Dadras Mohammad Shahidi; Golfeshan Atefe; Younespour Shima
Volume 18, Issue 2 , 2015, , Pages 51-55
Abstract
Background: It seems that there are similar associated diseases in psoriasis and Lewis (b) negative phenotypes such as diabetesmellitus, cardiovascular events, and metabolic syndrome. Therefore, we decided to evaluate the frequency of Lewis henotypes in patients with chronic plaque type psoriasis. A ...
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Background: It seems that there are similar associated diseases in psoriasis and Lewis (b) negative phenotypes such as diabetesmellitus, cardiovascular events, and metabolic syndrome. Therefore, we decided to evaluate the frequency of Lewis henotypes in patients with chronic plaque type psoriasis. A limited number of studies have been previously conducted in this regard.Methods: Fifty patients and 100 age and gender matched control subjects were selected as the study population. Two milliliter of venous blood was collected from each subject to find out the Lewis phenotype and in subjects with the Le (a-b-) henotype, saliva was collected to determine the secretory status. All individuals with the Le (a-b-) phenotype were typed as non-secretor in their saliva by the hemagglutination inhibition assay; therefore, in this study, Lewis (b) positive individuals were considered as secretor and Lewis (b) negative as non-secretor phenotypes.Results: There was a significant difference in the secretory status or Lewis phenotypes between the two groups. ABH on-secretory status Le (a-b-) and Le (a+b-) together or Lewis b negative phenotypes were found in 78% (39 of 50) of the patients and 26% (26 out of 100) of the healthy controls (P
Ghandi Narges; Daklan Soroush; Goodarzi Azadeh; Hesari Kambiz Kamyab; Ghanadan Alireza
Volume 18, Issue 1 , 2015, , Pages 33-35
Abstract
The histiocytoses are a group of proliferative disorders of themonocyte-macrophage lineage that are neoplastic or reactive innature. Based on immunophenotyping and electron microscopy,two main groups have been recognized namely 1) Langerhanscell histiocytosis (LCH) and 2) non- Langerhans cell histiocytosis(non-LCH). ...
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The histiocytoses are a group of proliferative disorders of themonocyte-macrophage lineage that are neoplastic or reactive innature. Based on immunophenotyping and electron microscopy,two main groups have been recognized namely 1) Langerhanscell histiocytosis (LCH) and 2) non- Langerhans cell histiocytosis(non-LCH). In this study, a fairly rare disease of the non-LCHgroup, generalized eruptive histiocytosis, has been reported.
Anvari Kazem; Hosseini Sare; Toussi Mehdi Seilanian; Afifi Saeede
Volume 17, Issue 1 , 2014, , Pages 27-30
Abstract
Background: Non melanoma skin cancer (NMSC) is the most common cancer worldwide. In most cases, the general outlook is excellent; however, local recurrence or metastasis can occur. In this study, we investigated possible tumor and host characteristics affecting the treatment outcome in our department ...
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Background: Non melanoma skin cancer (NMSC) is the most common cancer worldwide. In most cases, the general outlook is excellent; however, local recurrence or metastasis can occur. In this study, we investigated possible tumor and host characteristics affecting the treatment outcome in our department of radiation oncology.Method: We retrospectively studied cases with non melanoma skin cancer (NMSC) who were consecutively referred to department of radiation oncology in Omid and Ghaem Hospitals between 1997 and 2007. The effect of the patients’ characteristics (age, sex), tumor characteristics (histology, size, location), and treatment modalities on prognosis were evaluated.Result: We studies 426 patients with a median age of 65 (range: 14 to 102) and a male to female ratio of 1.4:1. Pathologic review showed 72% of the patients had basal cell carcinoma (BCC) and 28% had squamous cell carcinoma (SCC) with a 5-year event free survival of 87±3% and 67±8%, respectively (p < 0.001). The local recurrence rate was higher in cases with scalp lesions (35%). The patients who underwent combined modality treatment experienced significantly more instances of failure as compared to those receiving radiotherapy alone (5-year event free survival of 81±6% vs. 84±6%, p=0.04) which reflects the higher number of cases with adverse features including larger lesions and/or a positive surgical margin in this group. Sex, age, and multifocality were not significant predictors of prognosis.Conclusion: SCC histology and scalp location were predictive of higher rates of treatment failure in patients with NMSC. There was no correlation between age, sex, multifocality and overall outcome. The higher rate of recurrence in cases receiving combined modality treatment is most probably due to the high number of tumors with adverse prognostic features in these cases.
N Darvishi Zadeh
Volume 3, Issue 2 , 2000, , Pages 16-22
Abstract
Background: Non-melanocytic skin cancers (NMSC) including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are mostly induced by long life sun ultraviolet radiation (UVR). Although many etiological factors are known in skin cancer, the role of sunlight is the most prominent. Khuzestan is ...
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Background: Non-melanocytic skin cancers (NMSC) including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are mostly induced by long life sun ultraviolet radiation (UVR). Although many etiological factors are known in skin cancer, the role of sunlight is the most prominent. Khuzestan is one of the southern provinces of Iran, which has sunny sky and long summer. So it is presumed that skin cancers are common in Khuzestan. Objective: To study non-melanocytic skin cancers in Ahwaz. Patients and Methods: In this retrospective study, pathological diagnosis of NMSC in an educational hospital of the province has been analyzed. Results: During years 1994-1998, total of 636 patients have been diagnosed, 40% female and 60% male. 83% of female patients had BCC and 17% had SCC. 71.5% of male patients had BCC and 26.5% had SCC. BCC to SCC ratio in male and female patients were 2.7 and 5 respectively, and 3.4 in whole. In both sexes the most common age of the diagnosis was the seventh decade. Most of the patients had outdoor occupations. Conclusion: The results of this study indicate that NMSC is more common in male who have outdoor occupations and proper education and protective measures for individuals at high risk must be considered.