M Shahidi Dadras; H Naseh Ghafoori; L Gachkar
Volume 6, Issue 4 , 2003, , Pages 3-10
Abstract
Background: The current treatments of recurrent aphthous stomatitis are not very effective and are not justified for long term using due to their potential side effects. Objective: To compare the efficacy of topical sucralfate mouthwash with topical tetracycline mouthwash in recurrent aphthous stomatitis. ...
Read More
Background: The current treatments of recurrent aphthous stomatitis are not very effective and are not justified for long term using due to their potential side effects. Objective: To compare the efficacy of topical sucralfate mouthwash with topical tetracycline mouthwash in recurrent aphthous stomatitis. Patients and Methods: In a randomized matched clinical trial, 60 patients with recurrent aphthous stomatitis fulfilling our inclusion criteria, referred to skin clinics affiliated to Skin Research Center in Shahid Beheshti University of Medical Sciences in 1380-81 were assessed. The patients were randomly divided in two groups, matched for age and type of the ulcer. The case group (26 patients) used a mouthwash containing 1gr sucralfate per 15cc, and the control group (34 patients) used a mouthwash containing 250mg tetracycline per 15cc, four times a day and were assessed every 2 weeks. The data were analyzed by chi-square and t-tests (P<0.05). Results: There were no significant difference between two groups regarding the frequency, healing time and pain of the aphthous lesions. Patients were more satisfied with the sucralfate suspension than tetracycline suspension in the end of treatment period (P<0.03) and in the end of follow up period (P<0.04). No side effects were seen in two group. Conclusion: Sucralfate suspension mouthwash can be considered equally effective as tetracycline mouthwash in treating recurrent aphthous stomatitis. It can be considered as a special modality for aphthous ulcer treatment due to lack of systemic toxicity and side effects even if accidentally swallowed or absorbed through mucosal surfaces.
L Dastgheib; A Alborzi; F Djokar; B Abudi; M Kalani
Volume 6, Issue 1 , 2002, , Pages 5-9
Abstract
Background: Acne vulgaris is a self-limited disease that mainly involves the sebaceous follicles. Systemic antibiotic is a common therapeutic modality, so bacterial resistance can be a problem. Objectives: Assessment of Propionibacterium resistance to erythromycin, tetracycline, clindamycin and spiramycin. ...
Read More
Background: Acne vulgaris is a self-limited disease that mainly involves the sebaceous follicles. Systemic antibiotic is a common therapeutic modality, so bacterial resistance can be a problem. Objectives: Assessment of Propionibacterium resistance to erythromycin, tetracycline, clindamycin and spiramycin. Patients and Methods: Sampling was done on lesions of 123 patients with acne vulgaris who referred to dermatology clinic of Shahid Dr. Faghihi hospital in Shiraz. After isolation and confirmation of P.acne minimal inhibitory concentration (MIC) of above-mentioned antibiotics were measured with agar dilution test. Results: From 123 patients, 129 samples were taken. Presence of P.acnes was confirmed in 62 samples. MICs for antibiotics were: Tetracycline 0.03-0.125 µg/ml, erythromycin 0.015-0.06 µg/ml, clindamycin 0.03-0.5 µg/ml and spiramycin 0.015-0.25 µg/ml. Conclusion: The samples of P.acnes isolated from acne vulgaris lesions in this study were sensitive to above mentioned antibiotics.