Arunima Dhabal; Jayanta Kumar Barua; Kingshuk Chatterjee; Ananya Chandra; Sumana Khan; Manab Kumar Ghosh; Saswati Halder
Abstract
Background: Lichen planus (LP) is a chronic inflammatorydisorder involving the skin, mucosa, hair, and nails. Previousreports have shown a possible association between LP andmetabolic derangement, leading to increased cardiovascular riskamong these patients. Our study aimed to assess the prevalenceof ...
Read More
Background: Lichen planus (LP) is a chronic inflammatorydisorder involving the skin, mucosa, hair, and nails. Previousreports have shown a possible association between LP andmetabolic derangement, leading to increased cardiovascular riskamong these patients. Our study aimed to assess the prevalenceof metabolic syndrome (MetS) and its components in LP patientsand to study their relationship with mucosal involvement in LP.Methods: We conducted a cross-sectional observational study of123 LP patients. Demographic and clinical data were obtained,and evaluation was done for the presence of abdominal obesity,hypertension, hyperglycemia, and dyslipidemia. MetS wasdiagnosed according to the modified National CholesterolEducation Program: Adult Treatment Panel III (NCEP-ATP III)criteria for the South Asian population. Data analysis was doneusing appropriate statistical methods.Results: The prevalence of MetS in LP patients was 31%. The meanage of LP patients having MetS was considerably higher thanthose without MetS (44.8 ± 13.6 vs. 33.3 ± 15.9 years; P = 0.0002).Although statistically insignificant, female patients and patients withmucosal involvement showed a higher prevalence of MetS. Centralobesity, hypertension, hyperglycemia, and hypertriglyceridemiawere more prevalent in mucosal LP patients than in those withoutmucosal lesions, with hyperglycemia having a significantly higherprevalence in mucosal LP (41% vs. 18%; P = 0.015).Conclusion: Incre ased age, female gender, and mucosalinvolvement are important predictors of concurrent metabolicderangement in LP patients. Thus, these patients should bescreened for the presence of MetS and its components.
Arun Achar; Lokhnath Ghoshal; Smriti Chowdhury; Samiran Bisai
Abstract
Background: Palmoplantar psoriasis (PPP) and hyperkeratotic eczema (HPKE) are common and troublesome entities affecting the palms and soles. The diagnosis is made clinically, but differentiation is difficult; histopathology helps but is often impossible in daily practice. Dermoscopy is increasingly utilized ...
Read More
Background: Palmoplantar psoriasis (PPP) and hyperkeratotic eczema (HPKE) are common and troublesome entities affecting the palms and soles. The diagnosis is made clinically, but differentiation is difficult; histopathology helps but is often impossible in daily practice. Dermoscopy is increasingly utilized to diagnose inflammatory disorders and has been used to differentiate PPP from HPKE. The present study was carried out to evaluate the role of dermoscopy in the differentiation of PPP and HPKE in a tertiary care center of eastern India.Methods: This hospital-based observational study included 20 patients with each of clinically diagnosed PPP and HPKE. Dermoscopy examinations were done, and the results were tabulated and summarized. Fisher’s exact test was employed to assess statistical significances in differences.Results: Diffuse white and yellow scales were found in both PPP and HPKE without any significant difference. Brown orange globules, clustered dotted vessels, yellow, orange crusts, and perilesional scaling were found more in HPKE (P < 0.05). On the other hand, uniformly dotted vessels and background erythema were more characteristic of PPP (P < 0.05). The results of the current study had deviations from the results of studies done abroad, which can be ascribed to differences in skin color.Conclusion: Dermoscopy is a valuable tool to sort out diagnostic dilemmas in cases of PPP and HPKE. It should be used more commonly to gain more experience and information in the diagnosis of inflammatory dermatoses.