MJ Nazemi; S Sotoodeh; H Moslehi
Volume 6, Issue 2 , 2003, Pages 5-13
Abstract
Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The ...
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Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The clinical, Paraclinical and pathological findings in 50 biopsy proven patients with DLE referred to Razi Hospital in Tehran in 1377 were recorded in special questionnaires. Data were analyzed by SPSS software, T-Student and chi-square tests were used. Results: The number of female patients was twice of males, majority in the age range of 20 to 50 years, Most of the patients had no complaints except for skin eruptions. Paraclinical abnormalities were rare. The paraclinical changes were various, but hydropic degeneration of basal layer was found in all cases. Conclusion: Complementary studies are suggested to evaluate similarities and differences in Iranian and non-Iranian patients with DLE.
H Edalat Khah; M Mirza Namadi
Volume 6, Issue 2 , 2003, Pages 14-19
Abstract
Background: Melasma is the acquired, gradual and symmetric hyper pigmentation of the face. Melasma has been related to many factors such as pregnancy, genetic, endocrine and sun exposure but the exact relationship to endocrine factors isn’t still clear. Objectives: To evaluate the relationship ...
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Background: Melasma is the acquired, gradual and symmetric hyper pigmentation of the face. Melasma has been related to many factors such as pregnancy, genetic, endocrine and sun exposure but the exact relationship to endocrine factors isn’t still clear. Objectives: To evaluate the relationship between melasma and polycystic ovarian disease and androgenic hormones. Patients and Methods: This case-control study was performed on 101 patients with melasma and 101 control patients referred to the skin clinic of Ardebil University of Medical Sciences. Serum levels of LH, FSH, DHEAS, prolactin, testosterone and 17-hydroxy progesterone were measured and sonography of ovaries was done. Results: The age of the study subjects ranged from 15 to 45 years. There was no significant difference in serum levels of any of hormones between cases and control groups (P<0.05). Ovarian cysts were found in 65.3% of melasma patients and 47.5% of control patients (P=0.01). Conclusion: These results confirm the possible role of ovarian cysts or another common etiologic factor in melasma. More studies are required in this subject.
MJ Yazdan Panah; SK Mostoufi; M Soleimani
Volume 6, Issue 2 , 2003, Pages 20-24
Abstract
Background: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis (CL), but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance, adverse effects and low compliance of patient, ...
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Background: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis (CL), but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance, adverse effects and low compliance of patient, efforts for finding a more effective and safer drug continue. Objectives: To evaluate the efficacy of oral zinc sulfate in the treatment of acute dry CL. Patients and Methods: 31 patients with clinical diagnosis of acute, dry CL and positive direct smear for Leishman bodies were included in the trial. Patients were treated with 10 mg/kg/day oral zinc sulfate for 45 days and evaluated every 3 weeks during the period of treatment and also 1.5 months after cessation of it. Results: 22 patients completed the course of treatment. At the end of 45 days of treatment, only two cases (9%) were cured and the remaining did not show satisfactory response. Conclusion: Oral zinc sulfate has limited therapeutic value in the treatment of dry CL.
A Asilian; A Sadeghinia; F Shariati; SM Emam Jome; AR Ghoddusi
Volume 6, Issue 2 , 2003, Pages 25-29
Abstract
Background: Some researchers claim that permethrin-impregnated clothes are effective in the prevention of cutaneous leishmaniasis. Objectives: To determine the effectiveness of permethrin-impregnated clothes in the prevention of cutaneous leishmaniasis. Patients and Methods: 272 soldiers were randomized ...
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Background: Some researchers claim that permethrin-impregnated clothes are effective in the prevention of cutaneous leishmaniasis. Objectives: To determine the effectiveness of permethrin-impregnated clothes in the prevention of cutaneous leishmaniasis. Patients and Methods: 272 soldiers were randomized in two groups. In one group permethrin-impregnated clothes and in the other group, control clothes were used. In each group the clothes were worn during days and nights for three months and the soldiers were followed for additional 6 months. Results: 9 (6.5%) of 138 soldiers wearing control clothes and 6 (4.4%) of 134 soldiers wearing permethrin-impregnated clothes acquired cutaneous leishmaniasis. The difference between two groups was not statistically significant. Conclusion: Permethrin-impregnated clothes are not effective in the prevention of cutaneous leishmaniasis.
A Asilian; A Momeni; G Faghihi; V Sadeghi; M Sadeghi; H Sadeghi
Volume 6, Issue 2 , 2003, Pages 30-33
Abstract
Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by leishmania species. An ideal treatment for CL has not found yet. Objectives: To evaluate the efficacy of cryotherapy alone and combined with intralesional glucantime injection in the treatment of papulonodular CL. Patients and ...
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Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by leishmania species. An ideal treatment for CL has not found yet. Objectives: To evaluate the efficacy of cryotherapy alone and combined with intralesional glucantime injection in the treatment of papulonodular CL. Patients and Methods: 300 patients with CL were randomly assigned to two treatment groups in this clinical trial. In group 1, 100 patients with 149 lesions were treated with cryotherapy plus intralesional glucantime injection every 2 weeks. In group 2, 200 patients with 230 lesions were treated only with cryotherapy, every 2 weeks. Both groups were followed for 6 months after last treatment. Results: Clinical and parasitological cure were seen in 90% of cases in group 1 and 57.3% in group 2 (P<0.05). Conclusion: Combination of cryotherapy and intralesional glucantime injection is an effective treatment modality in early lesions of CL.
MA Nilforoosh Zadeh; MR Reiss Zadeh; F Jafari
Volume 6, Issue 2 , 2003, Pages 34-39
Abstract
Background: An easy and effective topical treatment is not yet available for cutaneous leishmaniasis. Objectives: To compare the effect of topical trichloroacetic acid (TCA) and intralesional glucantime injection in the treatment of acute wet cutaneous leishmaniasis. Patients and Methods: Eighty patients ...
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Background: An easy and effective topical treatment is not yet available for cutaneous leishmaniasis. Objectives: To compare the effect of topical trichloroacetic acid (TCA) and intralesional glucantime injection in the treatment of acute wet cutaneous leishmaniasis. Patients and Methods: Eighty patients with clinical diagnosis of wet cutaneous leishmaniasis in the age range of 5 to 75 years were recruited in this open clinical trial. Seven patients were withdrawn during the trial. In TCA group, 38 patients were treated three times (Every 2 weeks) with 50% TCA. In control group, 35 patients received intralesional glucantime injection weekly until healing or for a maximum of 6 weeks. All patients were followed for 3 months after last treatment. Results: After four weeks of treatment, 20 patients (52.6%) in TCA group and 17 patients (48.5%) in glucantime group, and after six weeks, 68% and 65.7% of patients in each respective group were completely cured. There was no important side effect in any groups. Conclusion: The nearly equal efficacy of TCA peeling and intralesional glucantime injection in the treatment of cutaneous leishmaniasis suggests that 50% TCA could be considered as a possible efficient therapeutic alternative in the management of this disease.
Z Pourpak; AR Ranjbar; AH Farhoodi; M Movahedi; A Koohkan
Volume 6, Issue 2 , 2003, Pages 40-52
Abstract
Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease with a prevalence of 10-20%. Recent studies suggested the effect of selenium on immunoregulation in AD. In this study we report 4 cases of atopic dermatitis according to Hafniin and Rajka criteria. Serum selenium levels were ...
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Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease with a prevalence of 10-20%. Recent studies suggested the effect of selenium on immunoregulation in AD. In this study we report 4 cases of atopic dermatitis according to Hafniin and Rajka criteria. Serum selenium levels were increased and serum total IgE were decreased in all patients. These results show that selenium is in the cells, therefore selenium could be a suitable and effective treatment. Further studies are required with increased subjects, different dosages and treatment duration to reach more definite results.
H Mortazavi; MJ Nazemi; N Zarinpour
Volume 6, Issue 2 , 2003, Pages 53-57
Abstract
Bloom syndrome is a rare autosomal recessive genetic disorder, which is characterized by telangiectasia and erythema in the butterfly area of the face, dwarfism and photosensitivity. The case presented herein is a 22-year-old man who referred with facial erythema and telangiectasia (Resembling lupus ...
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Bloom syndrome is a rare autosomal recessive genetic disorder, which is characterized by telangiectasia and erythema in the butterfly area of the face, dwarfism and photosensitivity. The case presented herein is a 22-year-old man who referred with facial erythema and telangiectasia (Resembling lupus erythematosus). The skin lesions were exacerbating during summer. Other clinical findings were proportionally short stature and bird-like facies, spots on the trunk. Chromosomal study was done which showed chromosome instabilities including gaps breaks, fragment and rearrangements in 90% of metaphases studies. Regarding to clinical findings and results of the chromosomal study, diagnosis of Bloom syndrome was established.
