Behcet’s disease is a multisystem disease characterized clinically by oral aphthae and occasionally by genital aphthae, cutaneous lesions such as pustular vasculitis, sweet syndrome-like, pyoderma gangrenosum-like and erythema nodosum-like lesions and variably present systemic features such as synovitis, anterior and posterior uveitis, meningoencephalitis and large vessel smaller vessel vascular disease, and Aphthae may occur throughout the entire gastrointestinal tract. We studied 26 cases of Behcet’s disease hospitalized in Sina Hospital, Ahwaz. 20 of these patients were woman (76%) and 6 were men (74%), with an age range of 13 to 43 years. All the patients had oral aphthae, 22 had genital aphthae (84%), 8 had eye disease (30%), 10 had skin lesions (34%), 10 had arthralgia and arthritis and 3 had CNS involvement as head ache.