Behzad Khodaei; Simin Seyedpour; Bahareh Gholami; Kambiz Kamyab Hesari; Seyed Ahmad Seyed Alinaghi; Maryam Nasimi
Abstract
Background: Nail disorders present with a wide range of manifestations. The problems associated with nail biopsiesmake the diagnosis even more challenging. Identifying the most common features of each nail disorder can prevent unnecessary biopsies and facilitate early diagnosis.Methods: We conducted ...
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Background: Nail disorders present with a wide range of manifestations. The problems associated with nail biopsiesmake the diagnosis even more challenging. Identifying the most common features of each nail disorder can prevent unnecessary biopsies and facilitate early diagnosis.Methods: We conducted a cross-sectional study on 528 pathology reports, documented from March 2018 to March 2019 in the Razi Dermatopathology Hospital, Tehran, Iran. We extracted the demographic data and the nails’ clinical and pathologic presentations. We used Fisher’s exact test to determine the nail features’ clinicopathological correlations.Results: The mean age of the 359 included patients was 38.81 ± 18.11 years, and 50.81% were male. Benign melanonychia (12.82%), traumatic nail (11.96%), and junctional nevus (11.11%) were the most prevalent disorders. Onycholysis (P < 0.001), longitudinal ridges (P < 0.001), subungual hyperkeratosis (P = 0.003), dystrophy (P = 0.017), discoloration (P = 0.052), and pitting (P < 0.001) correlated significantly with nail psoriasis. The presence of subungual hyperkeratosis, onycholysis, and longitudinal ridges significantly increased the odds of nail lichen planus. Only 6.79% of patients with longitudinal melanonychia had malignant melanoma, while most (26.54%) correlated with benign melanonychia.Conclusions: A detailed examination can narrow the differential diagnosis and avert unnecessary biopsies. However, in high-risk cases, physicians should regularly monitor the nails’ changes and response to treatment.
Maryam Nasimi; Robabeh Abedini; Zahra Halaji; Maryam Hosseinizadeh; Fariba Mohammadi
Abstract
Background: Basal cell carcinoma (BCC) is the most common form of malignancy in white populations. It has been hypothesized that dietary factors may play a role in BCC development. In this study, serum levels of folic acid and vitamin B12 were evaluated in patients with BCC to investigate the potential ...
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Background: Basal cell carcinoma (BCC) is the most common form of malignancy in white populations. It has been hypothesized that dietary factors may play a role in BCC development. In this study, serum levels of folic acid and vitamin B12 were evaluated in patients with BCC to investigate the potential role of these vitamins in BCC development.Methods: Forty-five BCC patients and 45 age- and sex-matched healthy controls were enrolled in the study. Patients with a history of radiotherapy in the affected area were excluded. All participants completed a questionnaire including demographic characteristics, and blood samples were taken to evaluate serum levels of folic acid and vitamin B12.Results: There were no significant differences in serum levels of vitamin B12 and folic acid between healthy controls and BCC patients. Serum levels of vitamin B12 were significantly higher in female patients than male patients.Conclusion: It seems that BCC is not related to serum levels of vitamin B12 and folic acid; however, this issue should be studied with larger sample sizes.
Maryam Nasimi; vahide Lajevardi; Hamidreza Mahmoudi; Fatemeh Arbab; Safoura Shakoei
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: ...
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Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: In this cross-sectional study, 66 patients with oral and follicular LP were evaluated for metabolic syndrome based on the US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria and were compared against 66 healthy controls. Waist circumference, body mass index (BMI), systolic and diastolic blood pressure, fasting blood sugar (FBS), and lipid profile were measured for each individual.Results: There was no significant difference in the prevalence of metabolic syndrome (13 [19.7%] vs. 8 [12.1%]; P = 0.23) and dyslipidemia (51 [77.3%] vs. 49 [74.2%]; P = 0.68) between the study groups. These findings remained statistically insignificant in both genders. The waist circumference (P = 0.008) and diastolic blood pressure (DBP) (P = 0.02) were significantly higher in the LP group than the healthy individuals. Our data showed that each unit increment in waist circumference and DBP leads to a 4.1% (P = 0.02) and 4.7% (P = 0.03) increase in the chance of LP,respectively.Conclusion: Patients with oral LP and LPP do not have a higher prevalence of metabolic syndrome or dyslipidemia than healthy individuals. However, they are more vulnerable to central obesity and high diastolic pressure, for which they should be routinely screened.
Robabe Abedini; Saeed Shakiba; Narges Ghandi; Farnaz Yazdaniamjad; Nazgol-Sadat Haddadi; Maryam Nasimi
Abstract
Background: Alopecia areata (AA) is an autoimmune disease involving the inflammation of hair follicles. In many autoimmune diseases, inadequate levels of vitamin D have been reported. We aimed to determine the association between vitamin D levels and AA.
Methods: In this case-control study, 50 AA patients ...
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Background: Alopecia areata (AA) is an autoimmune disease involving the inflammation of hair follicles. In many autoimmune diseases, inadequate levels of vitamin D have been reported. We aimed to determine the association between vitamin D levels and AA.
Methods: In this case-control study, 50 AA patients and 50 controls were assessed regarding serum levels of 25-hydroxy vitamin D [25-(OH)-D3]. The levels of 25-(OH)-D3 were classified as deficient ( < 20 ng/ml), insufficient (20 to 30 ng/ml), and sufficient ( > 30 ng/dl). The severity of the disease was scored according to the Severity of Alopecia Tool (SALT).
Results: The serum level of 25-(OH)-D3 was significantly lower in AA cases compared with the control group. Patients with the totalis or universalis pattern of hair loss had lower levels of 25-(OH)-D3 relative to patients with the patchy or ophiasis type of AA. Moreover, severe cases showed significantly lower levels of vitamin D relative to mild and moderate cases. We found a significant inverse association between 25-(OH)-D3 level and age. We found no association between serum levels of 25-(OH)-D3 and gender, disease duration, disease recurrence, nail involvement, or positive family history of AA.
Conclusion: AA patients had lower serum levels of vitamin D, though this did not contribute to the severity or duration of disease or pattern of hair loss. More studies are required to evaluate the role of vitamin D supplementation in the pathophysiology of AA.
Arghavan Azizpour; Zeinab Aryanian; Azita Nikoo; Maryam Nasimi; Azadeh Goodarzi; Ifa Etesami
Abstract
Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is known as an uncommon disorder of keratinization in which acrosyringium is involved; however, its causes have yet remained unknown. It is presented clinically by discrete keratotic papules on distal extremities arranged ...
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Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is known as an uncommon disorder of keratinization in which acrosyringium is involved; however, its causes have yet remained unknown. It is presented clinically by discrete keratotic papules on distal extremities arranged in a linear pattern along Blaschko lines. Histopathologically, it is characterized by cornoid lamella, which is almost always located overlying an acrosyringium. We present a case with an unusual presentation of extensive PEODDN lesions along the lower extremity. Our case was a young woman presented with multiple keratotic elevated papules on her left sole since her birth. In continuity with the lesions on her sole, a linear plaque was extended up to her buttock. Histopathology showed hyperkeratosis with cornoid lamella overlying the acrosyringium. The rarity of PEODDN and interesting presentation of the lesions on the sole of our patient with extension in a linear Blaschko pattern up to her buttock resembling verrucous linear epidermal nevus encouraged us to present this case.
Robabeh Abedini; Vahideh Lajevardi; Maryam Nasimi; Zahra Hallaji; Mahtab Darvish
Abstract
Background: The role of smoking and alcohol consumption in the pathogenesis of psoriasis is well-known; however, certain published studies have focused on the relationship between substance abuse and psoriasis. The present study was conducted to evaluate the prevalence of tobacco ...
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Background: The role of smoking and alcohol consumption in the pathogenesis of psoriasis is well-known; however, certain published studies have focused on the relationship between substance abuse and psoriasis. The present study was conducted to evaluate the prevalence of tobacco smoking, and substance and alcohol use in patients with psoriasis.Methods: Patients with a definite diagnosis of psoriasis at ages of 15 or more were recruited and general information of patients and their smoking behavior, alcohol consumption and substanceabuse were further collected.Results: 203 patients (103 men and 100 women) with psoriasis were included in this cross-sectional study. There were 76 smokers (37.45%) and 49 patients (24.1%) who consumed alcohol. Smoking, opium and alcohol consumption were significantly higher in men with psoriasis compared with women (P-values = 0.0001, 0.003, 0.002, respectively). Tranquilizer use was higher in married patients (P = 0.002), and those with joint involvements (P = 0.009). Hookah use was considerably high in female psoriatic patients, although not statistically significant (P = 0.37). Moreover, patients older than 40 years, and with nail disease (odds Ratio = 3.8) weremore prone to hookah use.
Conclusion: Our study revealed that the prevalence of smoking, opium and alcohol consumption is higher in men with psoriasis. Moreover, tranquilizer use is higher in married patients, and those with joint involvements. These findings should prompt public health workers to consider the modifiable habitual risk factors in patients with psoriasis.