Background: A wide variety of cutaneous and mucosal lesions occur in renal transplant recipients. Objectives: Evaluation of the skin and mucous membrane lesions in the kidney transplant recipients in Noor and Ali Asghar Hospital in Isfahan. Patients and Methods: This cross-sectional descriptive study was done on 117 patients (82 male, 35 female), who had received kidney transplants and referred to Noor and Ali Asghar Hospital during July and August 1997. Results: Hypertrichosis was the most common finding observed in 73%. Other lesions were acne (33%), folliculitis (26%), gingival hyperplasia (19%), common warts (18%), and recurrent herpes simplex infection (3%). Basal cell carcinoma was present in 3 patients and one patient had Kaposi’s sarcoma. Conclusion: Except for skin tumors, the results of this study revealed similar prevalence of skin lesions in renal transplantation patient with those reported in the literature, which emphasizes on the importance of periodic skin examinations in these patients.