Document Type : Original Article
Authors
- Alireza Ghanadan 1
- Kambiz Kamyab 2
- Ali Nili 3
- Hamidreza Mahmoudi 3
- Vahidehsadat Azhari 4
- Anahita Borzouei 4
- Shirin Taraz Jamshidi 5
1 Department of Dermatopathology, Razi Hospital, and Pathology Department of Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Dermatopathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3 Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
4 Dermatopathology Department, Razi Skin Hospital, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.
Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic and clinical data were entered into a checklist. The pathology slides were reviewed to confirm the diagnosis. The demographic profile of all patients, including age and gender, primary clinical impression, multiplicity of the tumor, microscopic features, and location of tumoral involvement, were extracted. Qualitative data were summarized using frequencies and percentages. Regarding descriptive analysis, the frequency of each histopathologic feature was calculated.
Results: Two groups of patients were identified regarding age. This tumor was more common in males among adult patients, while a female preponderance was seen in those under 18. Most lesions were located on the face (40%), followed by upper (32%) and lower (10%) limbs. In addition to well-known histological features, we observed intraepidermal pilomatricoma in two cases presenting unique histopathologic features. Both showed foci of suprabasal cleft formation, while one showed the Borst-Jadassohn phenomenon. These features, in addition to sebaceous differentiation and acantholysis of ghost cells, were not addressed in previous literature.
Conclusion: Understanding the diverse and new histological features of pilomatricoma is necessary for differentiating it from other adnexal and soft tissue tumors.
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