Nilforoushzadeh Mohammad Ali; Haftbaradaran Elaheh; Siadat Amir Hossein
Volume 10, Issue 3 , 2007, , Pages 240-244
Abstract
Cutaneous leishmaniasis is an endemic disease in Iran and there is no curative treatment. The disfiguring scar that remains after it subsides is a major psychologic and emotional problem in these patients. Chronic leishmaniasis is a rare form of this malady which is seen in 5-7 percent of cases. In this ...
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Cutaneous leishmaniasis is an endemic disease in Iran and there is no curative treatment. The disfiguring scar that remains after it subsides is a major psychologic and emotional problem in these patients. Chronic leishmaniasis is a rare form of this malady which is seen in 5-7 percent of cases. In this article we report a 46-year-old man who was refered to us for a large leishmaniasis lesion consisting of a scaling erythematous plaque with several papules on the right side of face and nose. This patient was treated by a combination of systemic Glucantime, 50% trichlroacetic acid and oral fluconazole. Complete resolution was achieved after 4 months.
A Rasi; R Soltani Arabshahi; Z Safaie Naraghi
Volume 7, Issue 4 , 2004, , Pages 264-270
Abstract
Circumscribed juvenile pityriasis rubra pilaris (PRP) is a form of PRP that manifests with well-defined erythematous scaly plaques with follicular keratosis mainly over knees and elbows. There are several reports of the association of PRP with other conditions. We report a boy with scattered erythematosquamous ...
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Circumscribed juvenile pityriasis rubra pilaris (PRP) is a form of PRP that manifests with well-defined erythematous scaly plaques with follicular keratosis mainly over knees and elbows. There are several reports of the association of PRP with other conditions. We report a boy with scattered erythematosquamous skin lesions and follicular hyperkeratotic papules since the age of six years. Skin biopsy was compatible with PRP. He also had hypoparathyroidism and brachyonychia. To our knowledge, this association has not been reported so far.
M Nasiri Kashani; H Mortazavi; S Amini
Volume 9, Issue 3 , 2006, , Pages 264-269
Abstract
Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact ...
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Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Methods: This descriptive, cross sectional study was performed on patients with contact or atopic dermatitis in 2003-2004 with European Standard Series patch test containing 24 allergens.Results: In this study 223 patients were tested with a mean age of 31 years (SD=12). The most common involved location was hand (59%). The most common allergens were nickel sulphate (23/2%), cobalt (11/4%) and thiuram (8/3%).Conclusion: Nickel sulphate was the most common contact allergen in this study.
A Rasi; H Ansarin; AR Khatami
Volume 8, Issue 4 , 2005, , Pages 299-306
Abstract
Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, ...
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Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathic thrombocytopenic purpura. IVIg treatment has been shown to be safe, without many drug-related adverse effects, including systemic immunosuppression, that are related to corticosteriods and other immunosuppressive agents. Current dermatologic uses of IVIg are increasing, which calls for adequately controlled clinical trials. This review evaluates the current published data on the use of IVIg therapy in the treatment of autoimmune diseases and discusses current opinion concerning its potential immunomodulating mechanisms, the industrial preparation and safety features of this biologic agent.
Kafaie Parichehr; Soghra Yassaei
Volume 10, Issue 4 , 2007, , Pages 329-112
Abstract
Contact dermatitis can affect dentists, orthodontists, technicians, nurses and the patients. The increase of dental patients in recent years caused an increase in reports of dermatitis and other allergies in patients and in dentists too. With changes in dental materials through years, allergy and contact ...
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Contact dermatitis can affect dentists, orthodontists, technicians, nurses and the patients. The increase of dental patients in recent years caused an increase in reports of dermatitis and other allergies in patients and in dentists too. With changes in dental materials through years, allergy and contact reactions in persons in contact with new allergens had been increased. So dentists and dermatologists should be aware of new allergens and try to avoid contact with these materials as possible. This review is performed to increase the knowledge of medical personnel about this issue with description of each allergen.
Amir Houshang Ehsani; Mahboubeh Sadat Hosseini; Alireza Mir Esmaili; Reza Nemati
Volume 9, Issue 4 , 2006, , Pages 355-359
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with different extra-articular manifestations. Among those extra-articular manifestations, there are significant cutaneous manifestations which may result in first admission to a dermatologist. In this article some specific and non-specific ...
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Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with different extra-articular manifestations. Among those extra-articular manifestations, there are significant cutaneous manifestations which may result in first admission to a dermatologist. In this article some specific and non-specific skin lesions of RA such as rheumatoid nodules, exacerbated nodules, rheumatoid vasculitis, Bywaters, pyoderma gangrenosum and neutrophilic rheumatoid dermatoses are discussed. Some of these lesions such as rheumatoid nodules are very common and some others are very rare.
MS Hosseini; AH Ehsani; S Toosi; R Mahmoud Robati
Volume 8, Issue 5 , 2005, , Pages 394-407
H Ansarin; F Shafi Khani; A Taher Pour
Volume 8, Issue 6 , 2006, , Pages 501-505
Abstract
Background and aim: Atopic dermatitis (AD) is a chronic relapsing skin disease that commonly begins during infancy and early childhood. Research studies refers to a relationship between exacerbation of atopic dermatitis and exposure to house dust mite (HDM), but the role of HDM in the pathogenesis of ...
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Background and aim: Atopic dermatitis (AD) is a chronic relapsing skin disease that commonly begins during infancy and early childhood. Research studies refers to a relationship between exacerbation of atopic dermatitis and exposure to house dust mite (HDM), but the role of HDM in the pathogenesis of AD is controversial. The objecitve of this study was to assess the correlation of density of HDM in homes of AD patients with clinical severity of AD and total serum IgE level.Materials and Methods: The severity of AD was determined in 150 patients referred to Hazrat-E-Rasoul hospital dermatology clinic from May 2001 to February 2003 using SCORAD. Total serum IgE level and mite population densities in 5 minutes suction of floors and mattresses at the homes of patients were determined.Results: There was an statistical correlation between relative mite population densities and total serum IgE with SCORAD (P=0.01).Conclusion: Reducing HDM population in homes of AD patient may help a better management of the patients.
Pouran Layegh; Parisa Emamgholitabar Malekshah; Seyyed Reza Mousavi
Volume 9, suppl.1 , 2006, , Pages 11-11
Abstract
Goltz syndrome / Focal Dermal Hypoplasia (FDH) is a rare syndrome resulting from developmental defects in tissues with mesodermal origin such as eye, skin, mouth, muscoloskeletal, and central nervous system. We report a 13-year-old girl with FDH who had several features of skin, eye, and mouth involvement. ...
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Goltz syndrome / Focal Dermal Hypoplasia (FDH) is a rare syndrome resulting from developmental defects in tissues with mesodermal origin such as eye, skin, mouth, muscoloskeletal, and central nervous system. We report a 13-year-old girl with FDH who had several features of skin, eye, and mouth involvement. She also had revurrent otitis media, which has not been reported so far.
Hayedeh Ghaninejad; Fatemeh Moeineddin; Ahmadreza Rajaee; Ahmad Salimzadeh; Masoud Asgari
Volume 10, Suppl.2 , 2007, , Pages 11-11
Abstract
Recently multiple cutaneous leiomyomas, uterine leiomyoimatosis and renal cancer have been described as a cancer syndrome with autosomal dominant pattern of inheritance.We report a 79-year-old man who presented with multiple hyperkertotic erythematous nodules on his right leg with histological diagnosis ...
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Recently multiple cutaneous leiomyomas, uterine leiomyoimatosis and renal cancer have been described as a cancer syndrome with autosomal dominant pattern of inheritance.We report a 79-year-old man who presented with multiple hyperkertotic erythematous nodules on his right leg with histological diagnosis of pilar leiomyoma. In his past medical history several systemic complaints such as gross hematuria, weight loss and bone pain were noted and further investigation confirmed histological diagnosis of metastatic papillary renal cell carcinoma. History of uterine leiomyomas and hysterectomy was peresent in his sister.All these findings in this case can be attributed to hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC Syndrome).
Shamshiri Hami
Volume 12, Issue 1 , 2009, , Pages 35-35
Abstract
A 40-year-old man was visited at our clinic with a history of pruritic cutaneous papules in a zosteriform pattern from 3 months ago. The skin lesions were located unilaterally on the right side of his thorax. On examination, there were multiple shiny, erythematous, violaceous and slightly scaly papules ...
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A 40-year-old man was visited at our clinic with a history of pruritic cutaneous papules in a zosteriform pattern from 3 months ago. The skin lesions were located unilaterally on the right side of his thorax. On examination, there were multiple shiny, erythematous, violaceous and slightly scaly papules limited to right T7 dermatome (Figure.1). General physical examination was unremarkable and mucous membranes were intact. A biopsy was taken and the specimen exhibited hyperkeratosis, focal increases in the granular cell layer, and irregular acanthosis with a saw tooth appearance, liquefactive degeneration of the basal cell layer and a band-like lymphocytic infiltrate at the dermo-epidermal junction and a number of Civatte bodies. He was treated with potent topical steroids. After 2 months, he came back with generalized lesions and typical mucosal lesions. This time, he was treated with systemic steroids. After 2 months, pruritus subsided and post inflammatory hyperpigmentation was formed, but mucosal lesions persisted. Lichen planus (LP) is an idiopathic inflammatory disease of the skin and mucous membrane. It is characterized by pruritic violaceous papules that favor the extremities1. Linear LP refers to LP with a unilateral linear distribution. This variant may present as an example of the Wolf’s isotopic response on the site of healed zoster2. In very rare instances, linear LP presents in a segmental fashion corresponding to one dermatome and is termed zosteriform LP. In extremely rare cases, zosteriform or linear distributions appear de novo on previously normal, non-traumatized skin, as in our patient. Although case reports of de novo dermatomal LP have been reported3, this entity is controversial. Happle argued that the term zosteriform lichen planus has been applied inappropriately in cases who have developed lesions de novo in the lines of Blaschko, rather than in true dermatomes4. Some authors believe that true zosteriform LP only exists in cases who have developed lesions on the sites of healed herpes zoster. In our patient, the distribution of lesions was limited to T7 dermatome. The patient denied prior history of herpes zoster. The linear eruption seemed to follow a true dermatome rather than in the Sshape pattern of the lines of Blaschko on the trunk. Although it is difficult to differentiate the two, these atypical distribution patterns may provide clues to the pathogenesis of a condition with a currently unknown etiology.
Amir Houshang Ehsani; Pedram Normohammadpour; Shahrbanoo Kheirkhah Sabetghadam
Volume 14, Issue 1 , 2011, , Pages 40-41
R Strohol; G Stingl
Volume 1, Issue 2 , 1998, , Pages 40-40
Mohammad Javad Nazemi Tabrizi; Reza Mahmoud Robati; Saeed Amini; Nima Sarrafi-Rad
Volume 11, Issue 1 , 2008, , Pages 44-45
Abstract
A one-year-old otherwise healthy girl presented with a progressively enlarging patch on the lateral aspect of her right ankle. Her parents stated that the lesion was not remarkable at birth but became more apparent with aging. There was no history of trauma or bleeding and family history for similar ...
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A one-year-old otherwise healthy girl presented with a progressively enlarging patch on the lateral aspect of her right ankle. Her parents stated that the lesion was not remarkable at birth but became more apparent with aging. There was no history of trauma or bleeding and family history for similar lesions was unremarkable. Physical examination showed an erythematous patch of superficial telangiectases in a linear distribution with a nevoid pattern on her right foot (figure 1). Other parts of the lower limb and general examination were unremarkable.
S Aslan Abadi; H Herizchi Ghadim
Volume 8, suppl , 2005, , Pages 45-48
Abstract
Epidermolysis bullosa are a group of hereditary skin diseases manifested as blisters on the sites of trauma to the skin. According to the level of blister development, epidermolysis bullosa are divided into the following groups: epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic ...
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Epidermolysis bullosa are a group of hereditary skin diseases manifested as blisters on the sites of trauma to the skin. According to the level of blister development, epidermolysis bullosa are divided into the following groups: epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic epidermolysis bullosa. The latter two groups are associated with poorer prognosis and higher mortality and morbidity in comparison with the first group due to the mucosal involvement and associated anomalies in other organs. The presented case was a neonate whom was presented with several blisters and erosions on skin since birth as well as clinical findings suggesting stomach outlet obstruction. It is important to evaluate neonates with epidermolysis bullosa for presence of probable associated anomalies.
H Poor Moghim; M Rezaei Salim
Volume 8, suppl , 2004, , Pages 53-58
Abstract
Allergic granulomatous angiitis (Churg-Strauss syndrome) is a variant of systemic vasculitis characterized by pulmonary and systemic small vessel vasculitis, extra-vascular granulomas and eosinophilia. Clinical features include presence of asthma and/or allergic rhinitis with constitutional symptoms ...
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Allergic granulomatous angiitis (Churg-Strauss syndrome) is a variant of systemic vasculitis characterized by pulmonary and systemic small vessel vasculitis, extra-vascular granulomas and eosinophilia. Clinical features include presence of asthma and/or allergic rhinitis with constitutional symptoms such as fever and weight loss. Multisystem involvement includes pulmonary infiltrations, monoeuritis multiplex, purpura and cutaneous nodules. Churg-Strauss syndrome is an uncommon condition, occur even more rarely in association with pregnancy and usually have a poor prognosis with increased risk of fetal death. In this article a 23-year-old patients who had developed signs and symptoms of the disease during pregnancy is reported. The full-flown picture of disease was revealed in peripartum period.
N Farsi; AR Firooz; M Rashighi Firoozabadi
Volume 8, Issue 1 , 2004, , Pages 66-69
Abstract
Pigmented Bowens disease is an in situ squamous cell carcinoma, which is seldom reported in white patients. Herein we report a 20-year-old woman with type III skin, who had this lesion on the fourth finger of her right hand, similar to superficial malignant melanoma, clinically. Although dermoscopic ...
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Pigmented Bowens disease is an in situ squamous cell carcinoma, which is seldom reported in white patients. Herein we report a 20-year-old woman with type III skin, who had this lesion on the fourth finger of her right hand, similar to superficial malignant melanoma, clinically. Although dermoscopic evaluation could be helpful, correct diagnosis of non-melanotic origin is done by histological examination. In spite of its rarity, pigmented Bowens disease should be considered in the differential diagnosis of malignant melanoma.
Z Haj Heidari; RA Mohammad Pour; Y Mohammadi Chelmardi
Volume 9, Issue 1 , 2006, , Pages 66-70
Sanjeev Gupta; Ajinkya Gujrathi; Aastha Sharma; sunita Gupta
Abstract
The COVID-19 pandemic has made it difficult for outpatient departments and hospitals to function normally. This has caused many patients to suffer due to a lack of regular follow-ups, with the unchecked progression of their disease further adding to their morbidity. With the advent ...
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The COVID-19 pandemic has made it difficult for outpatient departments and hospitals to function normally. This has caused many patients to suffer due to a lack of regular follow-ups, with the unchecked progression of their disease further adding to their morbidity. With the advent of technology, many centers have adopted the practice of teledermatology, which has allowednormal healthcare services to function to a certain extent. However, physical outpatient (private and institutional) clinics have also recently started accepting patients. Precautions like social distancing and sanitization have already been advised by various healthcare bodies but there are a few more general and specific (dermatologic) precautions for patients, staff and physicians that must be highlighted. As we move ahead navigating through these difficult times we must learn to adapt to the rapidly changing conditions and work toward establishing a safe environment for both patients and healthcare professionals.
Viroj Wiwanitkit
Volume 12, Issue 2 , 2009, , Pages 73-73
Abstract
Dermatological manifestations can be seen in many infectious diseases which can serve as diagnostic clues for such disorders. In dermatology, studying the dermatological manifestations of new emerging infectious diseases can be useful in clinical practice. For example, studying the dermatological manifestations ...
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Dermatological manifestations can be seen in many infectious diseases which can serve as diagnostic clues for such disorders. In dermatology, studying the dermatological manifestations of new emerging infectious diseases can be useful in clinical practice. For example, studying the dermatological manifestations of human immunodeficiency virus infection (HIV) in its early emerging period yielded several useful clinical data that is still helpful in cases infected with HIV. Bird flu (H5N1 influenza virus infection) is a new emerging infectious disease. It has recently been documented in medical literature for only a few years. Our knowledge on the dermatological manifestations of the bird flu is limited. It is an interesting topic to assess and summarize data regarding the dermatological manifestations of the bird flu. The author hereby performed a retrospective study to answer this research question. This brief study was a retrospective research which was done through review of the available literature. In this study, the author reviewed reports concerning human bird flu infection from Thailand available in Index Medicus and Science Citation Index. The author also reviewed published papers in all 256 local Thai journals which are not indexed in international databases. The reports that contained incomplete data were excluded for further analysis. The focus of attention in each paper was the reported dermatological manifestations due to the bird flu infection. Summarization of all determined findings was performed using the basic descriptive statistical analysis. According to this retrospective study, there were 6 included reports on 12 indexed cases1,5. Based to the literature, there was no dermatological manifestation in the reported cases of human H5N1 infection. The prevalence rate of dermatological manifestations in the bird flu infected cases in this study was equal to 0 %. Naturally, H5N1 virus is a kind of influenza virus. In dermatology, human influenza virus may have some dermatological manifestations6. However, the author found no report or evidence regarding the dermatological manifestations of bird flu in reviewed cases. This might imply that dermatological manifestations are not of clinical importance in bird flu based on case series from Thailand. Finally, the author proposes that there might be no dermatological manifestation in human H5N1 infection.
Farhad Malekzad; Behrooz Barikbin; Zahra Ghoorchiani
Volume 10, Issue 1 , 2007, , Pages 78-82
Abstract
Perforating granuloma annulare (PGA) is a rare subtype of GA. It is characterized by crops of erythematous umblicated or scaly papules. Plaques, pustule-like lesions and scars may also be seen. It can be localized or generalized.Transepithelial elimination of mucinous, degenerating collagen fibers and ...
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Perforating granuloma annulare (PGA) is a rare subtype of GA. It is characterized by crops of erythematous umblicated or scaly papules. Plaques, pustule-like lesions and scars may also be seen. It can be localized or generalized.Transepithelial elimination of mucinous, degenerating collagen fibers and surrounding palisading lymphohistiocytic granulomas, are important histologic features.The patient reported here was a 23-year-old man with recurrent crops (every few weeks) of umbilicated papular lesions predominantly affecting trunk and extremities for 8 years, which resolved with varioliform scars.
Wiwanitkit Viroj
Volume 14, Issue 3 , 2011, , Pages 121-121
Neda Hosseini Sarani; Mehran Ataei; Tannaz Akbari Kolagar; Elaheh Heydari; Maryam Farzaneh; Amir Anbiyaiee
Abstract
Skin cancer is the out-of-control growth of skin cells that can be divided into keratinocyte carcinoma (non-melanoma) and malignant melanoma. Basal cell carcinoma (BCC) and squamous cell carcinomas (SCC) are the most common forms of keratinocyte carcinoma that may grow to involve other parts of the body. ...
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Skin cancer is the out-of-control growth of skin cells that can be divided into keratinocyte carcinoma (non-melanoma) and malignant melanoma. Basal cell carcinoma (BCC) and squamous cell carcinomas (SCC) are the most common forms of keratinocyte carcinoma that may grow to involve other parts of the body. These cancers are caused by exposure to ultraviolet (UV) light, toxic substances, and a family history of skin problems. Different signaling pathways are likely to be involved in skin cancer. The TP53 gene (the gene coding for cellular tumor protein p53) is among the most diverse and complex molecules involved in cellular functions. The p53 pathway can initiate DNA replication, modulate cell cycle events, and interact with tumor suppressor genes (TSGs). Mutations in TP53 can occur in numerous human cancers, leading to cellular immortalization, inappropriate proliferation, and genomic instability. TP53 plays a big role in both melanoma and non-melanoma skin cancers. Despite the intensive investigation to clarify the impact of TP53 mutations in the induction of skin cancer, much remains to be elucidated. In this mini-review, we will discuss the protective role of p53 as a bona fide tumor suppressor gene in human skin cancers.
J Golchai; O Zargari; A Sayyadi Nejad; A Maboudi; S Geranmayeh
Volume 8, Issue 2 , 2005, , Pages 140-144
Abstract
Pseudoporphyria is an uncommon bullous disease with similar clinical and histopathological findings to porphyria cutanea tarda, in the absence of detectable porphyrin elevation. We present a 34-year-old man with clinical and histological findings compatible with porphyria cutanea tarda, whose his urinary ...
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Pseudoporphyria is an uncommon bullous disease with similar clinical and histopathological findings to porphyria cutanea tarda, in the absence of detectable porphyrin elevation. We present a 34-year-old man with clinical and histological findings compatible with porphyria cutanea tarda, whose his urinary uroporphyrin was negative and we concluded that he was a case of pseudoporphyria. Concomitant active infection with hepatitis C virus was a unique finding in this patient.
S Shamsedini; S Rajab Alian; M Mirzaei; M Brofei
Volume 9, Issue 2 , 2006, , Pages 173-178
Abstract
Background and aim: Leishmaniasis is a zoonotic disease with wide clinical diversity caused by protozoan parasite belonging to the genus of Leishmania. Treatment of human leishmaniases are still based on pentavalent antimonials but their toxicity and emerging resistance are problematic. This study was ...
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Background and aim: Leishmaniasis is a zoonotic disease with wide clinical diversity caused by protozoan parasite belonging to the genus of Leishmania. Treatment of human leishmaniases are still based on pentavalent antimonials but their toxicity and emerging resistance are problematic. This study was performed to assess the effect of Mimosa tenuiflora extract on L. tropica promastigotes to find potential new therapeutic method against leishmaniasis.Materials and Methods: This study has been based on two in vitro methods: methyl thiazole tetrazolium (MTT) assay and counting parasites, using 10, 100, 500, 1000 micg/ml concentrations of plant extract.Results: Different concentrations of M. Tenuiflora extract have different effects on multiplication of Leishmania protozoa in culture medium. Concentration of 1000 and 500 micg/ml suppressed multiplication of promastigotes but at a concentration of 100 micg/ml it accelerated growth of promastigotes.Conclusion: This finding suggested that M. tenuiflora extract contains both inhibitory and acceleratory effects on Leishmania growth in vitro.
