studywas carried out from June 2007 to December 2007. The inclusioncriteria included all patients taking a single antihypertensive agentwith cutaneous manifestations. Patients taking antihypertensivedrugs but suffering from some other dermatological diseases andthose taking more than one drug were excluded. After informedconsent, history, specifically regarding the type of drug dosageand duration of drug intake was taken. Specific investigationssuch as biopsy were done if indicated.Result: Out of 100 patients, 37 were male and 63 were female.Most of the patients were in the age group 46–60 years. Themajority (97%) of patients experienced the onset of lesions between4–8 weeks of therapy and only 2% had lesions within 4 weeks.Moderate lesions were markedly more common and were foundin 65% followed by mild lesions in 26%, severe in 6%, and lethalin 3% of the patients. The most common lesions were pruritisand eczema, followed by flushing, lichenoid eruptions, oralulcers, purpuras, psoriasis, exanthematous reactions, urticaria,gingival hyperplasia, lichen planus, morbilliform rashes, orallichen planus and butterfly rash.Conclusion: No relation was noted between a drug dose andthe severity of skin lesions. Most patients started having skinlesions 4 to 8 weeks after therapy..
Original Article
Zahra Fazel; Mahnaz Banihashemi; Mohammad-Javad Yazdanpanah; Hadis Yousefzadeh
Volume 15, Issue 4 , 2012, Pages 127-130
Abstract
Background: Various kinds of sensitizers are administrated foralopecia areata treatment. The aim of this study was to evaluatetreatment response to Dinitrochlorobenzene (DNCB) in alopeciaareata patients.Method: In this study, 117 patients were treated with DNCBunder a specific checklist. All patients ...
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Background: Various kinds of sensitizers are administrated foralopecia areata treatment. The aim of this study was to evaluatetreatment response to Dinitrochlorobenzene (DNCB) in alopeciaareata patients.Method: In this study, 117 patients were treated with DNCBunder a specific checklist. All patients were sensitized with a 2%DNCB and then treated with ascending DNCB concentrations(0.001%-2%). Response to treatment was categorized as none,mild, moderate and marked improvement.Result: Thirty three (27.5%) patients showed no response, 49(40.8%) had relapse 6 months after improvement, 29 (24.2%)had no relapse 6 months after the treatment and 6 patientswere excluded because they did not return for follow-up visits.Response to treatment in patients without eyelash and eyebrowinvolvement increased significantly (P=0.01). We did not observeany side effects except for localized dermatitis seen in 5% of thepatients.Conclusion: With respect to the suitable response to DNCBapplication and its availability, the authors suggest that DNCBbe reconsidered in alopecia areata. However, attention must bepaid to its mutagenicity..
Case Report
Popat Vijay; Vora Deval; Patel Pratik; Maan Pratibha; Brahmbhatt Vinita
Volume 15, Issue 4 , 2012, Pages 131-133
Abstract
Ehlers-Danlos syndrome (EDS) is a clinically heterogeneous groupof inherited disorders with ten different types, all involving agenetic defect in collagen and connective-tissue synthesis andstructure that affecting the skin, joints, and blood vessels. EDStype VIA, a very rare kyphoscoliotic type, is ...
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Ehlers-Danlos syndrome (EDS) is a clinically heterogeneous groupof inherited disorders with ten different types, all involving agenetic defect in collagen and connective-tissue synthesis andstructure that affecting the skin, joints, and blood vessels. EDStype VIA, a very rare kyphoscoliotic type, is autosomal recessiveand clinically characterized by soft extensible skin, laxity ofjoints and kyphoscoliosis. We present a case of an adult malepatient complaining of recurrent acne over the chin, axilla andpyoderma in the groin region since he was 14 years of age. Pastmedical history was positive for recurrent pyoderma whichhealed with scarring, bleeding tendency, double vision andbackache. On examination, the patient had hyperextensible skin,joint hypermobility, kyphoscoliosis, easy bruisability, and scleralfragility. Urinary analysis revealed a decrease in the hydroxylysylpyidinolineto lysl-pyridinoline ratio indicative of EDS type VIAwith a severely reduced Lysyl Hydroxylase (LH) activity in theskin fibroblast culture..
Case Report
Pedram Noormohammadpour; Somayeh Khezri; Zahra Safaee Naraghi; Alireza Ghanadan; Farzaneh Khezri
Volume 15, Issue 4 , 2012, Pages 134-136
Abstract
Confluent and Reticulate Papillomatosis (CRP) is a rare disease withpoorly recognized etiology. Various agents such as antibacterial,topical/systemic antifungal and topical/oral retinoids have beenused as treatment. Here, we report a 15-year-old female withCRP in whom yeasts of Malassezia were found ...
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Confluent and Reticulate Papillomatosis (CRP) is a rare disease withpoorly recognized etiology. Various agents such as antibacterial,topical/systemic antifungal and topical/oral retinoids have beenused as treatment. Here, we report a 15-year-old female withCRP in whom yeasts of Malassezia were found in the PAS stainof the skin lesions. Topical terbinafine hydrochloride 1% sprayand oral fluconazole disappeared the lesions, supporting thehypothesis that CRP maybe a reactive dermatosis to Malassezia..
Case Report
Maryam Emad; Fatemeh Sari Aslani; Nasrin Saki; Dorna Motevalli; Forugh Saki
Volume 15, Issue 4 , 2012, Pages 137-140
Abstract
Diffuse normolipemic plane xanthoma is characterized by thepresence of yellowish-orange plaques on the eyelids, neck, uppertrunk, buttocks and flexural surfaces of the extremities in patientswith a normal lipid profile. It mainly affects adults of both sexes.Diffuse normolipemic plane xanthomas are usually ...
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Diffuse normolipemic plane xanthoma is characterized by thepresence of yellowish-orange plaques on the eyelids, neck, uppertrunk, buttocks and flexural surfaces of the extremities in patientswith a normal lipid profile. It mainly affects adults of both sexes.Diffuse normolipemic plane xanthomas are usually associatedwith reticuloendothelial system disorders, such as multiplemyeloma and monoclonal gammopathies. We report a case ofdiffuse plane xanthomas in an otherwise healthy 1-year-old maleinfant who developed multiple disseminated non-inflammatoryyellowish-orange macules and patches that were not associatedwith any other symptoms..
Quiz
Mortazavi Hossein; Abdolreza Mona; Nikoo Azita
Volume 15, Issue 4 , 2012, Pages 141-143
Letter to Editor
Salmanpoor Rahmatollah; Saki Nasrin; Mahmoodi Gholamreza
Volume 15, Issue 4 , 2012, Pages 144-145
