Kambiz Kamyab Hesari; AliReza Ghanadan; Vahidehsadat Azhari; Shirin Taraz Jamshidi; Reza Amiri; Hamidreza Mahmoudi; Ali Salehi Farid; Ali Nili; Anahita Borzouei; Maryam Daneshpazhooh
Abstract
Background: Lichen planopilaris (LPP) is the most common form of immune-mediated scarring alopecia. We evaluated the histopathologic features of LPP in vertical sections of scalp biopsies and compared findings between the scarring and nonscarring phases of the disease.Methods: From June 2019 to June ...
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Background: Lichen planopilaris (LPP) is the most common form of immune-mediated scarring alopecia. We evaluated the histopathologic features of LPP in vertical sections of scalp biopsies and compared findings between the scarring and nonscarring phases of the disease.Methods: From June 2019 to June 2020, vertically sectioned scalp biopsies of 70 new cases of LPP were examined (H&E) according to North American Hair Research Society criteria. Furthermore, patients were divided into two groups based on either the presence or the absence of vertical fibrous bands, and other histopathological features were compared between these two groups.Results: Characteristic findings of LPP were perifollicular lymphocytic infiltration (97.1%), follicular interface degeneration (60%), and perifollicular plasmacytic infiltration (21.4%). Vacuolar degeneration in the dermo-epidermal junction (38.6%), perifollicular lamellar fibroplasia (67.1%), loss of sebaceous glands (87.1%), perifollicular cleft formation (28.6%), and vertical fibrous tracts (65.7%) were also found. Furthermore, we found a significant correlation between the presence of fibrous tracts with both loss of sebaceous glands (P = 0.005) and the presence of lamellar fibroplasia (P = 0.015).Conclusion: The most common findings in the histopathological examination of LPP slides are perifollicular lymphocytic infiltration and loss of the sebaceous glands. Furthermore, sebaceous gland loss and perifollicular lamellar fibroplasia correlate with the scarring phase of LPP.
Dastgheib Ladan; Saki Nasrin; Heiran Alireza; Kardeh Bahareh; Saki Mohammad Reza
Volume 20, Issue 3 , 2017, , Pages 79-83
Abstract
Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. ...
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Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. The aimof this study is to assess the prevalence of certain autoimmune diseases in first degree relatives of patients with psoriasis compared with a control group. Methods: In this cross-sectional study we used a questionnaire to compare the frequency of type 1 diabetes, autoimmune thyroid disease, vitiligo, lupus erythematosus, multiple sclerosis, ulcerative colitis, Crohn’s disease, and rheumatoid arthritis in first degree relatives of 109 pathologically confirmed psoriasiscases with the first degree relatives of 109 age-sex matched controls. R programming language (version 3.3.1 for Windows) and the rattle graphical user interface (GUI) package were applied for statistical analysis. A P-value?0.05 was considered to be statistically significant. Results: We compared 955 first degree relatives of psoriatic patients with 934 family members of the controls. There was significantly greater total autoimmune diseases [odds ratio (OR): 2.74, 95% confidence interval (CI): 1.95-3.87, P<0.001), particularly psoriasis (OR: 38.66, 95% CI: 5.3-282.19, P<.0001), in first degree relatives of psoriatic patients compared to family members of the control group. Regardless of gender, autoimmune thyroid disease was more prevalent among first degree relatives of psoriatic patients (OR: 2.81, 95% CI: 1.36-5.83, P=.0066). No statistically significant difference was found regarding type 1 diabetes, rheumatoid arthritis, multiple sclerosis, vitiligo, Crohn’s disease, and ulcerative colitis. Conclusion: First degree relatives of patients with psoriasis had significantly higher autoimmune diseases. This finding was particularly noticed for psoriasis and autoimmune thyroid disease.
M Barzegari; Sh Shams Davachi; A Kianfar
Volume 7, Issue 4 , 2004, , Pages 261-263
Abstract
Background: Prolactin, a neurohormone, can act as a stimulator of immunity in a number of autoimmune diseases and its high levels have been shown in these diseases. Objective: This study was designed to discover the possible role of prolactin in autoimmune blistering skin diseases. The main goal was ...
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Background: Prolactin, a neurohormone, can act as a stimulator of immunity in a number of autoimmune diseases and its high levels have been shown in these diseases. Objective: This study was designed to discover the possible role of prolactin in autoimmune blistering skin diseases. The main goal was to compare the serum prolactin levels and the frequency of hyperprolactinemia in autoimmune skin patients with a control group. Patients and Methods: Serum prolactin levels were measured in 44 patients with autoimmune blistering skin diseases and 44 age and sex matched normal persons. Results: The mean serum prolactin level was higher in the patients group than the control group (13.7 ng/ml vs. 8.4 ng/ml). Seven of 44 patients (16%) had hyperprolactinemia, which was significantly higher than control group (P=0.006). Conclusion: According to this study a higher frequency of hyperprolactinemia was observed in patients suffering from autoimmune blistering diseases in comparison with a control group.