Document Type : Case Report


Department of Dermatology, Venereology, Leprosy, Yenepoya Medical College, Deralakatte, Mangalore, Karnataka, India


Psoriasis is a chronic inflammatory disorder, which affects the skin, nails, and joints. Psoriasis can be associated with systemic diseases such as diabetes mellitus, metabolic syndrome, renal diseases, and cardiovascular diseases.
Renal involvement among patients with psoriasis has been increasingly reported. These disorders include conditions such as IgA nephropathy, membranoproliferative glomerulonephritis, secondary renal amyloidosis, and C3 glomerulonephritis. The various clinical and laboratory features that need consideration to rule out underlying renal disease in such patients include hypertension, edema of bilateral lower limbs, microscopic hematuria, and proteinuria.
Herein, we present a case of a 49-year-old patient with chronic plaque psoriasis, who was diagnosed with nephrotic syndrome 8 years after the onset of psoriasis. Immunohistochemical analysis of the renal biopsy samples revealed membrane nephropathy with M-type phospholipase PLA 2R positivity.
Due to the concurrent presence of severe psoriasis lesions, oral corticosteroid was deferred, and the patient was treated with oral Tacrolimus 4 mg per day for membranous nephropathy, which resulted in significant improvement of cutaneous lesions.