α-Interferon is an antiviral agent used in treatment of chronic hepatitis B. Triggering of the underlying autoimmune disease or exacerbation of pre-existing auto immune disease is documented with α-interferon, but there are few reports about occurrence of autoimmune disorders such as systemic lupus erythematosus, Vitiligo, hypo and hyperthyroidism after administration of α-interferon in the literature. We report here in two cases of chronic hepatitis B treated with a-interferon, who developed Vitiliginous lesions. These lesions disappeared within 3 to 6 months after discontinuing α-interferon therapy. Until now, the occurrence of vitiligo after administration of α-interferon in chronic hepatitis B has not been reported.