Ebrahim Esmati; Mojtaba Vand Rajabpour; Mohammad Shirkhoda; Vahid Soleimani; Maryam Garousi
Abstract
Trichilemmal carcinoma is a rare tumor of the outer sheath cells of hair follicles. These tumors occur on the sun-exposed skin of the elderly in the majority of cases. The gross tumor demonstrates exophytic, polypoid, ulcerative, or nodular lesions with or without bleeding. Histopathologically, it is ...
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Trichilemmal carcinoma is a rare tumor of the outer sheath cells of hair follicles. These tumors occur on the sun-exposed skin of the elderly in the majority of cases. The gross tumor demonstrates exophytic, polypoid, ulcerative, or nodular lesions with or without bleeding. Histopathologically, it is characterized by an anastomosing trabecular, diffuse, or lobular growth pattern with clear keratinization. A critical differential diagnosis is squamous cell carcinoma (SCC), where the prognosis of trichilemmal carcinoma is far better than SCC. Surgery is a significant and effective treatment for trichilemmal carcinoma cases, and recurrence after complete surgical resection with a negative margin is uncommon. Trichilemmal carcinoma is considered a low-grade tumor with low metastatic potential. This paper reports a 48-year-old Iranian male with trichilemmal carcinoma of the scalp treated with surgery, having no recurrence after three years of follow-up. The role of other treatment modalities like radiation, local therapy, and systemic therapy are also discussed.
Kafaie Parichehr; Akaberi Ali Akbar; Hajihoseini Hosein; Binesh Fariba
Volume 12, Issue 2 , 2009, , Pages 69-70
Abstract
Acne keloidalis is a chronic inflammatory process that involves hair follicles of the nape of the neck and leads to hypertrophic scarring. In all references, it is noticed that this process occurs only in males after puberty and is especially seen in the black race. In this case, we report a 31-year-old ...
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Acne keloidalis is a chronic inflammatory process that involves hair follicles of the nape of the neck and leads to hypertrophic scarring. In all references, it is noticed that this process occurs only in males after puberty and is especially seen in the black race. In this case, we report a 31-year-old white woman who had hypertrophic papules in the nape of her neck since 10 years ago and in pathological examination, the diagnosis of acne keloidalis was confirmed.
Khooei Alireza; Farhadi Farzaneh
Volume 10, Issue 4 , 2007, , Pages 262-270
Abstract
Background and aim: The skin has some appendages that give origin to various tumors. These tumors are generally divided to pilosebaceous and sweat glands tumors according to embryologic and histological features. Clinical and histological characteristics of these tumors are also divergent. In addition, ...
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Background and aim: The skin has some appendages that give origin to various tumors. These tumors are generally divided to pilosebaceous and sweat glands tumors according to embryologic and histological features. Clinical and histological characteristics of these tumors are also divergent. In addition, classification of them according to histological background has been changed considerably in recent years. The aim of this study is to asses the frequency and clinicoepidemiologic characteristics of these tumors based on re-evaluation of the tissue specimens by applying new histological criteria for a better understanding, experience and reclassification. Materials and methods: All tissue samples with a definite, differential, probable or uncertain diagnosis of any kind of skin appendage tumors, archived in Pathology Department of Imam Reza University Hospital of Mashhad, during the past 30 years (1976-2005) were elicited. All the specimens were reobserved histopathologically by applying new diagnostic criteria and if necessary, were recut and stained with H&E and special histochemical stains. Clinical data were gathered and presented in tables and charts and analyzed statistically by SPSS software. Results: From 134748 archived specimens, 444 appendageal tumors were found of which 161 were of follicular origin composed of 119 pilomatrixoma (73.9%), 19 trichoepithelioma (11.8%), 15 inverted follicular keratoses (9.3%), 4 proliferating pilar tumor (2.5%), 2 trichoblastoma (1.2%), 1 trichofolliculoma (0.6%) and 1 trichoadenoma (0.6%), with a mean age of 28 years in 71 men and 90 women. The most prevalent location was head and neck area (57.5%) and the most common presentation was a nodule (81%), mostly single (94%). In most cases previous pathologic diagnosis was confirmed (95.2%) and clinico-epidemiologic features were in accordance with other world wide reports, although some changes in tissue diagnosis and differences in clinico-epidemiologic features were noted. Conclusion: Hair follicular tumors are relatively uncommon tumors, mostly benign and occurring in youngs specially in head and neck. Some differences in clinico-epidemiologic features could be related to race, genetic background, environment and etc. Some mistakes in previous tissue diagnosis alarm the pathologist to pay special attention to the wide range of differential diagnosis and to employ definite histopathologic criteria regarding differences in patterns of involvement.
