A Momeni; A Asilian; M Meghdadi; Sh Enshaieh; F Shariati; MA Nilforoush Zadeh; F Iraji; F Fatemi; M Amin Javaheri
Volume 2, Issue 1 , 1998, , Pages 21-26
Abstract
Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark ...
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Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark features of this syndrome are: Fever, rash and lymphadenopathy. The epoxide hydrolase enzyme may be lacking or mutated in persons in whom AHS develops. The reaction may be genetically determined and familial occurrence of hypersensitivity was observed. The timely recognition of AHS is important, because accurate diagnosis avoids potentially fatal re-exposure and affects subsequent anticonvulsant treatment options. We report two cases of AHS and review the clinical and pathophysiologic features.
F Farnaghi; H Seyrafi; N Zarrinpour
Volume 6, Issue 1 , 2002, , Pages 21-25
Abstract
Background: Hirsutism is a common clinical problem with different etiologic factors. Hence, clinical and laboratory studies are necessary to find these factors. Objectives: To determine the etiologic factors of hirsutism with clinical and paraclinical studies including TSH, DHEA-S, LH/FSH, testosterone, ...
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Background: Hirsutism is a common clinical problem with different etiologic factors. Hence, clinical and laboratory studies are necessary to find these factors. Objectives: To determine the etiologic factors of hirsutism with clinical and paraclinical studies including TSH, DHEA-S, LH/FSH, testosterone, prolactin, 17-OH progesterone and sonography of ovary. Patients and Methods: This cross sectional study evaluated clinical and paraclinical findings of 110 hirsute patients who referred to the dermatology clinic of Tehran Razi Hospital during a period of one and half years, in 2000-2001. Results: Polycystic ovary syndrome (PCOs) was diagnosed in 54 patients (49%) including 14 cases (26%) with regular menstruation. 43 patients (39%) had laboratory findings compatible with PCOs and LH/FSH>3 was the most valuable one in 41 patients (37%). 53 patients (48%) with regular menstrual cycles and normal laboratory and sonographic findings had idiopathic hirsutism. Late onset adrenal hyperplasia due to partial 21-hydroxylase deficiency was diagnosed in two cases (1.8%). In one patient with irregular menstruation, pituitary prolactinoma was confirmed by brain imaging techniques. Conclusion: Routine laboratory evaluations are mandatory in the management of hirsutism, regardless of menstruation cycles.
L Dastgheib; P Peyravi
Volume 5, Issue 2 , 2002, , Pages 22-27
Abstract
Background: Pruritic dermatoses of pregnancy are important and common dermatoses during pregnancy. Objective: The purpose of this study was to determine the incidence and specificity or non-specificity of pruritic dermatoses of pregnancy and their effects on health of mother and fetus, during a period ...
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Background: Pruritic dermatoses of pregnancy are important and common dermatoses during pregnancy. Objective: The purpose of this study was to determine the incidence and specificity or non-specificity of pruritic dermatoses of pregnancy and their effects on health of mother and fetus, during a period of one year. Patients and Methods: The data were gathered by questionnaires completed by midwives in two antenatal clinics in Shiraz from October 1999 to October 2000. The pregnant patients with pruritic dermatoses were referred to dermatology outpatient clinic and evaluated according to their history, physical examination and laboratory workups. Results: Twenty-five patients out of 9500 pregnant women had pruritic lesions, so the incidence rate was 0.26%. Pruritic urticarial papules and plaques of pregnancy and eczema were the most common dermatoses. One mortality and two morbidities in neonates of these mothers were observed. Conclusion: Because dermatoses of pregnancy are common and important diseases which can affect the health of both mother and fetus, further research in this field is necessary.
A Asilian; MR Omid Ghaemi; A Momeni; F Iraji
Volume 5, Issue 3 , 2002, , Pages 22-28
Abstract
Background: Acitretin therapy is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin reduced isotretinoin-induced side effects. Objective: The purpose of this clinical trial study was to determine the effect of ...
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Background: Acitretin therapy is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin reduced isotretinoin-induced side effects. Objective: The purpose of this clinical trial study was to determine the effect of a fixed or adjusted dose of vitamin E on the side effects of acitretin. Patients and Methods: Fifty five subjects were randomly assigned to one of the two treatment programs including with acitretin (0.7-1 mg/kg/day) together with either vitamin E (13 IU/kg/day) or alone for 3 months. The incidence of side effects of acitretin in two groups were assessed and compared. Results: The study was completed in thirty-nine patients. Vitamin E did not decreased the incidence of side effects associated with acitretin. Conclusion: Vitamin E did not significantly ameliorate retinoid side affects when combined with 0.7-1 mg/kg of acitretin in treatment of skin disorders.
H Riahi Dehkordi; AR Firooz
Volume 2, Issue 4 , 1999, , Pages 22-30
Abstract
Systemic drugs have been used widely in the treatment of many skin diseases. Although dermatologists are familiar with the guidelines of selecting appropriate patients and prescribing systemic drugs, their knowledge about the side effects and significant interactions of systemic drugs used in dermatology ...
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Systemic drugs have been used widely in the treatment of many skin diseases. Although dermatologists are familiar with the guidelines of selecting appropriate patients and prescribing systemic drugs, their knowledge about the side effects and significant interactions of systemic drugs used in dermatology is more limited. So a short review on important drug interactions seems to be useful. Some of the most significant drug interactions in dermatology are reviewed.
MA Mapar; H Nazari; Kh Siavashi
Volume 3, Issue 4 , 2000, , Pages 23-28
Abstract
Background: Determination of the prevalence of diseases is an important step in health programs. Objective: To determine the prevalence of skin diseases in primary school students in Ahwaz. Patients and Methods: This cross-sectional study was done in March and April 1995 (Esfand 1373, Farvardin 1374) ...
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Background: Determination of the prevalence of diseases is an important step in health programs. Objective: To determine the prevalence of skin diseases in primary school students in Ahwaz. Patients and Methods: This cross-sectional study was done in March and April 1995 (Esfand 1373, Farvardin 1374) in Ahwaz. 3000 male and 3000 female primary school students were examined for the presence of skin disease by a physician. This sample comprised 5 percent of total primary school students of Ahwaz. Diagnosis was made on clinical findings, laboratory examinations and skin biopsy, if needed. Results: The most common skin diseases were: pityriasis alba, acne, freckle, keratosis pilaris, pediculosis capitis, chicken pox, wart, impetigo, herpes simplex and leishmaniasis. The most common diseases in girl were acne and pediculosis capitis and in boys were acne and warts. Also the prevalence of diseases was related to the economic status of students. Conclusion: Skin diseases are common in primary school students in Ahwaz. The prevalence of certain skin diseases was related to the sex and economic status of the students.
MA Mapar; H Kavoosi; MA Dabbagh
Volume 4, Issue 4 , 2001, , Pages 23-28
Abstract
Background: Cutaneous leishmaniasis (CL) is a common cutaneous disease in the middle-east countries such as Iran. Khoozestan is an endemic area for it. The importance of this disease is in the formation of an ugly scar on the face, which damages beauty. There hasn’t been any effective topical treatment ...
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Background: Cutaneous leishmaniasis (CL) is a common cutaneous disease in the middle-east countries such as Iran. Khoozestan is an endemic area for it. The importance of this disease is in the formation of an ugly scar on the face, which damages beauty. There hasn’t been any effective topical treatment for this disease yet. Objective: To assess the effect of topical opium in the treatment of CL. Patients and Methods: A double blind, placebo controlled study was performed in Ahwaz during 1378 and 1379. 96 patients were included in this study and treated with a topical preparation of opium or placebo. The inclusion criteria for patient were: age more than 2 years, number of lesion less than 6, duration of disease less than 3 months, not using any drug with anti-leishmaniasis effect and positive direct smear. Pregnant or nursing patients were excluded. Results: From 58 patients who completed the study, 34 patients were given topical opium, 5 (4.2%) of them got cured. From 24 patients who were given placebo, only 1 (4.2%) patient got cured. This study did not show a significant difference between response to drug and placebo (P=0.12, chi-square test). Conclusion: From this study suggested that high concentration of topical opium or combination of topical opium with other material to be carried out.
N Bouzari; AR Firooz; H Tabatabai; Y Dowlati
Volume 4, Issue 3 , 2001, , Pages 24-29
Abstract
Background: Minoxidil is currently an approved treatment for androgenetic alopecia. Topical tretinoin can enhance skin absorption of minoxidil. Objective: This study has been done in order to determine the efficacy and safety of the solution of 0.5% minoxidil+0.05% tretinoin compared to 2% minoxidil ...
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Background: Minoxidil is currently an approved treatment for androgenetic alopecia. Topical tretinoin can enhance skin absorption of minoxidil. Objective: This study has been done in order to determine the efficacy and safety of the solution of 0.5% minoxidil+0.05% tretinoin compared to 2% minoxidil in androgenetic alopecia in men. Patients and Methods: In a randomized, double-blind, parallel-group, controlled study, 117 male patients with androgenetic alopecia, 18-40 years old, Hamilton grades of 2-5 and duration of alopecia less than 10 years were evaluated. These patients were divided in two groups randomly, one group received a solution containing 0.5% minoxidil and 0.05% tretinoin and another group received 2% minoxidil for at least 4 months. The patients used 1ml of the solution twice daily. 2 and 4 months after treatment, the patients were evaluated for efficacy (Patients, idea about improvement of hair loss, hair regrowth and wash test) and safety (Erythema, scaling and pruritus). The quantitative data were analyzed by ANOVA and the qualitative data were analyzed by qui-squared test. Results: There were no significant differences between two groups regarding the age, duration and grade of hair loss. After 4 months of treatment, the percentage of patients reporting improvement in hair loss and hair regrowth were 81.6% and 56% in minoxidil 2% group and 65.4% and 59.6% in minoxidil+tretinoin group, respectively (P>0.05 for all). At the same time, the numbers of hairs in wash test were 156 in minoxidil 2% group and 149 in minoxidil+tretinoin group (P>0.05). Conclusion: There was no significant difference in efficacy and safety of 4 months treatment with the solution of 0.5% minoxidil and 0.05% tretinoin compared to the solution of 2% minoxidil in the treatment of androgenetic alopecia in men.
A Momeni; A Khamesipour; A Bagher Zadeh; M Amin Javaheri
Volume 3, Issue 1 , 1999, , Pages 24-30
Abstract
Background: Cell-mediated immunity (CMI) plays an important role in resistance against leishmaniasis. Leishmanin test (Montenegro skin test) is a method in evaluation of immune system reaction against cutaneous leishmaniasis. The TDR/WHO reference Leishmanin produced by the Pasteur Institute of Iran ...
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Background: Cell-mediated immunity (CMI) plays an important role in resistance against leishmaniasis. Leishmanin test (Montenegro skin test) is a method in evaluation of immune system reaction against cutaneous leishmaniasis. The TDR/WHO reference Leishmanin produced by the Pasteur Institute of Iran is used worldwide. Two other antigens produced by Razi Serum Institute of Iran, Killed Leishmania Major (K.L.M) and Autoclaved Leishmania Major (A.L.M), take advantage of vaccine strains of L.major, and under supervision of WHO, have been investigated as leishmaniasis vaccine. Objective: KLM, ALM and standard Leishmanin as skin test wee compared in this study. Patients and Methods: Fifty patients with cutaneous leishmaniasis were randomly selected. They attended the educational clinics of Isfahan University of Medical Sciences. All 3 antigens were injected intradermally in them and the size of erythema and induration were read and recorded after 48 hours. Data were grouped and analyzed with analysis of variance (ANOVA). Results: There was significant difference between mean of erythema and induration sizes of antigens in two by two comparison. The mean of erythema and induration sizes due to K.L.M were greater than A.L.M, and mean of erythema and induration sizes due to A.L.M were greater than Pasteur Institute reference leishmanin (P<0.0001). Conclusion: Although the mean of erythema and induration sizes due to K.L.M were greater than others, use of A.L.M seems to be more practical compared to. K.L.M, because of simple storage method of A.L.M, and more sensitive than Pasteur Institute reference leishmanin.
MJ Nazemi; S Arad; H Haji Hosseini; AH Ehsani
Volume 6, Issue 4 , 2003, , Pages 24-27
Abstract
Background: Comedone formation has an essential role in pathophysiology of acne, therefore destroying of comedones and preventing of comedone formation is very important in acne treatment. Objective: To determine the effect of superficial peeling with 70% glycolic acid in the improvement of acne. Patients ...
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Background: Comedone formation has an essential role in pathophysiology of acne, therefore destroying of comedones and preventing of comedone formation is very important in acne treatment. Objective: To determine the effect of superficial peeling with 70% glycolic acid in the improvement of acne. Patients and Methods: In this open clinical trial without control group, 30 patients with acne referred to Razi Hospital in Tehran (Mean age 18) years were treated with 70% glycolic acid and their clinical improvement was evaluated. Results: Mean numbers of comedones were 24.4±15.2 and 2.6±5.9 in first and last visits respectively (P<0.005). Moreover, 18 patients (60%) and 12 patients (40%) had complete and relative improvement, respectively. The side effects of this treatment were minimum and transient. Conclusion: Superficial peeling with 70% glycolic acid is effective in treatment of mild acne.
M Motavali Emami; MA Nilforoosh Zadeh; M Yazdi
Volume 7, Issue 1 , 2003, , Pages 24-28
Abstract
Background: Increasing in the prevalence of pediculosis among school students and upward trend of pesticide marketing with evidence of resistance to them, indicate the possibility of lice resistance. Objective: To compare 3 drug formulations including: Lindan shampoo 1%, permethrin shampoo 1% and Copex ...
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Background: Increasing in the prevalence of pediculosis among school students and upward trend of pesticide marketing with evidence of resistance to them, indicate the possibility of lice resistance. Objective: To compare 3 drug formulations including: Lindan shampoo 1%, permethrin shampoo 1% and Copex powder 0.5% in the treatment of head lice infestation. Patients and Methods: Ninety students with a confirmed diagnosis of pediculosis were selected from rural schools and randomly treated in 3 equal groups with the mentioned medications. The results were evaluated after 24 hours, 1, 2 and 6 weeks. Results: The rate of healing was 83.3%, 100%, 100% after 24 hours, 70%, 93.3%, 90% after 1 week, 63.3%, 90%, 76.7% after 2 weeks and 40%, 83.3%, 66.7% after 6 weeks in patients treated with Lindan, permethrin, and Copex powder, respectively (P<0.05, chi-square test). Conclusion: Considering the numerous side effects of current treatment options like Lindan, alternative treatments must be trailed especially in fall and winter because of high rate of infestation during these seasons to interfere with resistancy.
F Zandi; S Shamsaddini; N Kambin
Volume 2, Issue 3 , 1999, , Pages 25-30
Abstract
Molluscum contagiosum is an infectious viral disease. The necessity to do this research in primary school of Kerman is mainly based on the high occurrence of the molluscum contagiosum (MC) among children, though an increase of the incidence of MC in adults with AIDS and immune deficiencies has also been ...
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Molluscum contagiosum is an infectious viral disease. The necessity to do this research in primary school of Kerman is mainly based on the high occurrence of the molluscum contagiosum (MC) among children, though an increase of the incidence of MC in adults with AIDS and immune deficiencies has also been reported. Among 1181 girls and 1440 boys, 75 were infected with MC; 29 (2.45%) and 46 (3.1%) cases were infected respectively, however these differences were not statistically significant. The effect of factors such as age, sex, parent’s level of education and occupation, and the size of family on the incidence of MC were studied. In this research the overall incidence of MC was 2.9%, but the highest rate of incidence was among children at the age of 6. Furthermore the incidence among children in public schools were more than private schools and children from families with low education and also larger families was higher, though these differences were not statistically significant.
A Asilian; A Sadeghinia; F Shariati; SM Emam Jome; AR Ghoddusi
Volume 6, Issue 2 , 2003, , Pages 25-29
Abstract
Background: Some researchers claim that permethrin-impregnated clothes are effective in the prevention of cutaneous leishmaniasis. Objectives: To determine the effectiveness of permethrin-impregnated clothes in the prevention of cutaneous leishmaniasis. Patients and Methods: 272 soldiers were randomized ...
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Background: Some researchers claim that permethrin-impregnated clothes are effective in the prevention of cutaneous leishmaniasis. Objectives: To determine the effectiveness of permethrin-impregnated clothes in the prevention of cutaneous leishmaniasis. Patients and Methods: 272 soldiers were randomized in two groups. In one group permethrin-impregnated clothes and in the other group, control clothes were used. In each group the clothes were worn during days and nights for three months and the soldiers were followed for additional 6 months. Results: 9 (6.5%) of 138 soldiers wearing control clothes and 6 (4.4%) of 134 soldiers wearing permethrin-impregnated clothes acquired cutaneous leishmaniasis. The difference between two groups was not statistically significant. Conclusion: Permethrin-impregnated clothes are not effective in the prevention of cutaneous leishmaniasis.
M Farshchian; M Pilevar
Volume 4, Issue 1 , 2000, , Pages 26-30
Abstract
Background: Pityriasis rubra pilaris (PRP) is a rare skin disease characterized by follicular hyperkeratosis, perifollicular erythema with islands of normal skin scattered over the sheets of erythroderma, palmoplantar hyperkeratosis and pityriasis capitis with unknown etiology. Objective: This study ...
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Background: Pityriasis rubra pilaris (PRP) is a rare skin disease characterized by follicular hyperkeratosis, perifollicular erythema with islands of normal skin scattered over the sheets of erythroderma, palmoplantar hyperkeratosis and pityriasis capitis with unknown etiology. Objective: This study has been done in order to determine the demographics, clinical and therapeutic aspects of PRP patients who were admitted to the dermatology ward of Sina Hospital in Hamadan in 1991-1999. Patients and Methods: This was a case series study, which the essential information was gathered by referring to the patients’ files. Then the obtained information was analyzed by SPSS software. Results: As PRP is a rare disease. Only 8 patients were identified. Five of them (61.5%) were men and 3 (37.5%) were women. The highest age of PRP patients was 66 years and the lowest was seven. The mean age of the patients was 32±19.4 years. None of the patients mentioned a positive family history. Six (75%) of the PRP patients suffered from Type I and two patients (25%) from Type III. Five patients (62.5%) were completely cured, all treated with retinoids, and three patients (37.5%) were partially cured, all treated with methotrexate. There was no case showing failure of the treatment. Conclusion: In this study the number of men was more than women. All of our patients suffered from Type 1 adult onset (Classic) or Type III juvenile onset. Retinoids showed more efficacy than methotrexate in the treatment of PRP.
S Shamsoddini
Volume 3, Issue 2 , 2000, , Pages 27-34
Abstract
Here are our meditation on the art of attracting, keeping, and helping patients. It contains some sections including “Be professional”, “Be reassuring”, “Be confident”, “Be informative”, “Be smart” and “Be responsive”.
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Here are our meditation on the art of attracting, keeping, and helping patients. It contains some sections including “Be professional”, “Be reassuring”, “Be confident”, “Be informative”, “Be smart” and “Be responsive”.
M Farshchian; A Zamanian
Volume 5, Issue 1 , 2001, , Pages 27-33
Abstract
Background: Behcet’s disease is a recurrent, chronic and multi-systemic disease, which is determined by mucocutaneous manifestations. It spreads all over the world. The most common areas are in the Middle East, Mediterranean and Far East. Objective: The aim of this study was to determine the frequency ...
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Background: Behcet’s disease is a recurrent, chronic and multi-systemic disease, which is determined by mucocutaneous manifestations. It spreads all over the world. The most common areas are in the Middle East, Mediterranean and Far East. Objective: The aim of this study was to determine the frequency of clinical manifestations of Behcet’s disease in patients admitted to dermatology ward of Sina Hospital in Hamadan city in 1991-1999. Patients and Methods: This study was a descriptive retrospective cross-sectional study, which the essential information including sex, age and clinical manifestations were gathered by referring to the patients’ files. Then the obtained information were analyzed by EPI info6 software. Results: Twenty-eight patients were identified. Thirteen patients (46.6%) were female and 15 patients (53.6%) were male. The most common age was in the third decade. The average age of the patients at the beginning of disease was 31.89±12.95 years. Skin involvement was observed in 11 patients (39.9%). Nine patients (32.1%) had folliculitis, 5 patients (17.9%) had papulopustular lesions, 2 patients (7.1%) had erythema nodosum like lesions. Conclusion: This study showed that skin involvement (Particularly erythema nodosum like lesions, papulopustular lesions and positive pathergy test) and also articular symptoms were less common in patients in Hamadan than other parts of world. But the frequency of other clinical manifestations of Behcet’s disease were nearly equal to other studies.
MH Amouzgar; MJ Yazdan Panah; M Ebrahimi Rad
Volume 9, Issue 1 , 2006, , Pages 28-34
M Radmanesh; S Shafiei
Volume 1, 3-4 , 1998, , Pages 34-37
Abstract
Background: Thirty to forty percent of the patients referred to dermatologic clinics are estimated to have psychiatric problems. These patients either are those who have developed dermatologic problems as a consequence of their primary psychiatric disorders or those who have developed psychiatric disorders ...
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Background: Thirty to forty percent of the patients referred to dermatologic clinics are estimated to have psychiatric problems. These patients either are those who have developed dermatologic problems as a consequence of their primary psychiatric disorders or those who have developed psychiatric disorders following their chronic and disfiguring dermatologic problems. The third group are psychophysiologic disorders which may aggravate following psychiatric or emotional stress. Objectives: Our purpose is to stress the significance of the psychodermatologic problems for both dermatologists and psychiatrists; to have an overview and a brief classification of these and discussing the approach to the patients with psychodermatologic disorders. Methods: The dermatologists and psychiatrists’ pitfalls in approaching the psychodermatologic disorders are discussed. Psychodermatologic disorders are classified and their underlying psychopathologies are mentioned. Conclusion: Both dermatologists and psychiatrists should be trained more to manage these relatively frequent patients well; for this purpose establishing the dermatology-psychiatry liaison clinics and or helding the dermatologic-psychiatric conferences are advised.
SK Alavi Fazel; SM Radmanesh
Volume 2, Issue 2 , 1999, , Pages 34-38
Abstract
Hypnotherapy is recommended for recalcitrant cases of many dermatologic disorders including viral warts, chronic urticarias, psoriasis and alopecia areata. A 23-year old, married lady referred with five years history of confluent verrucous and cauliflower type of viral warts on the dorsum of right foot ...
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Hypnotherapy is recommended for recalcitrant cases of many dermatologic disorders including viral warts, chronic urticarias, psoriasis and alopecia areata. A 23-year old, married lady referred with five years history of confluent verrucous and cauliflower type of viral warts on the dorsum of right foot and many discrete warty papules on the left foot and toes and on different aspects of both hands and fingers. She had tried many medical modalities and surgical procedures including: keratolytics, formalin application, electrocauterization, curettage, cryotherapy with no satisfactory effect. As the patient was quite frustrated with no more trust on physical therapies, she was advised to be treated by hypnotherapy. After patient’s consent, she was scheduled for 20 hypnotherapy sessions with weekly interval. The papules on the hands disappeared after the second session and those of the right foot started to improve after the tenth session. Complete eradication occurred before the 20th session. Although hypnotherapy is time consuming, it is recommended for recalcitrant cases of viral warts.
S Shamsadini; M Saba; F Shamsadini
Volume 1, Issue 1 , 1997, , Pages 38-42
Abstract
Pachydermoperiostosis (PDP) is a rare hereditary disease characterized by folded coarse skin, hyperostosis, clubbing of fingers and abnormalities in other organs such as gastrointestinal tract. Because of safety parents guides us to familial incidence and penetration of gene in 50% of cases. Diagnosis ...
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Pachydermoperiostosis (PDP) is a rare hereditary disease characterized by folded coarse skin, hyperostosis, clubbing of fingers and abnormalities in other organs such as gastrointestinal tract. Because of safety parents guides us to familial incidence and penetration of gene in 50% of cases. Diagnosis is based on clinical and radiological findings. Males are more susceptible than females to this disease. This is the report of primary PDP in two brothers whose parents were net affected. Therapy in this syndrome is symptomatic, and using of low dose colchicine was not effective in this case.
Hassan Iffat; Sajad Peerzada; Jahangir Majid
Volume 15, Issue 2 , 2012, , Pages 47-49
Abstract
Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys ...
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Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys and other organs may be involved. Our aim was to evaluate skin thickness and echogenicity in systemic sclerosis patients by ultrasound and compare it with the healthy age and sex matched controls. Method: Our study included 15 successively admitted patients (14 females and 1 male) with systemic sclerosis and 15 healthy age and sex matched controls. All the patients met the ACR criteria of diagnosis. The age range of the patients was 25-55 years. The disease duration ranged from 1-8 years. A complete history and physical examination was done for each patient. Skin thickness and echogenicity were measured by a 20MHz ultrasound probe at 6 different anatomical sites which was compared with that of the controls. Result: Skin thickness was more in systemic sclerosis patients (significant p value) as compared to controls, and echogenicity was inversely proportional to the skin thickness. Conclusion: Skin ultrasonography is a noninvasive method which can reflect the severity of skin involvement and periodic assessment of skin thickness and echogenicity can help to monitor the progression of the disease.
Farideh Golforoushan; Hamideh Azimi; Mohamad Sadeghi; Neda Yousefi; Mohamad Goldust
Volume 13, Issue 2 , 2010, , Pages 47-50
Abstract
Introduction: Solar lentigo is local and benign proliferation of melanocytes which is common in old individuals and creates a major concern considering beauty. Despite several and somehow expensive treatments such as laser and cryotherapy, chemical peeling with Trichloroacetic Acid (TCA) has recently ...
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Introduction: Solar lentigo is local and benign proliferation of melanocytes which is common in old individuals and creates a major concern considering beauty. Despite several and somehow expensive treatments such as laser and cryotherapy, chemical peeling with Trichloroacetic Acid (TCA) has recently attracted attentions considering its low cost and availability. The present study was designed to compare the efficacy and side effects of Trichloroacetic Acid (TCA) 35% and cryotherapy in the treatment of solar lentigo.Methods: This randomized clinical trial was performed on 35 individuals with solar lentigo on their hands. First, images were taken from both hands. Then, one side was treated with cryotherapy and the other side was treated with TCA 35%, randomly. This treatment was repeated after one month. The imaging was repeated at the end of the second month and both sides were compared with previous images regarding the degree of the improvement (lightening) of the lesions and the resultant side effects. Descriptive statistical methods and 2-chi square relation were used for analyzing data with SPSS 16.Results: The results demonstrated that cryotherapy resulted in more than 50% recovery (lightening >50%) in 60% of the cases which was statistically significant (P<0.05). In contrast, TCA 35% yielded more than 50% recovery in 46% of the cases which was significant, too. Comparing these modes of treatments regarding 50% recovery showed no statistically significant difference (P=0.219). Side effects were seen in 40% and 13.3% of the individuals who used cryotherapy and TCA 35%, respectively, which was statistically significant (P<0.05).Conclusions: According to the findings of the research, TCA 35%, compared to cryotherapy, has similar efficiency but fewer side effects in the treatment of solar lentigo.
Aminian Neda; Momeni Mahnoush; Ranjpoor Faraz; Eidipoor Hoda; Rahbar Hossein
Volume 19, Issue 2 , 2016, , Pages 50-53
Abstract
Background: Treatment of a diabetic foot is a principal step in rehabilitative approaches to the complications of diabetes mellitus. Use of integrative educational courses for diabetic patients is dependent on several factors such as cultural entities of the population, patient perceptions of classes, ...
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Background: Treatment of a diabetic foot is a principal step in rehabilitative approaches to the complications of diabetes mellitus. Use of integrative educational courses for diabetic patients is dependent on several factors such as cultural entities of the population, patient perceptions of classes, and their previous trainings about diabetes and related complications. The aim of this study was to determine the efficacy of integrative programs to improve diabetic patients’ outcomes for wound care. Methods: We included 100 patients with diabetic wounds from August, 2014–December, 2014. Resources in this study included educational classes, brochures, and pamphlets. We implemented the educational course for three months in 50 patients and compared the results with 50 controls who received no educational course. The educational course was conducted over a three-month period and we evaluated reduction of HbA1C, fasting blood sugar (FBS), 60-second Diabetic Foot Screen score, STONES (Size, Temperature, Os [bone], New areas of breakdown, Exudate, erythema, edema, Smell) and NERDSS (Non-healing wound, Exudative wound, Red and bleeding wound, Debries in the wound, Smell form the wound) parameters implemented for evaluation of infectious diabetic wounds. Results: We followed STONES and NERDS changes (positive to negative) in 42 (84%) patients from the intervention group and 21 (42%) control group patients (P=0.001). Reduction in the 60-second Diabetic Foot Screen score was 34 (68%) for the intervention group and 24 (48%) in the control group (P=0.03). Conclusion: Possibly the use of interventional educational programs is effective in reduction of harm in patients with diabetic wounds, which will lead to decreased infections and better dynamic conditions.
Soheila Nassiri; Mojdeh Sarlak; Farahnaz Bidari Zereh Posh; Siamak Mirab Samiee; Farzaneh(Batool) Rahimi; Mehdi Qaisari
Volume 12, Issue 2 , 2009, , Pages 52-55
Abstract
Background: Anogenital wart is a common sexually transmitted disease affecting both genders. The aim of this study was to evaluate human papilloma virus types of anogenital warts with Polymerase Chain Reaction (PCR). Method: 65 formalin fixed paraffin embedded (FFPE) tissue blocks of the anogenital warts ...
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Background: Anogenital wart is a common sexually transmitted disease affecting both genders. The aim of this study was to evaluate human papilloma virus types of anogenital warts with Polymerase Chain Reaction (PCR). Method: 65 formalin fixed paraffin embedded (FFPE) tissue blocks of the anogenital warts obtained from the pathology lab of Loghman Hakim hospital were included in this study. Results: In 27 samples (41.5%), human papilloma virus was detected by PCR. In addition, low risk HPV types (6, 11) were identified in all samples without any positivity for high risk HPV types (16, 18, 31 and 33). Conclusion: By finding low risk HPV types in all samples, it could be concluded that Anogenital warts seems not to be precursors of anogenital malignancies.
Edalatkhah Hassan; Matin Elmira; Ahari Saeid Sadeghieh
Volume 20, Issue 2 , 2017, , Pages 54-58
Abstract
Background: Acne vulgaris has a multifactorial pathogenesis; however, the exact role of genetic predisposition is not clear. Some studies have reported an association between familiy historyof acne and moderate to severe acne. In this study, we investigated the relationship between familiy history and ...
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Background: Acne vulgaris has a multifactorial pathogenesis; however, the exact role of genetic predisposition is not clear. Some studies have reported an association between familiy historyof acne and moderate to severe acne. In this study, we investigated the relationship between familiy history and prevalence of acne vulgaris in girls 8 to 13 years of age.Methods: This case-control study enrolled 400 students. The participants were divided into two groups, case and control, with 200 students per group. The case group consisted of students with acne vulgaris and the control group included those without acne. The severity of acne was determined based on the Global AcneGrading Score (GAGS). The presence of acne in close relatives (father, mother, sister, brother) was determined through face to face interviews with participants’ mothers and phone contacts with other family members. All collected data were analyzed by SPSS software.Results: The case participants had a mean age of 10.62±1.71 years and those in the control group had a mean age of 10.54±1.70 years, which was not statistically significant. The mothers with acne vulgaris had the highest odds ratio (OR: 2.719, 95% CI: 1.788-4.133) between the case and the control groups. The ratio of encountering the probability with both parents developing acne vulgaris between the two groups was 2.346 (95% CI: 1.571-3.503).Conclusion: This study revealed a significant relationship between positive familial history of acne and prevalence of acne vulgaris.
