Background: Humans, rodents and sandflies have role in transmitted cycle of cutaneous leishmaniasis. To control the disease, promoting the environment, killing the rodent and poisoning the vectors are recommended, individually all over the world. Since, there is no effective vaccine against this disease, the integration of methods is considerable. Objective: To evaluate the efficacy of integration method in the control of cutaneous leishmaniasis. Patients and Methods: This study was an interventional study, which after knowing the ecosystem around the Imamzadeh Agha Ali Abbas in Natanz in Isfahan, perform the plat covering within a radius of 100m, entrances correction, pool and garbage storage removal and sweepings for the rodents within a radius of 2kms around the Imamzadeh and poisoning the vectors have been done. Results: The incidence of disease was 3.7% in 1996 (Before intervention), which was decreased to 1/17 in 1996 and to 1/12 a year later. Conclusion: Integration method consisting of environment improvement, rodents removal and poisoning as well as training high risk people is recommended to control cutaneous leishmaniasis.