Maryam Khalili; simin Shamsi Meymandi; Saman Mohammadi; Mahin Aflatoonian; Elahe Kooshesh
Abstract
Background: Granulomatous skin lesions are characterized by aggregation of activated histiocytes. Granulomatous skin lesions are classified as xanthomatous, necrobiotic, tuberculoid, sarcoidal, and foreign body types. This study evaluates the clinicopathological features of patients with granulomatous ...
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Background: Granulomatous skin lesions are characterized by aggregation of activated histiocytes. Granulomatous skin lesions are classified as xanthomatous, necrobiotic, tuberculoid, sarcoidal, and foreign body types. This study evaluates the clinicopathological features of patients with granulomatous skin lesions.Methods: We conducted a cross-sectional study of 232 skin biopsies diagnosed as granulomatous skin lesions over ten years from patients referred to Afzalipour Hospital, Kerman, Iran. Demographics, clinical features of lesions, and pathological characteristics were recorded. Then, the correlation of the final diagnosis with the demographic and clinical features of the patients was assessed via the independent t-test and chi-squared test.Results: Most patients were in their third decade of life, with a male-to-female ratio of 1.05 to 1. The most common types of granuloma were tuberculoid (60.3%), necrobiotic (12.5 %), and foreign body type (11.2%). Infectious disease was the most common cause of granulomatous lesions (64.2 %); leishmaniasis constituted approximately 96% of cases. The most common causes of noninfectious granulomatous skin diseases were foreign body granuloma (26.2%), granuloma annulare (23.2%), and xanthogranuloma (12.1%). There was a significant correlation between dermatologic disease type and disease duration (P = 0.024).Conclusion: In the current study, the most common type of granuloma was tuberculoid, followed by necrobiotic and foreign body type granulomas. Infectious diseases were the most common cause of granulomatous skin lesions. Furthermore, the most common granulomatous skin diseases were leishmaniasis, foreign body granuloma, and granuloma annulare. The least common granulomatous skin lesions were sporotrichosis and gout.
Maryam Khalili; Simin Shamsi Meymandi; Mahin Aflatoonian; Ali Bagheri
Abstract
Background: Basal cell carcinoma is the most common skin cancer, constituting nearly 80% of non-melanoma skin cancers. In this study, for the first time in Kerman, the clinicopathological features of basal cell carcinoma in patients referred to Afzalipour Hospital were evaluated.Methods: This is a retrospective, ...
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Background: Basal cell carcinoma is the most common skin cancer, constituting nearly 80% of non-melanoma skin cancers. In this study, for the first time in Kerman, the clinicopathological features of basal cell carcinoma in patients referred to Afzalipour Hospital were evaluated.Methods: This is a retrospective, cross-sectional study on 145 skin biopsy samples with a diagnosis of basal cell carcinoma in Afzalipour Hospital, Kerman. Demographic features of patients and clinical and pathologic types of basal cell carcinoma were recorded. Then, the correlation between clinical or histological types with demographic features was evaluated using the chi-squared test.Results: Ninety-four (64.8%) of the cases were male, and the mean age of the patients was 68.12 ± 14.54 (min = 15, max = 101) years. The most and the least common sites of involvement were the nose (35.9%) and trunk (0.7%), respectively. The most common clinical (76.5%) and pathological subtypes (71.03%) were nodular. The least common clinical (6.3%) and pathological types (2.1%) were morpheaform. There was no significant correlation between histopathological or clinical types with demographic features including age and sex. Furthermore, there was no significant correlation between sex and the site of the involvement or age of the patients.Conclusion: In this study, most patients were between 60-79 years of age, and the male-to-female ratio was 1.8 to 1. Nodular and morpheaform types were the most and the least common pathological and clinical types, respectively.
Fatemeh Sari Aslani; Mozhdeh Sepaskhah; Mojgan Akbarzadeh Jahromi
Abstract
The rate of cosmetic tattooing in Iran is increasing as in many other countries, with concomitant rises in tattoo-associated complications, including inflammatory (infectious and noninfectious) and neoplastic reactions. We reviewed clinical and pathology features of a series of 13 cases of adverse reactions ...
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The rate of cosmetic tattooing in Iran is increasing as in many other countries, with concomitant rises in tattoo-associated complications, including inflammatory (infectious and noninfectious) and neoplastic reactions. We reviewed clinical and pathology features of a series of 13 cases of adverse reactions to tattoo pigments. The participants included 11 women and 2 men aged between 22 and 58. The histopathologic reaction patterns were seven granulomatous (four sarcoid, with heavy tattoo pigments in the superficial dermis, and three tuberculoid, with scanty tattoo pigments in the superficial dermis), three cases of pseudoepitheliomatous hyperplasia, one cutaneous lupuserythematosus-like reaction, one pseudolymphomatous reaction, and one case of mild superficial perivascular inflammation. More than two-thirds of the reactions were to brown tattoos on the eyebrows. The lag in lesion development after tattooing varied from five days to two years.
Behzad Khodaei; Simin Seyedpour; Bahareh Gholami; Kambiz Kamyab Hesari; Seyed Ahmad Seyed Alinaghi; Maryam Nasimi
Abstract
Background: Nail disorders present with a wide range of manifestations. The problems associated with nail biopsiesmake the diagnosis even more challenging. Identifying the most common features of each nail disorder can prevent unnecessary biopsies and facilitate early diagnosis.Methods: We conducted ...
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Background: Nail disorders present with a wide range of manifestations. The problems associated with nail biopsiesmake the diagnosis even more challenging. Identifying the most common features of each nail disorder can prevent unnecessary biopsies and facilitate early diagnosis.Methods: We conducted a cross-sectional study on 528 pathology reports, documented from March 2018 to March 2019 in the Razi Dermatopathology Hospital, Tehran, Iran. We extracted the demographic data and the nails’ clinical and pathologic presentations. We used Fisher’s exact test to determine the nail features’ clinicopathological correlations.Results: The mean age of the 359 included patients was 38.81 ± 18.11 years, and 50.81% were male. Benign melanonychia (12.82%), traumatic nail (11.96%), and junctional nevus (11.11%) were the most prevalent disorders. Onycholysis (P < 0.001), longitudinal ridges (P < 0.001), subungual hyperkeratosis (P = 0.003), dystrophy (P = 0.017), discoloration (P = 0.052), and pitting (P < 0.001) correlated significantly with nail psoriasis. The presence of subungual hyperkeratosis, onycholysis, and longitudinal ridges significantly increased the odds of nail lichen planus. Only 6.79% of patients with longitudinal melanonychia had malignant melanoma, while most (26.54%) correlated with benign melanonychia.Conclusions: A detailed examination can narrow the differential diagnosis and avert unnecessary biopsies. However, in high-risk cases, physicians should regularly monitor the nails’ changes and response to treatment.
Fatemeh Sari Aslani; Nasrin Saki; Mohammad Sasannia
Abstract
Background: Since its recognition, frontal fibrosing alopecia (FFA) has increasingly been studied globally in terms of its diverse aspects. Having found no studies describing this condition in Southern Iran, we examined the different clinicopathological features of patients with FFA who referred to Faghihi ...
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Background: Since its recognition, frontal fibrosing alopecia (FFA) has increasingly been studied globally in terms of its diverse aspects. Having found no studies describing this condition in Southern Iran, we examined the different clinicopathological features of patients with FFA who referred to Faghihi Hospital, Southern Iran, between 2013 and 2018. Methods: We searched the archives of the Pathology Department of Faghihi Hospital for the cases with a diagnosis of FFA. Due to its similar histopathologic features with lichen planopilaris, the final diagnosis was made using clinical correlations. Results: Twenty-two patients were enrolled; all were female. Fifteen (68.2%) presented with the disease before menopause. Besides frontal and/or temporal hairline involvement in all the patients, eyebrow alopecia, eyelash loss, body hair loss, and facial papules were present in 81.8%, 27.3%, 50%, and 68.2% of them, respectively. Dermoscopic findings included follicular opening loss (100%), honeycombing of the scalp (81.8%), multiple white dots (77.3%), perifollicular erythema (63.6%), and perifollicular scales (59.1%). The histopathologic examination revealed follicular dropout (95.4%), perifollicular lymphocytic infiltration in the infundibulum and isthmus of the follicles (81.8%), perifollicular fibroplasia (77.3%), intact interfollicular epidermis (59.1%), mild perivascular lymphocytic infiltration in the upper dermis (54.5%), and apoptotic keratinocytes in the infundibulum and isthmus (50%). The most common comorbidity was hypothyroidism (40.9%). Conclusions: Thediagnosis of FFA should be considered in both premenopausal and postmenopausal women. Eyebrow alopecia, eyelash loss, body hair involvement, and facial papules are helpful clues in the diagnosis. The coexistence of hypothyroidism with FFA suggests immunological involvement in the pathogenesis.
Ghanei Nerges; Shafihosseini Mitra; Mohammad Ebrahimzadeh Ardakani; Reza Bidaki
Abstract
Lymphangioma circumscriptum is a rare benign lymphatic malformation, clinically characterized by clusters of translucent vesicles. Uncommon manifestations such as verruciform or zosteriform have also been reported in the literature, yet eczematous-like presentation is extremely rare. The present study ...
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Lymphangioma circumscriptum is a rare benign lymphatic malformation, clinically characterized by clusters of translucent vesicles. Uncommon manifestations such as verruciform or zosteriform have also been reported in the literature, yet eczematous-like presentation is extremely rare. The present study describes the case of a young woman with a 16-year history of an exudative eczematous-like plaque, mistreated as dermatitis which converted to a semi vesicular lesion during the treatment of super infection and was later diagnosed as lymphangioma circumscriptum by histopathology study. It is suggested that since lymphangioma circumscriptum may resemble other diseases such as dermatitis, histology, as the gold standard for diagnosis, should not be forgotten in the clinical context of this entity.
A Zamanian; M Pilehvar; AR Monsef
Volume 7, Issue 3 , 2004, , Pages 140-144
Abstract
Background: Basal cell carcinoma (BCC) is the most common skin cancer in whites. Objective: Determination of anatomical localization of BCC in relation to histological subtypes of this tumor. Patients and methods: This survey is a descriptive cross sectional study carried out on 189 cases of BCC patients ...
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Background: Basal cell carcinoma (BCC) is the most common skin cancer in whites. Objective: Determination of anatomical localization of BCC in relation to histological subtypes of this tumor. Patients and methods: This survey is a descriptive cross sectional study carried out on 189 cases of BCC patients diagnosed in Hamadan Sina hospital between 1997-1999. Results: This study showed 7 histologic subtypes of BCC. Nodular type was the most common type (55.16%) and metatypical type had the lowest frequency (3.7%). Head and neck were the most common sites of all subtypes of this tumor and nose was the most common of involvement (22.7%). Conclusion: Superficial BCC was more common on the scalp, which is due to irradiation used for the treatment of tinea capitis in the past.
M Karimzadegan Nia; A Miramin Mohamadi; AR Firooz; MR Shidfar
Volume 7, Issue 2 , 2004, , Pages 95-100
Abstract
Background: At present time, the diagnosis of onychomycosis is based on clinical signs, direct exam and fungal culture, whereas Pathologic methods have shown to be more sensitive than other methods. Objective: Evaluation of pathologic methods in the diagnosis of onychomycosis in comparison to direct ...
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Background: At present time, the diagnosis of onychomycosis is based on clinical signs, direct exam and fungal culture, whereas Pathologic methods have shown to be more sensitive than other methods. Objective: Evaluation of pathologic methods in the diagnosis of onychomycosis in comparison to direct smear and culture. Patients and Methods: A nail sample was cut form 96 suspected onychomycosis patients by nail clipper. Then it was divided to four pats, and one part was stored. One part was fixed in 4% formalin and examined pathologically (PATH-PAS method). Another part was cultured in mycosil agar and Sabour and Dextrose Agar media and kept in room temperature for 4 weeks. Another part was directly examined by 10% KOH. The results of each method were recorded separately without knowing the results of others. Clinical signs with at least one positive result were considered as onychomycosis and the sensitivity of these methods were compared. Results: The most sensitive method was the combination of PATH-PAS and direct smear (98%). There was no significant difference between the sensitivity of smear and pathological method, where as PATH-PAS and culture differed significantly. Conclusion: PATH-PAS is a simple and very sensitive method in the diagnosis of onychomycosis.