Dastgheib Ladan; Saki Nasrin; Heiran Alireza; Kardeh Bahareh; Saki Mohammad Reza
Volume 20, Issue 3 , 2017, , Pages 79-83
Abstract
Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. ...
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Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. The aimof this study is to assess the prevalence of certain autoimmune diseases in first degree relatives of patients with psoriasis compared with a control group. Methods: In this cross-sectional study we used a questionnaire to compare the frequency of type 1 diabetes, autoimmune thyroid disease, vitiligo, lupus erythematosus, multiple sclerosis, ulcerative colitis, Crohn’s disease, and rheumatoid arthritis in first degree relatives of 109 pathologically confirmed psoriasiscases with the first degree relatives of 109 age-sex matched controls. R programming language (version 3.3.1 for Windows) and the rattle graphical user interface (GUI) package were applied for statistical analysis. A P-value?0.05 was considered to be statistically significant. Results: We compared 955 first degree relatives of psoriatic patients with 934 family members of the controls. There was significantly greater total autoimmune diseases [odds ratio (OR): 2.74, 95% confidence interval (CI): 1.95-3.87, P<0.001), particularly psoriasis (OR: 38.66, 95% CI: 5.3-282.19, P<.0001), in first degree relatives of psoriatic patients compared to family members of the control group. Regardless of gender, autoimmune thyroid disease was more prevalent among first degree relatives of psoriatic patients (OR: 2.81, 95% CI: 1.36-5.83, P=.0066). No statistically significant difference was found regarding type 1 diabetes, rheumatoid arthritis, multiple sclerosis, vitiligo, Crohn’s disease, and ulcerative colitis. Conclusion: First degree relatives of patients with psoriasis had significantly higher autoimmune diseases. This finding was particularly noticed for psoriasis and autoimmune thyroid disease.
Mohammad Ali Mapar; Amir Hosein Roozbeh; Mohammad Bagher Mohammad Hasani
Volume 14, Issue 2 , 2011, , Pages 64-67
Abstract
Bachground: Erythroderma is a rare but serious skin disorder that may result from different causes. There are many publications on this subject, with a different incidence rate for each etiology. The aim of this study was to determine the frequency of erythroderma, and describe the incidence of each ...
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Bachground: Erythroderma is a rare but serious skin disorder that may result from different causes. There are many publications on this subject, with a different incidence rate for each etiology. The aim of this study was to determine the frequency of erythroderma, and describe the incidence of each etiologic cause in patients indigenous to Khuzestan. Methods: In a retrospective study, we reviewed the files of patients diagnosed with erythroderma who were admitted to the dermatology ward of Sina Hospital, affiliated to Jondishapour Medical University of Ahvaz, southwest of Iran, in a period of 9 years from 1980 to 1989. We studied the clinical and pathology reports of patients and the final etiologic diagnosis. Results: Total admission was 6210 patients and the total number of erythrodermic patients was 85. The frequency of erythroderma in our dermatology department was 1.37%. The most common causes in order of frequency were eczema (32.94%), drug reaction (23.52%), psoriasis (21/18%), and malignancy (8.23%). Previous history of skin disease was found in 44 of 85 patients (51.76%) and 28 (32.9%) of them were suffering from eczema. The mean age of our patients was 49.11 years and the male-female ratio was 1.6:1. Conclusion: Erythroderma is a rare condition. The most common causes in our study were eczema and drug reactions; the high incidence of drug reactions in our patients compared to studies in other countries may be due to more administration of drugs in Iran, especially in Khuzestan.
Moin Athar; Dowlati Yahya
Volume 9, Issue 4 , 2006, , Pages 343-349
Abstract
Background and aim: Skin diseases among pilgrims are considered to be one of the possible health problems. Data supporting this observation are scanty. The aim of this study was to report the most common skin diseases seen in Hajj season. Materials and Methods: Data regarding skin diseases were collected ...
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Background and aim: Skin diseases among pilgrims are considered to be one of the possible health problems. Data supporting this observation are scanty. The aim of this study was to report the most common skin diseases seen in Hajj season. Materials and Methods: Data regarding skin diseases were collected from piligrims whom were examined and diagnosed clinically at the skin clinics of Iran in Saudi Arabia in 1993 and 1999. Results: During the Hajj season in 1999, 362 patients were seen. The most common groups of diseases were eczemas of different types and related conditions (35.9%), mechanical and thermal injury (17.6%) and infections (16.5%), accounted for more than 70% of cases. During Hajj season in 1993, 560 patients were seen. The most common groups of diseases were infections (19.3%), eczema and related conditions (18.6%) and disorders of skin appendages (16.4%), accounted for about 54.2% of observed skin diseases.Conclusion: The finding of these most common skin disorders is important in training programmes and delivery of service for care of pilgrims, because they are preventable, easily diagnosed and curable in the majority of patients.
M Barzegari; Z Safaei Naraghi; M Akhyani; AH Ehsani; R Mahmoud Robati; S Bagheri Nejad
Volume 9, Issue 2 , 2006, , Pages 159-164
Abstract
Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency ...
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Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency of BCC in 1368-69 and 1378-79.Materials and Methods: This descriptive and retrospective study was performed as an existing data study and all files in department of pathology in Razi Hospital from 1368-69 and 1378-79 were assessed with regards of BCC frequency, patient age and gender as well as history of radiation and the collected data were compared.Results: A total of 1503 BCCs were studied, 507 were from 1368-69 and 996 from 1378-79 period. In the years 1368-69, relative frequency of BCC was 11.1%. On the other hand in years 1378-79 relative frequency of BCC was increased to 15.2%, which was not associated with gender. BCC occurance showed a significant decrease in 20-30-year age group and a significant increase in over 60 years age group. Among histologic subtypes, nodular form showed an increase, which was statistically significant on face region (P<0.005), but was not linked to patient gender. In male patients significant decrease of BCC frequency on face and increase on head and neck areas was observed, but there was not any significant change in tumor location in female patients.Conclusion:During a 10-year period the frequency of BCC has increased significantly requiring more attention to develop educational programs regarding prevention, diagnosis and early treatment.
M Danesh Pajouh; K Balighi; F Safar; M Asheghan; M Asadollahi; Gh.R Hassiri
Volume 8, Issue 4 , 2005, , Pages 272-275
Abstract
Background and objective: Psoriasis is chronic inflammatory skin disorder with a wide variety of clinical presentations. Presence of anti-gliadin antibody (AGA) has been reported in 16% of psoriatic patients. This study was designed to determine the frequency of the presence of AGA in psoriatic patients. ...
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Background and objective: Psoriasis is chronic inflammatory skin disorder with a wide variety of clinical presentations. Presence of anti-gliadin antibody (AGA) has been reported in 16% of psoriatic patients. This study was designed to determine the frequency of the presence of AGA in psoriatic patients. Materials and Methods: After recording the demographic data and the severity of disease according to PASI scoring system, serum of 10 psoriatic patients and 100 healthy controls were studied for the presence of AGA using indirect innumofluorescence method. Results: AGA was present in sera of 4 (3 males and one female) psoriatic patient while all controls were negative. Three patients were from 20 to 40 years of age. All four AGA positive patients suffered from plaque type psoriasis. The disease severity was mild in one, moderate in two, and severe in one patient. None of them suffered from gastrointestinal problems. Conclusion: Although AGA may be present in the serum of some psoriatic cases, a significant relation between skin lesion and hypersensivity to gluten has not been determined yet. More studies using more specific and sensitive assessment methods and larger sample sizes are suggested.
