Hossein Mortazavi; Arileza Mortazavi; Anahita Rostami; Mohammadraza Javadi; Robabeh Abedini; Amir Teimourpour; Kheirolah Gholami; Ali Khamesipour
Abstract
Background: Little data on severe cutaneous adverse drug reactions (SCADRs) is available, especially in Iran. Therefore, there is a need for more studies in this field. We aimed to evaluate the clinical pictures and laboratory data of patients with SCADR in a tertiary dermatology center in Tehran, Iran.Methods: ...
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Background: Little data on severe cutaneous adverse drug reactions (SCADRs) is available, especially in Iran. Therefore, there is a need for more studies in this field. We aimed to evaluate the clinical pictures and laboratory data of patients with SCADR in a tertiary dermatology center in Tehran, Iran.Methods: In this retrospective study, patients with a clinical diagnosis of SCADR based on the World Health Organisation’s definition and histopathologic findings were included. Causality and preventability measures were assessed based on previous criteria, including the Naranjo score and the Schomock and Thronton scale.Results: Thirty-nine patients with a mean age of 43 ± 17 years participated in the study. SCADRs were more common in females than in males (2.9/1). SCADRs included Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), acute generalized exanthematous pustulosis (AGEP), and drug reactions with eosinophilia and systemic symptoms (DRESS). Thirty-one patients presented a Naranjo score of 5-8, indicating probable drug reactions. The remaining eight patients (with scores of 1-4) were determined as having possible drug eruptions. Regarding the category of culprit drugs, anticonvulsants (49%), antimalarials (15%), antibiotics (13%), and antihypertensives (10%) were themost frequent causes of SCADR, with lamotrigine being the single most common agent.Conclusion: The most frequent clinical presentation of SCADR was SJS/TEN, followed by AGEP and DRESS. The most frequent cause of SCADR was anticonvulsant drugs.
Jamalpour Mahdi; Saki Nasrin; Nozari Farnoosh
Abstract
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology. There is evidence that bacteria may contribute to initiating the inflammatory response in HS patients. To date, data on bacteria found in HS lesions and their resistance rates are rare. Methods: The ...
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Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology. There is evidence that bacteria may contribute to initiating the inflammatory response in HS patients. To date, data on bacteria found in HS lesions and their resistance rates are rare. Methods: The results of bacterial cultures and antibiotic susceptibility of the isolated bacteria obtained from HS lesions of 26 patients at our dermatology department were analyzed. Results: A total of 50 samples were collected from HS patients. Of the 50 lesional samples, 46 were culture-positive. The 50 lesional samples yielded 61 isolates. The most common isolated bacteria were Staphylococcus aureus, Diphtheroid, and Escherichia coli. Most of the isolates were resistant to penicillin G, followed by erythromycin, clindamycin and ampicillin. The lowest resistant rates were observed for ceftriaxone, imipenem, amikacin, tetracycline, and vancomycin. Conclusions: Due to the low susceptibility rate and antiinflammatory properties, tetracycline may represent as an effective antibiotic agent for therapy in HS patients.
Alizadeh Narges; Oskuee Alireza Ba–Eeman; Golchai Javad; Sadre-Eshkevari Shahryar; Darjani Abbas; Kazemnejad Ehsan; Eftekhari Hojat; Mohtasham-Amiri Zahra
Volume 17, Issue 2 , 2014, , Pages 54-58
Abstract
Background: Methicillin–resistant Staphylococcus aureus (MRSA)has recently emerged as a worldwide major nosocomial pathogenthat causes significant morbidity and mortality. MRSA is frequentlycolonized on the skin. The aim of this study was to determinethe MRSA colonization/infection prevalence and ...
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Background: Methicillin–resistant Staphylococcus aureus (MRSA)has recently emerged as a worldwide major nosocomial pathogenthat causes significant morbidity and mortality. MRSA is frequentlycolonized on the skin. The aim of this study was to determinethe MRSA colonization/infection prevalence and to evaluatethe potential risk factors for its development in the hospitalizedpatients in a referral dermatology ward.Method: In this cross sectional study, 203 patients with cutaneouslesions who were admitted to the dermatology ward of a tertiaryteaching hospital from 2008 to 2010 were recruited. Sampleswere collected during the first 48 hours of admission. S. aureuswas identified using gram staining, catalase, and coagulase tests.The disk diffusion method was used for testing the sensitivityof different bacteria to antibiotics. Mueller-Hinton agar was theculture medium used for MRSA susceptibility testing.Result: Staphylococcus. aureus was the most common pathogenthat grew in 56.2% (114/203) of isolates. MRSA was foundin 35.5% (82/203) of isolates. The duration of the cutaneouslesions, age group, positive history of antibiotic use in past 12months, and underlying diseases were statistically differentbetween the patients with colonization of MRSA and methicillinsensitiveStaphylococcus aureus (MSSA) (P
Ehsani Amir Houshang; Hosseini Mahboobeh-Sadat; Lajvardi Vahideh-Sadat
Volume 10, Issue 2 , 2007, , Pages 142-156
Abstract
Erythromycin was the first macolide discovered in 1952. In 1990s new macrolides including clarithromycin, azithromycin, and dirithromycin were introduced to the market. We provide a review of their structure, pharmacokinetics, mechanisms of action, and indications in dermatology.
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Erythromycin was the first macolide discovered in 1952. In 1990s new macrolides including clarithromycin, azithromycin, and dirithromycin were introduced to the market. We provide a review of their structure, pharmacokinetics, mechanisms of action, and indications in dermatology.