Alireza Ghanadan; Kambiz Kamyab; Ali Nili; Hamidreza Mahmoudi; Vahidehsadat Azhari; Anahita Borzouei; Shirin Taraz Jamshidi
Abstract
Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic ...
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Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic and clinical data were entered into a checklist. The pathology slides were reviewed to confirm the diagnosis. The demographic profile of all patients, including age and gender, primary clinical impression, multiplicity of the tumor, microscopic features, and location of tumoral involvement, were extracted. Qualitative data were summarized using frequencies and percentages. Regarding descriptive analysis, the frequency of each histopathologic feature was calculated.Results: Two groups of patients were identified regarding age. This tumor was more common in males among adult patients, while a female preponderance was seen in those under 18. Most lesions were located on the face (40%), followed by upper (32%) and lower (10%) limbs. In addition to well-known histological features, we observed intraepidermal pilomatricoma in two cases presenting unique histopathologic features. Both showed foci of suprabasal cleft formation, while one showed the Borst-Jadassohn phenomenon. These features, in addition to sebaceous differentiation and acantholysis of ghost cells, were not addressed in previous literature.Conclusion: Understanding the diverse and new histological features of pilomatricoma is necessary for differentiating it from other adnexal and soft tissue tumors.
Anchitha H; Pramod Kumar; Deepti Dsouza; Pooja K Suresh
Abstract
Tufted angioma is an uncommon vascular benign tumor of infancy or early childhood with slow and indolent growth. We report the case of a four-year-old boy with an asymptomatic annular lesion over the nape of the neck resembling granuloma annulare. Punch biopsy revealed multiple scattered vascular lobules ...
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Tufted angioma is an uncommon vascular benign tumor of infancy or early childhood with slow and indolent growth. We report the case of a four-year-old boy with an asymptomatic annular lesion over the nape of the neck resembling granuloma annulare. Punch biopsy revealed multiple scattered vascular lobules or tufts. Aggregates of closely packed, dilated to compressed vascular spaces with plump endothelial cell lining were seen in the dermis, confirming the diagnosis of tufted angioma. Immunohistochemical positivity was present with CD31 and CD34 staining of endothelial cells. It is a slow-growing tumor; Kasabach–Merritt syndrome (KMS) and consumptive coagulopathy are rare complications. Blood coagulation profiles were within normal limits. In our case, the lack of reliable distinguishing characteristics of the vascular tumor and atypical annular presentation was a source of diagnostic confusion. Tenderness, typically present in tufted angiomas, was absent in our patient. This unusual case illustrates that clinicians should recognize an annular configuration as an atypical manifestation of tufted angioma.
Ravindranath Brahmadeo Chavan; Vasudha A Belgaumkar; Nitika Deshmukh; Balakrishna Nikam; Vijay Deepak Joshi
Abstract
Proliferating trichilemmal tumors are rare, generally solitary, benign tumors arising from the hair’s outer root sheath with trichilemmal keratinization. These tumors are predominantly found on the head, neck, and face of elderly females; the inguinal region is a highly unusual site of involvement. ...
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Proliferating trichilemmal tumors are rare, generally solitary, benign tumors arising from the hair’s outer root sheath with trichilemmal keratinization. These tumors are predominantly found on the head, neck, and face of elderly females; the inguinal region is a highly unusual site of involvement. Malignant change in this tumor is rare, histologically mimicking squamous cell carcinoma. Metastatic malignant proliferating trichilemmal tumor requires a high index of suspicion for diagnosis and accurate histopathological reporting for timely intervention. Here, we report the case of a 65-yearold man presenting with nodular-ulcerative lesions in the groin, clinically confused with hidradenitis suppurativa and histologically with squamous cell carcinoma. He was finally diagnosed with an inoperable metastatic stage of malignant proliferating trichilemmal tumor and was treated with palliative care. This case highlights the innocuous clinical appearance of such lesions that might delay the management of this fulminant tumor.
Narges Alizadeh; Javad Golchai; Atefeh Ghanbari; Behrooz Golchai; Shirin Zaresharifi
Abstract
Background: Anogenital warts are the most prevalent sexually transmitted disease worldwide and are caused by human papillomavirus (HPV). There are more than 100 different types of HPV, of which certain types make the patient more susceptible to malignant neoplasms. This study aimed to determine the frequencies ...
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Background: Anogenital warts are the most prevalent sexually transmitted disease worldwide and are caused by human papillomavirus (HPV). There are more than 100 different types of HPV, of which certain types make the patient more susceptible to malignant neoplasms. This study aimed to determine the frequencies of specific types of HPV in anogenital warts.
Methods: This study included 157 patients diagnosed with anogenital warts that underwent HPV DNA detection using polymerase chain reaction (PCR) with INNO-LiPA genotyping assay.
Results: Of 157 patients with anogenital warts, 122 samples (77.7%) were positive for HPV, with some patients showing mixed HPV subtypes. HPV 6 (n = 99; 68.3%) and HPV 11 (n = 13; 8.9%) were the most prevalent types. 101 patients were male (64.3%). The mean age was 32.02 ± 10.06 years (range: 2 to 72 years). Most patients were infected with the low-risk types (80%); the high-risk HPV type 16 was significantly more common among women (P = 0.0001).
Conclusion: This study showed the higher relative frequency of HPV6 and HPV11 in anogenital warts in Guilan, northern Iran. The frequency of genital HPV infection appears to be higher among men, but the frequency of high-risk types seems to be higher among women.
