Hassan Seirafi; Mohamma-Javad Nazemi; Saeed Amini; Hossein Shabanzadeh-Dehkordi; Pedram Mehrian
Volume 9, suppl.1 , 2006, , Pages 4-4
Abstract
Pyoderma gangrenosum is a rare non infectious neutrophilic dermatosis commonly associated with underlying systemic disease. Many treatment regimens have been reported. Herein, we report a case of refractory pyoderma gangrenosum with good response to combination of cyclosporine and mycophenolate mofetil.
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Pyoderma gangrenosum is a rare non infectious neutrophilic dermatosis commonly associated with underlying systemic disease. Many treatment regimens have been reported. Herein, we report a case of refractory pyoderma gangrenosum with good response to combination of cyclosporine and mycophenolate mofetil.
Akram Ansar; Banafsheh Hashemi
Volume 10, Suppl.2 , 2007, , Pages 4-4
Abstract
Becker's nevus is a unilateral hyperpigmented area of skin with geographical borders. It is usually located on shoulders, anterior chest, scapular region and upper arms. Sometimes it shows evidence of androgen hypersensitivity and co-localizing with other developmental anomalies. We report a 12-year-old ...
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Becker's nevus is a unilateral hyperpigmented area of skin with geographical borders. It is usually located on shoulders, anterior chest, scapular region and upper arms. Sometimes it shows evidence of androgen hypersensitivity and co-localizing with other developmental anomalies. We report a 12-year-old girl with clinical and histopathological findings compatible with Becker's nevus on her left chest accompanied with ipsilateral breast hypoplasia.
Sepideh Tehrani; Setareh Tehrani; Mitra Esmaili-Azad; Mahnaz Vaezi; Nazi Saljoughi
Volume 15, Issue 1 , 2012, , Pages 11-14
Abstract
Background: Melasma is a brown or grayish brown symmetrical facial hyperpigmentation.A number of medicamens can be used for the treatment of this condition. For better results in treating melasma, combination therapy is preferred. The aim of this study was to determine the clinical efficacy and adverse ...
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Background: Melasma is a brown or grayish brown symmetrical facial hyperpigmentation.A number of medicamens can be used for the treatment of this condition. For better results in treating melasma, combination therapy is preferred. The aim of this study was to determine the clinical efficacy and adverse effects of azelaic acid 20% plus hydroquinone 5% versus hydroquinone 5% alone in the management of melasma. Method: This study was performed as a double blind randomized clinical trial. We randomly prescribed two regimes including azelaic acid 20% cream plus hydroquinone 5% or hydroquinone 5% alone once daily for 4 months in 64 patients. Clinical efficacy (with MASI score) and side effects were assessed after one, two and four months of treatment. Result: MASI score reduction was from 9.35 to 2.9 in patients using azelaic acid 20% plus hydroquinone and from 9.58 to 4.02 in patients using hydroquinone 5%. Drug adverse effects, including burning (most frequent), itching, stinging, dryness and erythema, were present in 50% of the participants in the azelaic acid 20% plus hydroquinone group and 35% of the individuals in the hydroquinone 5% group (P= 0.034), but were tolerated by most patients. Conclusion: Both therapeutic regimens showed a remarkable efficacy in the treatment of melasma but azelaic acid 20% plus hydroquinone was more effective with a more rapid onset of therapeutic response. Azelaic acid 20% plus hydroquinone had more side effects although they were slight in most cases.
Mirnezami Mina; Rahimi Hoda
Volume 13, Issue 1 , 2010, , Pages 12-15
Abstract
Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. ...
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Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. The aim of this study was to identify factors associated with pruritus in these patients. Methods: This cross sectional study was done on 100 patients who were under hemodialysis because of end stage renal disease. In patients who were suffering from uremic pruritus, the severity of pruritus was assessed and the relationship between the presence and severity of pruritus with serum levels of hemoglobin, creatinine, urea, phosphate, calcium, albumin, parathormone hormone (PTH) and alkaline phosphatase was evaluated.Results: One hundred patients (48 women and 52 men) entered this study. Pruritus was found in 45% of the patients. We found a significant relationship between severity of pruritus with age and serum level of phosphate. No significant correlation was found between the severity of pruritus and sex, duration of dialysis, underlying renal disease and serum levels of hemoglobolin, urea, albumin, PTH, alkaline phosphatase, calcium, and creatinine. Conclusions: Pruritus is still a common problem in hemodialysis – dependent patients. Higher serum levels of phosphate seems to be an important factor associated with uremic pruritus.
Ayatolahi Seyed Amin Mossavi-; Farajzadeh Saeedeh; Fekri Ali Reza; Vares Behrooz; Fekri Sahba
Volume 12, Suppl.3 , 2009, , Pages 12-15
Abstract
We describe a 31-year-old man, a known case of hepatitis C infection for 11 years, who presented with a chronic non-healing large deep ulcer on the dorsum of the right foot for five months. Fusarium solani infection was confirmed by skin biopsy and culture. The biopsy specimen showed an unusually extensive ...
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We describe a 31-year-old man, a known case of hepatitis C infection for 11 years, who presented with a chronic non-healing large deep ulcer on the dorsum of the right foot for five months. Fusarium solani infection was confirmed by skin biopsy and culture. The biopsy specimen showed an unusually extensive dermal invasion with fungal hyphae. The patient's response to oral itraconazole 100 mg/day for 3 months was excellent. Closed monitoring of liver enzymes was done before and during the treatment course.
Mohammad Dehghan; Sepideh Hajian; Nazila Alborzi; Afsaneh Borgheyee; Amir Hussein Noohi
Volume 12, Issue 1 , 2009, , Pages 13-15
Abstract
Background: Dermatophytes are a group of closely related fungi that invade keratinized tissues (skin, hair and nails) of humans and animals and produce infections called dermatophytosis. Our objective was to determine causative agents of dermatophytosis in Gorgan, North of Iran. Methods: Data was based ...
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Background: Dermatophytes are a group of closely related fungi that invade keratinized tissues (skin, hair and nails) of humans and animals and produce infections called dermatophytosis. Our objective was to determine causative agents of dermatophytosis in Gorgan, North of Iran. Methods: Data was based on collecting specimens from 1108 patients clinically suspected to have fungal infection during five years from 2003 through 2007. Specimens were collected from hair, nail and skin and were investigated by direct examination and cultured in Sabouraud dextrose agar. Fungal colonies were identified by macroscopic and microscopic examination and supplementary tests. Results: 351 samples out of 1108 were positive for dermatophytes and 277 ones had positive cultures. Epidemophyton floccosum was the most frequent species (70.4%) followed by Trichophyton rubrum (14.5%) and Microsporum audouinii (7.2%). Regarding the location of the lesions, groin and nails were the most frequent sites that developed dermatophytosis in the majority of the patients. Conclusion: Dermatophytosis is probably still one of the most infectious diseases in Iran. The anthropophilic (E.fluoccosum) and zoophilic (T. rubrum) species were the most common causes of dermatophyte of tinea in Gorgan, north of Iran. The frequency of tinea was higher in females and tinea cruris showed a remarkably increasing rate and can be an important public health issue in Gorgan.
Emad Maryam; Moezzi Jafar; Dastgheib Ladan
Volume 16, Issue 1 , 2013, , Pages 13-5
Abstract
Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been ...
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Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been thestandard treatment.Method: The study was an open clinical trial with a split-facedesign. All patients applied hydroquinone 4% cream on theright side and azelaic acid 20% cream on the left side for 20weeks. Modified melasma area and severity index (mMASI) wasdetermined for each patient at the beginning and at the end ofstudy and compared statistically.Result: Thirty-three patients were included in the study. Althoughboth medications were effective in reducing mMASI, there wasno statistical difference between the two (P value=0.6). Overall,69.7% of the patients on the hydroquinone 4% side and 63.6%on the azelaic acid 20% side showed good to excellent response.The subjective patient assessment of improvement was 75.7% forhydroquinone 4% and 66.6% for azelaic acid 20%.Conclusion: Both topical hydroquinone 4% and topical azelaicacid 20% had almost similar effects. Considering the relativelyless known side effects of azelaic acid compared to hydroquinone,it can be an appropriate substitute in the treatment of melasma.
Afsaneh Sadeghzadeh-Bazargan; Elham Behrangi; Azadeh Goodarzi
Abstract
The coronavirus disease 2019 (COVID-19) is currently the most important global health problem. Due to its pandemic state and high mortality rate, it is critical to find useful interventions that reduce the mortality rate and boost patient survival. Since there is no specific antiviral treatment for the ...
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The coronavirus disease 2019 (COVID-19) is currently the most important global health problem. Due to its pandemic state and high mortality rate, it is critical to find useful interventions that reduce the mortality rate and boost patient survival. Since there is no specific antiviral treatment for the disease and given the growing amount of data about the role of the inflammatory response and cytokine storm in increased disease severity, we evaluated the mechanisms and possible positive effects of some specific anti-inflammatory drugs on the disease course of COVID-19 and examined some suggested treatments in the form of a scoping review article. It is important to select patients who may benefit from these treatments without inflicting any serious adverse effects. In our view, in approaching COVID-19 patients, we should consider the severity of the body’s inflammatory response. Mild cases may not require additional anti-inflammatory treatment or at least should be treated with safer immunoregulatory drugs such as chloroquines, whereas in severe cases with an overactive immune response evidenced by high serum inflammatory marker levels (TNF, ESR, CRP, WBC count, LDH, ferritin) and severe lung involvement in chest images, stronger immunoregulatory drugs (targeted immunotherapy) such as TNF and kinase inhibitors may be considered as adjunctive treatments in combination with antiviral drugs. However, further precisely designed studies are needed to confirm the therapeutic effect and safety of each of these anti-inflammatory drugs in COVID-19 patients and to determine their optimal dose, route of administration, and possible side effects.
SZ Famili; Gh Jafari
Volume 8, suppl , 2005, , Pages 14-17
Abstract
Dowling –Degos disease is a rare condition. It is inherited by an autosomal dominant gene. It usually presents in adult life as small, pigmented, asymptomatic macules in flexural regions. We report a 35-year-old woman with Dowling- Degos disease, in whom the reticular pigmentation confined to the ...
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Dowling –Degos disease is a rare condition. It is inherited by an autosomal dominant gene. It usually presents in adult life as small, pigmented, asymptomatic macules in flexural regions. We report a 35-year-old woman with Dowling- Degos disease, in whom the reticular pigmentation confined to the genital area.
Aghazadeh Nessa; Rahnama Nooshin; Nasrollahi Saman Ahmad; Komeili Ali; Firooz Alireza; Dowlati Yahya
Volume 20, Issue 1 , 2017, , Pages 15-20
Abstract
Background: Iran has achieved rapid scientific growth in the past two decades. Considerable growth in scientific publications by Iranian dermatologists matches the pace of Iran’s scientific publications in the previous decade. In this study, we aim to identify the current trends in Iranian dermatology ...
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Background: Iran has achieved rapid scientific growth in the past two decades. Considerable growth in scientific publications by Iranian dermatologists matches the pace of Iran’s scientific publications in the previous decade. In this study, we aim to identify the current trends in Iranian dermatology publications and authorship over the past decade. Methods: We compared papers indexed in the MEDLINE database at two time points, 2004 and 2014, using the PubMed Search engine. Results: We found 145 dermatology papers from Iran in 2014 compared to 31 papers in 2004, with an annual growth rate of 36.8%. There was a highly significant increase in the mean number of authors per article from 3.1 to 5.02 (P<0.001), with a significant decrease in the number of single-author papers. A significant decrease existed in the number of male first authors (83.9% to 63.4%; P=0.03). The number of papers published in specialized dermatology journals significantly decreased in 2014 from 80.6% to 42.1% (P<0.001), with 41.4% of the total papers published in Iranian journals. The mean impact factor (IF) per paper dropped from 2.01 to 1.75. Conclusion: The number of international publications by the Iranian dermatologist has proliferated during the past decade. Encouragement of international collaborations, production of high-quality and novel research, improvements to the standards and visibility of national journals, and higher adherence to authorship and publication ethics are essential perquisites for a more productive future for dermatology research in Iran.
Niloufar Torkamani; Eskandar Kamali Sarvestani; Mahsa Naseri
Volume 14, Issue 1 , 2011, , Pages 16-19
Abstract
Background: Pemphigus vulgaris, the most common form of pemphigus, is due to the production of auto-antibodies directed against adhesion molecules (desmoglein 1 and 3) that belong to the cadherin family. B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) may ...
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Background: Pemphigus vulgaris, the most common form of pemphigus, is due to the production of auto-antibodies directed against adhesion molecules (desmoglein 1 and 3) that belong to the cadherin family. B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) may play a significant role in autoimmune diseases such as pemphigus vulgaris. Only a few studies have been done on the level of APRIL and BAFF in PV patients but none have investigated both levels; therefore, determination of both proliferation inducing ligands (BAFF and APRIL) in pemphigus vulgaris is of significant importance and was considered as the goal of the present study. Methods: This analysis included 22 patients with PV and 22 sex and age matched healthy controls. None of the patients had previously been treated with corticosteroids or any immunosuppressive drugs in the previous three months. The BAFF and APRIL levels were evaluated in patient and control groups by use of ELISA method. Results: Comparison of the serum levels of BAFF and APRIL between patients and controls was done using Mann-Whitney U test. The BAFF levels in our 22 patients and control sera were undetectable. On the other hand, concentrations of APRIL in 22 cases were 2.09+/-4.94 and 0.85+/-2.01 in the control group. Conclusion: BAFF levels were undetectable in cases and the difference in APRIL levels between patient and control groups was not significant (p=0.28). So, it can be concluded that although BAFF and APRIL may play a role in autoimmune diseases, their role in pemphigus vulgaris is doubtable.
Dadras Mohammad Shahidi; Golfeshan Atefeh; Younespour Shima
Volume 18, Issue 1 , 2015, , Pages 16-19
Abstract
Background: The ABO blood group antigens play a role in thepathophysiology of some diseases and several researches haveinvestigated this relationship in the field of dermatology. In thepresent study, an attempt was made to find the distribution ofblood types in patients with pemphigus vulgaris and chronicplaque ...
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Background: The ABO blood group antigens play a role in thepathophysiology of some diseases and several researches haveinvestigated this relationship in the field of dermatology. In thepresent study, an attempt was made to find the distribution ofblood types in patients with pemphigus vulgaris and chronicplaque type psoriasis.Method: Fifty patients with chronic plaque type psoriasis, 50patients with pemphigus vulgaris and 100 healthy persons ascontrol group, were selected as the study population. ABO bloodgrouping was determined by the cell type tube test method, usingstandard commercial anti/A, anti/B and 5% suspension of redblood cells. Chi square test was used to compare the frequencyof ABO blood groups in patients and control groups.Result: Among the 50 patients with psoriasis, 21 (42%) hadblood group O, 15 (30%) blood group A, 10 (20%) blood groupB and 8 (4%) had blood group AB. Among the 50 patients in thepemphigus group, 22 (44%) had blood group O, 19 (38%) bloodgroup A, 8 (16%) blood group B and 1 (2%) had blood groupAB. The distribution of blood groups in patients with these twodiseases was not significantly different from the control group.Conclusion: Despite some researches, which found associationsbetween blood group antigens and psoriasis or pemphigus, thisstudy did not find any such relationship.
Rouhullah Dehghani; Afsaneh Hashemi; Seyed Mahdi Takhtfiroozeh; Elahe Chimehi; Elham Chimehi
Volume 19, Issue 1 , 2016, , Pages 16-20
Abstract
Background: Cimex lectularius (bed bug) are insects abundantly found in hot, temperate areas. This study is related to the outbreak of Cimex lectularius in a construction site around Polour in Amol, Iran. This cross-sectional study has examined 182 prefabricated houses made of intermodal containers [Conex] ...
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Background: Cimex lectularius (bed bug) are insects abundantly found in hot, temperate areas. This study is related to the outbreak of Cimex lectularius in a construction site around Polour in Amol, Iran. This cross-sectional study has examined 182 prefabricated houses made of intermodal containers [Conex] converted to a temporary housing, in a construction site.Methods: The studied population comprised 1434 men. We used a questionnaire to gather information. The bugs were collected from the floor of the room, beds, bed sheets, blankets, pillows, and mattresses in each surface meter over a fixed time with the help of forceps and a flashlight.Results: From the 182 examined containers, 164 (approximately 90.1%) had evidence of contamination by bed bugs. From the examined people, 1243 (86.7%) had bug bites. Males between the ages of 35 to 44 (41.0 %) years had the most bites. The hands (38.3%) and abdominal area (23.7%) were the locations with the most bites.Conclusion: The study has shown that the bugs entered the site on second hand objects such as wooden beds. Consulting health experts and training people in areas that are suspicious for these bugs can decrease the problems caused by the bites.
Rad Mahnaz Mahmoudi; Mohammadi Akram Mir Amin; Barton Richard C
Volume 11, Issue 1 , 2008, , Pages 17-20
Abstract
Background: Trichophyton rubrum (T. rubrum) is the most common cause of dermatophytosis of skin and nail tissue. Strain identification in Trichophyton rubrum is important for identification of strain-related differences in infectivity potential or transmissibility and epidemiological studies. PCR typing ...
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Background: Trichophyton rubrum (T. rubrum) is the most common cause of dermatophytosis of skin and nail tissue. Strain identification in Trichophyton rubrum is important for identification of strain-related differences in infectivity potential or transmissibility and epidemiological studies. PCR typing could determine whether the original isolate is responsible for re-infection or a new strain has been acquired.Methods: A minipreparation method for DNA from dermatophytes was used. Tandemly repetitive subelements (TRS-1 & TRS-2) of NTS region at ribosomal DNA of 23 T.rubrum isolates were amplified and the PCR products were separated by electrophoresis in 2% agarose gel (200 mA, 140 V), visualized by staining with ethidium bromide, and photographed.Results: On the basis of copy number of TRS-1 and TRS-2, 8 out of our 23 samples were type 2 & II, respectively. Six of them were type 3 & II, four isolates were type 1 & II, two isolates were type 4 & II, two isolates were type 1 & I and one isolate was type 5 & II.Conclusion: In this study, most of T. rubrum isolates were type 2 & II, dissimilar to European studies where type 1 & II has been the most common. The present study showed that 26.1% of Iranian isolates were type 1 in contrast with a previous study which has demonstrated a much lower prevalence in Asians (5%).
S Family
Volume 4, Issue 2 , 2001, , Pages 17-20
Abstract
Background: Vitiligo is a pigmentary disorder of the skin, which has been reported in association with thyroid disorders. Objective: The aim of this study was to assess thyroid disorders in vitiligo patients. Patients and Methods: In this case-control study, thyroid function tests were evaluated in seventy ...
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Background: Vitiligo is a pigmentary disorder of the skin, which has been reported in association with thyroid disorders. Objective: The aim of this study was to assess thyroid disorders in vitiligo patients. Patients and Methods: In this case-control study, thyroid function tests were evaluated in seventy patients with vitiligo and compared with a control group. Results: Nine of seventy patients with vitiligo (12.9%) and one of controls (1.4%) had abnormal thyroid function tests. Conclusion: Thyroid disorders are more common in vitiligo.
A Asilian; S Karbasioun
Volume 8, suppl , 2004, , Pages 17-20
Abstract
Herein we report a 6-year-old Afghans patient referred to Department of Dermatology, St. AL-Zahra Hospital in Isfahan with ulcerative and nodular lesions disseminated over the face, arms, buttocks, pelvic girdle and legs in 2002. Direct smears of the lesions were positive for Leishman bodies. Leishmanin ...
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Herein we report a 6-year-old Afghans patient referred to Department of Dermatology, St. AL-Zahra Hospital in Isfahan with ulcerative and nodular lesions disseminated over the face, arms, buttocks, pelvic girdle and legs in 2002. Direct smears of the lesions were positive for Leishman bodies. Leishmanin skin test was negative. He also had dactylitis in some digits and toes. PCR from bone biopsy showed Mycobacterium tuberculosis. So he was treated according to diagnosis of disseminated cutaneous leishmaniasis with tuberculous dactylitis.
Maleki Masoud; Naghibi Masih; Sabouri-Rad Sara; Sardar Akram
Volume 17, Issue 1 , 2014, , Pages 18-21
Abstract
Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, ...
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Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, in 2001-2002.Method: This descriptive study was performed on 322 recipients who were examined by a dermatologist for malignant skin tumors in the renal transplant unit. A questionnaire containing a detailed history of age, sex, and site of the lesion, time of transplantation, occupation, and time of cancer development was completed for patients with a biopsy proven skin cancer.Result: Nine patients (2.8%) had malignant skin tumors. Five patients (55.55%) had Kaposi sarcoma (KS) and 4 patients (44.44%) had non melanoma skin cancer (NMSC). The mean age of the patients was 44.4 ±11.4 years. Eight patients (88.88%) were male. The mean time to development of Kaposi sarcoma and NMSC development was 9.1 months and 5.75 years, respectively. Three patients (60%) with Kaposi sarcoma had lesions on lower extremities and all the NMSCs were located in the head and neck region. Outdoor occupations were seen in at least 50% of NMSCs.Conclusion: This study again showed the importance of regular dermatologic examination for early diagnosis of skin malignancies, particularly, in high risk groups including renal transplant recipients.
Shamsi Hamid; Minoo Shaddel; Yakhchali Mohammad; Akbarzadeh Mahdi; Raoufi Nasrin; Tavakoli Payman; Dastgheib Mona; Dastgheib Mani
Abstract
Background: According to the drug resistance and side effects of the standard treatments for leishmaniasis, achieving effective treatment with less side effects and more benefits is of paramount importance. The present study aimed to evaluate the effect of Aloe vera leaf exudate on Leishmania major under ...
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Background: According to the drug resistance and side effects of the standard treatments for leishmaniasis, achieving effective treatment with less side effects and more benefits is of paramount importance. The present study aimed to evaluate the effect of Aloe vera leaf exudate on Leishmania major under in vitro and in vivo models, in inbred BALB/c mice. Methods: Different concentrations of both Aloe vera leaf exudates (AVL) and the standard drug meglumine antimoniate (Glucantime®;Sanofi-Aventis, France) were prepared (9.375l, 18.75, 37.5, 75, 150, and 300 ?g/ml) for in vitro model and then were applied to the fixed number of promastigotes. The promastigotes were counted after 24, 48, and 72 h. The viability of promastigotes was tested by MTT. A total of 20 mice with cutaneous leishmaniasis were divided into four groups for in vivo model, 1: positive group (treatment with Glucantime®), 2: negative group (without treatment), and 3 and 4: experimental groups (treatment with AVL1% and AVL4%, respectively). The size of the ulcers were recorded at the beginning of the experiment on a weekly basis for four weeks. Results: The results of in vitro model indicated that both AVL and Glucantime® reduced the number of promastigotes such that there was the lowest number of parasites in the concentration 300 ?g/ml of AVL and Glucantime®; however, the difference between them was not statistically significant. In vivo model demonstrated that AVL4% and Glucantime® decreased significantly the size of ulcers more than negative (P=0.000) and AVL1% groups (P=0.000 and P=0.004, respectively). Conclusions: There was no significant difference between AVL4% and Glucantime® (P=0.634). Therefore, AVL could control the Leishmania major.
M Emad; SMN Hosseini
Volume 3, Issue 3 , 2000, , Pages 18-22
Abstract
Background: Seborrheic dermatitis is one of the most common skin diseases. Objective: The purpose of this study was to compare the topical and oral ketoconazole in treatment of intractable cases of seborrheic dermatitis referring to Faghihi Hospital in Shiraz. Patients and Methods: This study was performed ...
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Background: Seborrheic dermatitis is one of the most common skin diseases. Objective: The purpose of this study was to compare the topical and oral ketoconazole in treatment of intractable cases of seborrheic dermatitis referring to Faghihi Hospital in Shiraz. Patients and Methods: This study was performed on 80 cases of intractable seborrheic dermatitis in 1376-1378. The patients were randomized in two treatment groups. Group included 40 patients who were treated with topical ketoconazole cream 2% two times per day for 4 weeks, and group 2 included 40 patients who received oral ketoconazole 200 mg daily for 4 weeks. Results: Topical ketoconazole clinically cured 35 (87.5%) and oral ketoconazole cured 38 (95%) of patients. This difference was not statistically significant. However topical ketoconazole was accompanied with a lower frequency of side effects than the systemic form. Conclusion: Both topical and oral ketoconazole can be regarded as a highly effective and safe treatment for seborrheic dermatitis.
Sh Enshaieh; A Kiani; A Yazdani
Volume 6, Issue 3 , 2003, , Pages 19-23
Abstract
Background: It seems that psychological factors have important role in beginning or exacerbation of psoriasis. On the other hand, psoriasis negatively impacts quality of lives of the patients. Objective: To determine the frequency of depression and anxiety disorders in psoriatic patients. Patients and ...
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Background: It seems that psychological factors have important role in beginning or exacerbation of psoriasis. On the other hand, psoriasis negatively impacts quality of lives of the patients. Objective: To determine the frequency of depression and anxiety disorders in psoriatic patients. Patients and Methods: In this descriptive study we evaluated 83 psoriatic patients referred to dermatologic clinics in Isfahan from 1379 to 1380. Beck and zoonge questionnaires were completed by the patients to evaluate depression and anxiety, respectively. Analysis of data was done by SPSS program with 95% confidence interval. Results: The frequency of depression in the patients was 69.9%. The most common type of depression was “Relative depression” (26.5%). The frequency of anxiety in psoriatic patients was 20.5%. These figures are higher than that reported in general population in Isfahan. Conclusion: The frequencies of depression and anxiety disorders in psoriatic patients were higher than general population. There was a direct correlation between the duration of disease and the prevalence of depression and anxiety disorders.
M Mirshams Shahshahani; E Aboo Saeidi
Volume 8, Issue 1 , 2004, , Pages 19-23
Abstract
Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal ...
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Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal nevus referred to skin clinic in Razi Hospital in Tehran whose diagnoses were confirmed by pathology examination, were treated with topical tretinoin 0.05% and 5FU 5%. Five patients were excluded because of loss to follow up and 10 patients were regularly followed. Results: Four patients were male and 6 of them were female. Their age ranged from 12 to 40 years. After 10 weeks, their nevi were flattened considerably so the patients were satisfied. There was no complication that needed to stop the treatment completely. Maintenance treatment was recommended and no recurrence was seen until the end of follow up duration. Conclusion: Topical tretinoin 0.05% and 5FU 5% are easy and inexpensive treatments for epidermal nevi, with satisfactory results and long maintenance therapy will prevent recurrence.
Edouard Grosshans
Volume 1, Issue 2 , 1998, , Pages 19-21
S Shamsoddini; VR Sepehr
Volume 5, Issue 4 , 2002, , Pages 20-27
Abstract
Background: Alopecia areata has a wide range of different clinical presentations. It may present as localized or diffuse hair thinness without hair loss, a small patch of hair loss or may progress to alopecia totalis and universalis. Objectives: Determination of clinical patterns of alopecia areata in ...
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Background: Alopecia areata has a wide range of different clinical presentations. It may present as localized or diffuse hair thinness without hair loss, a small patch of hair loss or may progress to alopecia totalis and universalis. Objectives: Determination of clinical patterns of alopecia areata in Kerman province and to compare the results with other studies in other countries. Patients and Methods: 952 patients with alopecia areata out of 25186 new cases referred to skin clinics in Kerman from June 2000 till June 2002 were evaluated for age, sex, family history of alopecia areata, extent of hair loss and history of infectious diseases. Results: 3.78% of all new cases referred to skin clinics suffered from alopecia areata. The male to female ratio was 2.6 to 1 and the most frequent clinical presentation of alopecia was round to oval type. Hair loss was confined to the scalp in 252 cases (26.5%). 216 cases (22.7%) had body hair loss without scalp alopecia, and 484 patients (50.8%) developed a combination of scalp and body hair loss. The combination pattern was significantly more frequent in the first three decades of life. Conclusion: Alopecia areata has a relatively high prevalence in Kerman province. It involves both scalp and body in the majority of cases especially in the first three decades of life.
Maryam Sadat Sadati; Nahid Hemmatian Boroujen; Mozhdeh Sepaskhah
Abstract
Subcutaneous fat atrophy at the site of multiple injections can follow intradermal or intramuscular administration of steroids to treat inflammatory diseases. This condition takes several months to develop, and usually patients seek medical attention due to cosmetic deformities. Several methods, including ...
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Subcutaneous fat atrophy at the site of multiple injections can follow intradermal or intramuscular administration of steroids to treat inflammatory diseases. This condition takes several months to develop, and usually patients seek medical attention due to cosmetic deformities. Several methods, including fat transfer, filler injection and normal saline injection haven been proposed to treat steroid-induced atrophy. However, no standard procedure has been established for normal saline injection in terms of quantity and time interval between sessions. Normal injectable saline was administered every other week for 3 months, followed by 3 months’ rest. During follow-up, the response was satisfactory. As far as the authors are aware, this is the first demonstration of this method’s applicability to cases of steroid-induced atrophy in pediatric settings.
Pouran Layegh; Mohammad Javad Mojahedin; Parisa Emamgholitabar Malekshah; Fatemeh Nazemian; Farzaneh Sharifipour; Mohammad Vahedian
Volume 10, Issue 1 , 2007, , Pages 20-25
Abstract
Background and aim: Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of ...
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Background and aim: Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of chemotherapy induced nausea. There are some studies about effect of Ondansetron in uremic pruritus and recently one case report described relief of renal itch with Granisetron. The aim of our study was to evaluate the effect of Granisetron on uremic pruritus in patients with chronic renal failure under dialysis.Materials and methods: 14 uremic patients under hemodialysis with moderate and severe pruritus were enrolled in this open trial. Patients received Granisetron tablet (1 mg twice a day) for 1 month. Patients were asked to complete a questionnaire assessing the severity of pruritus on twice a day.Results: 77% of the patients responded to the treatment and on the 1st , 2nd and 4th weeks of treatment, the mean values of pruritus score were 23 (range 11-40), 16(range 8-35), 8(range 0-35) points, respectively, while at baseline (before treatment) it was 31 (range 20-35) points (p=0.03). Pruritus disappeared in 7 patients at the end of 4th week, and was mild in 3 others. This effect was maintained during the study. Weekly clinical and laboratory examinations showed no side effects.Conclusion: Granisetron may be an effective, safe and well tolerated drug for the treatment of uremic pruritus in hemodialysis patients.
