Rohit Singla; Kritika Singla; Saurabh Swaroop Gupta; Sanjeev Gupta; Aneet Mahendra; Akriti Gakhar
Abstract
Background: Multiple studies indicate the correlation between lichen planus (LP) and certain systemic disorders. Data suggest an increased incidence of dyslipidemia with LP. Abnormal lipid levels are major risk factors for developing atherosclerotic changes and cardiovascular disorders (CVD). Non-high-density ...
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Background: Multiple studies indicate the correlation between lichen planus (LP) and certain systemic disorders. Data suggest an increased incidence of dyslipidemia with LP. Abnormal lipid levels are major risk factors for developing atherosclerotic changes and cardiovascular disorders (CVD). Non-high-density lipoprotein cholesterol (non-HDL-C) is a reliable marker for cardiovascular events. If non-HDL-C levels are raised in LP patients, it would mean that these individuals are high-risk patients and should be investigated periodically. We aimed to find non-HDL-C serum levels in cases of lichen planus and compare them with controls.Methods: We compared lipid profiles between 100 cases of LP and 50 healthy controls.Results: Non-HDL-C levels were significantly higher in cases than controls (P = 0.002). The non-HDL-C level was elevated in 67% of LP cases, compared to 42% of controls.Conclusions: We demonstrated higher levels of non-HDL-C in LP patients than in controls, confirming the increased risk of CVDs in LP patients.
Saurabh Swaroop Gupta; Aneet Mahendra; Sanjeev Gupta; Rohit Singla
Abstract
Background and Aim: Alopecia areata (AA) is a chronic, autoimmune disease that causes non-scarring hair loss. Recently, serum vitamin D has been implicated in the etiopathogenesis of AA due to its immunoregulatory effects. Its deficiency can cause a loss of selftolerance and predispose individuals to ...
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Background and Aim: Alopecia areata (AA) is a chronic, autoimmune disease that causes non-scarring hair loss. Recently, serum vitamin D has been implicated in the etiopathogenesis of AA due to its immunoregulatory effects. Its deficiency can cause a loss of selftolerance and predispose individuals to autoimmune diseases. This study compared the serum vitamin D levels between AA cases and controls. We aimed to compare the serum levels of vitamin D between AA patients and age and sex-matched healthy controls and to elucidate any correlation between AA and vitamin D serum levels in terms of disease pattern, severity, and extent.Methods: A case group comprising 25 AA patients and a second group of 25 healthy controls of 10 years of age or older were involved in the study. A detailed history was taken, along with a complete clinical examination. Serum vitamin D levels were measured and compared between the groups.Results: The mean level of vitamin D in cases (17.15 ± 5.01 ng/ ml) was significantly lower as compared to controls (34.58 ± 20.83 ng/ml) (P < 0.001). The duration, pattern, and severity of AA had no significant relationship with patients’ serum vitamin D levels.Conclusion: We demonstrated a statistically significant variation in serum vitamin D between controls and cases, with lower values in patients. Our findings indicate a possible cause-and-effect relationship between low serum vitamin D and AA, which needs further exploration.
