Roudsari Mohammad Rahmati; Malekzad Farhad; Sabeti Shahram; Ershadi Sarah; Yousefi Forough; Tonkaboni Mihan Pourabdollah
Volume 18, Issue 3 , 2015, , Pages 108-115
Abstract
Background: Scarring (cicatricial) alopecia represents a complex group of inflammatory disorders, mainly characterized by destruction of the hair follicle unit. Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are the two main causes of primary cicatricial alopecia (PCA), both leading ...
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Background: Scarring (cicatricial) alopecia represents a complex group of inflammatory disorders, mainly characterized by destruction of the hair follicle unit. Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are the two main causes of primary cicatricial alopecia (PCA), both leading to hair follicle destruction and irreversible alopecia. However, they are different in pathogenesis and sometimes are diagnostically challenging.Methods: Twenty-eight formalin-fixed paraffin-embedded (FFPE) specimens of skin biopsies from 17 patients with a clinicopathologic diagnosis of LPP and 11 patients diagnosed as DLE were included. Histopathological study was performed with Haematoxylin and Eosin (H&E)-stained slides; then, immunohistochemical staining (IHC) was performed against CD20, CD3, CD4, and CD8 to evaluate and compare the type and distribution pattern of dermal inflammatory infiltrate.Results: Immunohistochemical findings showed a predominance of T-cells in both groups. CD8+ T-cells were significantly more abundant in LPP (15 cases with 10-50% of infiltration) than DLE (11 cases with
Sh Babaei Nejad; E Khodaeiani; M Amir Nia
Volume 8, Issue 6 , 2006, , Pages 496-500
Abstract
Background and aim: Cicatrical alopecia refers to lesions associated with permanent destruction of hair follicles. Several diseases such as folliculitis decalvans, lichenplanopilaris (LPP) and discoid lupus erythematosus (DLE) may result in cicatricial alopecia. Since cicatricial alopecia is scarring ...
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Background and aim: Cicatrical alopecia refers to lesions associated with permanent destruction of hair follicles. Several diseases such as folliculitis decalvans, lichenplanopilaris (LPP) and discoid lupus erythematosus (DLE) may result in cicatricial alopecia. Since cicatricial alopecia is scarring and affects both the appearance and psychosocial behaviours of the patients and also it can be an alarming sign of some systemic diseases, making an early diagnosis and proper treatment can prevent progression and further complications. The aim of this study was to determine the epidemiologic and clinicopathologic characteristics of cicatricial alopeica.Materials and Methods: A total of 100 patients with cicatricial alopecia were selected from those referred to the skin clinic of Sina hospital in Tabriz for further assessment from 1997 to 2004. Their disease was pathologically proven. All epidermiologic and clinicopathologic data were obtained through questionaires. The results were analysed by means of descriptive statistical methods.Results: Fifty-two of hundred patients were male and 48 were female. The highest incidence rate was found in 3rd, 4th and 5th decades of life. The underlying diseases in descending order were: 30% (24 male, 6 female) had folliculitis decalvans, 25% (10 male and 15 female) had DLE, 18 ( 6 male, 12 female) pseudopelade of Brocq, 14% (4 male and 10 female) had LPP, 8% (4 male, 4 female) had morphea and 5 (4 male , 1 female) had keloidalis folliculitis. From a histo-pathologic point of view, lymphocytic cicatricial alopecia was more common among middle aged women (65%) whereas the neutrophilic type was more prevalent among middle aged men (35%). The ratio of lymphocytic to neutrophilic cicatricial alopecias was 2/1.Conclusion: Considering the high incidence of cicatricial alopecia, early stage diagnosis by biopsy and proper treatment will reduce further progression and especially alleviate psychosocial disturbances.
M Barzegari; SN Emadi; RM Robati
Volume 8, Issue 3 , 2005, , Pages 237-241
Abstract
Congenital diffuse Melanosis is one of the rarest clinical manifestations of hereditary universal Melanosis and only few cases have been reported all over the world. The presented case is a 54-year-old man who presented to us complaining of erythematous annular lesions on his face and neck since 8 months ...
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Congenital diffuse Melanosis is one of the rarest clinical manifestations of hereditary universal Melanosis and only few cases have been reported all over the world. The presented case is a 54-year-old man who presented to us complaining of erythematous annular lesions on his face and neck since 8 months ago. Diffuse pigmentation of his skin took our attention. According to the patient, diffuse hyperpigmentation was present at birth and there was no obvious changes up to now. His mother and sister had similar hyperpigmentation. He had 2 sons with a similar hyperpigmentation, but his daughter had normal skin pigmentation. All laboratory investigation for the causes of hyperpigmentation were reported normal and investigation for causes of secondary hyperpigmentation did not reveal any abnormality. In histopathological assay, the erythematous lesion was reported to be discoid lupus erythematous and the diagnosis of hyperpigmented lesion reported as congenital diffuse Melanosis.
MJ Nazemi; S Sotoodeh; H Moslehi
Volume 6, Issue 2 , 2003, , Pages 5-13
Abstract
Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The ...
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Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The clinical, Paraclinical and pathological findings in 50 biopsy proven patients with DLE referred to Razi Hospital in Tehran in 1377 were recorded in special questionnaires. Data were analyzed by SPSS software, T-Student and chi-square tests were used. Results: The number of female patients was twice of males, majority in the age range of 20 to 50 years, Most of the patients had no complaints except for skin eruptions. Paraclinical abnormalities were rare. The paraclinical changes were various, but hydropic degeneration of basal layer was found in all cases. Conclusion: Complementary studies are suggested to evaluate similarities and differences in Iranian and non-Iranian patients with DLE.
AM Namian; M Rahimi Nejad
Volume 4, Issue 3 , 2001, , Pages 3-10
Abstract
Background: Discoid Lupus Erythematosus (DLE) is chronic, recurrent and relatively benign skin disorder. Objective: The purpose of this study was to investigate the laboratory tests (ANA, LE-Cell, ESR, CRP, RF, VDRL, WBC, PLT) in patients with DLE. Patients and Methods: In this study, laboratory tests ...
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Background: Discoid Lupus Erythematosus (DLE) is chronic, recurrent and relatively benign skin disorder. Objective: The purpose of this study was to investigate the laboratory tests (ANA, LE-Cell, ESR, CRP, RF, VDRL, WBC, PLT) in patients with DLE. Patients and Methods: In this study, laboratory tests of 51 patients with DLE who referred to the Dermatology clinic of Shahid Faghihi Hospital in Shiraz since Mehr 1377 to Shahrivar 1379, were investigated. Results: Positive ANA was found in 20% of patients (9.46) and 33% of patients (15.45) had ESR>20 mm/hr. Leukopenia, leukocytosis and thrombocytosis was found in 8% (4.51), 2% (1.51), and 2.5% of patients (1.40) respectively and none of the patients (From 45 patients) had thrombocytopenia. One patient from 40 patients (2.5%) showed positive RF test. LE-cell preparation, CRP and VDRL tests were done in 40, 41 and 42 patients respectively and were negative in all of them. Conclusion: Some of the patients with DLE show abnormalities in laboratory tests. ANA positively and high ESR are more common than others.