Urticaria is a frequent and difficult-to-treat skin condition, described as temporary erythematous, raised, and itchy skin lesions (wheals) brought on by dilated blood vessels, elevated local blood flow, and increased vascular permeability. It can occur alone or in conjunction with angioedema. Urticaria can be diagnosed and treated in fields other than dermatology; patients often visit general physicians, internal medicine specialists, allergologists, and clinical immunologists. In 2018, the Iranian Society of Dermatology produced a clinical practice guideline on diagnosing and managing urticaria. To update the guideline, the Guideline Development Committee conducted an exhaustive search of scientific papers published on the topic from April 2018 to the end of August 2022, and the new guideline was developed. Finally, the updated guideline was critiqued by members of the Dermatology Board Certificate Examination Panel and chairs of dermatology departments in Iran, and it was improved using their feedback.