Original Article
Tafti Hossein Sadeghi; Ahmadikia Kazem; Rashidian Sara; Hekmatimoghaddam Seyed Hossein; Yazdi Zeinab Ayubi
Volume 20, Issue 2 , 2017, Pages 37-42
Abstract
Background: Onychomycosis, the fungal infection of the toenails or fingernails, is caused by three major groups of fungi including dermatophytes, yeasts and non-dermatophyte molds. The objective of the present study was to determine the incidence of onychomycosis and to identify the causative fungi during ...
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Background: Onychomycosis, the fungal infection of the toenails or fingernails, is caused by three major groups of fungi including dermatophytes, yeasts and non-dermatophyte molds. The objective of the present study was to determine the incidence of onychomycosis and to identify the causative fungi during a one year period in Yazd, Iran. Materials and Methods: From Apr 2013 to Apr 2014 a total of 273 patients with suspected dermatophytosis were included in this study. Nail-clipping specimens of 71 clinically diagnosed cases of onychomycosis were obtained for mycological examination (KOH preparation and fungal culture). Identification of mycelial isolates was based on morphological appearance and microscopic characteristic of the colony. Supplementary methods for identification of dermatophytes were employed. The species of yeasts were identified by germ-tube and chlamydospore test, as well as colony color on chromogenic CHROMagar Candida medium, and the assimilation profile in API 20C Aux system. Results: Of the 71 patients affected by nail disorders, 26 (36.6%) patients of onychomycosis including 54.9% male and 45.1% female (20 fingernails, 6 toenails) via direct examination and/or culture methods were diagnosed. saprophytic fungi were the most prevailing causative agents of onychomycosis and account for up to 69.2%(n=18) of cases, yeasts and dermatophytes were identified as causative agents of onychomycosis in 7 (26.9%) patients and 1 patient (3.8%), respectively. Distribution of fungal isolates was as follows: Aspergillus niger (26.9%), A. fumigatus (19.2%), Candida albicans (15.3%), A. flavus (11.5%), C. tropicalis (7.6%), Penicillium sp. (7.6%), C. dubliniensis (3.8%), Trichophyton mentagrophytes (3.8%) and Fusarium sp. (3.8%). Conclusion: Because of considerable prevalence of onychomycosis, necessity for a careful mycological examination in patients with nail disorders is highlighted.
Parekh Niyati; Bhatia Kailash; Dayal Satguru; Kataria Rajesh; Lokwani Hitesh; Goyal Gagan; Sharma Rini; Syed Amin; Bhatia Jushya; Sarin Ankur; Bhatia Lavin
Volume 20, Issue 2 , 2017, Pages 43-49
Abstract
Background: Autologous serum skin test (ASST) evaluates the presence of any serum histamine-releasing factors and histamine-releasing autoantibodies. Autologous serum therapy (AST) is a therapy in which repeated injections of autologous serum are administered intramuscularly for treatment of chronicspontaneous ...
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Background: Autologous serum skin test (ASST) evaluates the presence of any serum histamine-releasing factors and histamine-releasing autoantibodies. Autologous serum therapy (AST) is a therapy in which repeated injections of autologous serum are administered intramuscularly for treatment of chronicspontaneous urticaria (CSU). The aim of this study is to evaluate the advantages and compare the results of the ASST and the efficacy of AST in CSU patients.Methods: We included a total of 39 patients that presented with urticaria of more than 6 weeks duration in this study. Patients who suffered from acute urticaria, urticarial vasculitis, physical urticaria, and other systemic diseases known to cause urticaria were excluded. Standard tools and techniques were used to prepare autologous serum, injection of the serum, and interpretation of the results. The test result was implicated as positive and negative ASST.
Original Article
Siddalingappa Karjigi; Murthy Sambasiviah Chidambara; Herakal Kallappa; Deepika Madagondanahalli
Volume 20, Issue 2 , 2017, Pages 50-53
Abstract
Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify ...
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Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify the thyroidprofile, including thyroid autoantibodies, in patients with CU.Methods: This case-control study included 100 patients with CU and 100 controls without urticaria. Males and females (age range: 20-40 years) who attended the Navodaya Medical College Hospital and Research centre were included. Participants underwent laboratory investigations that consisted of a complete blood count(CBC) thyroid autoantibodies, and other relevant investigations. Results: Patients in the CU group had a male to female ratio of 1:2.1 and a mean age of 31.2 years. The control group had a male to female ratio of 1:1 and a mean age of 35 years. Antimicrosomal antibodies (AMA) were present in 14 (14%) patients, 13 females and 1 male. There were no autoantibodies in any of the control group participants. Among these 14 patients, 5 (35.71%) had elevated serum thyroid stimulating hormone (TSH) and one had coexistent anti-thyroglobulin antibodies. Other associated diseases included diabetes mellitus, human immunodeficiency virus (HIV), and hepatitis B surface antigen (HBsAg) in onepatient each.Conclusion: Thyroid autoantibodies may play a role in persistent CU. Screening patients with persistent CU for thyroid functions, including thyroid autoantibodies, may help with proper management.
Original Article
Edalatkhah Hassan; Matin Elmira; Ahari Saeid Sadeghieh
Volume 20, Issue 2 , 2017, Pages 54-58
Abstract
Background: Acne vulgaris has a multifactorial pathogenesis; however, the exact role of genetic predisposition is not clear. Some studies have reported an association between familiy historyof acne and moderate to severe acne. In this study, we investigated the relationship between familiy history and ...
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Background: Acne vulgaris has a multifactorial pathogenesis; however, the exact role of genetic predisposition is not clear. Some studies have reported an association between familiy historyof acne and moderate to severe acne. In this study, we investigated the relationship between familiy history and prevalence of acne vulgaris in girls 8 to 13 years of age.Methods: This case-control study enrolled 400 students. The participants were divided into two groups, case and control, with 200 students per group. The case group consisted of students with acne vulgaris and the control group included those without acne. The severity of acne was determined based on the Global AcneGrading Score (GAGS). The presence of acne in close relatives (father, mother, sister, brother) was determined through face to face interviews with participants’ mothers and phone contacts with other family members. All collected data were analyzed by SPSS software.Results: The case participants had a mean age of 10.62±1.71 years and those in the control group had a mean age of 10.54±1.70 years, which was not statistically significant. The mothers with acne vulgaris had the highest odds ratio (OR: 2.719, 95% CI: 1.788-4.133) between the case and the control groups. The ratio of encountering the probability with both parents developing acne vulgaris between the two groups was 2.346 (95% CI: 1.571-3.503).Conclusion: This study revealed a significant relationship between positive familial history of acne and prevalence of acne vulgaris.
Case Report
Maryam Nasimi; Arghavan Azizpour; Robabeh Abedini; Alireza Ghanadan
Volume 20, Issue 2 , 2017, Pages 59-62
Abstract
Morphea is an autoimmune connective tissue disease of the dermis and subcutaneous fat characterized by sclerosis due to excessive collagen deposition. Morphea is classified into different subtypes based on clinical and histological characteristics of cutaneous lesions. An extremely rare subtype of morphea ...
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Morphea is an autoimmune connective tissue disease of the dermis and subcutaneous fat characterized by sclerosis due to excessive collagen deposition. Morphea is classified into different subtypes based on clinical and histological characteristics of cutaneous lesions. An extremely rare subtype of morphea is termed unilateral generalized morphea (UGM). UGM is characterized by indurated plaques on dermatomes of the trunk or back with a sharp midline demarcation line. Ipsilateral limbs may also be affected. There is still debate on whether this type of morphea should be considered as a distinct type or a presentation of linear morphea. Here we report the case of an 8-year-old boy with this type of morphea.
Letter to Editor
Ramezani Mazaher; Danaei Samane; Sadeghi Masoud
Volume 20, Issue 2 , 2017, Pages 63-64
Letter to Editor
Alizadeh Ismaeil; Jahanifard Elham; Sharififard Mona
Volume 20, Issue 2 , 2017, Pages 65-67
