Comparison of single-point injection of 50 units ofabobotulinum toxin A in the procerus muscle versus fivepointinjection methods in the treatment of glabellar lines
Background: Injectable neuromodulators are commonly used in facial aesthetic procedures, particularly for treating glabellar wrinkles. The five-point injection technique is widely utilized; however, the effectiveness of a single injection into the procerus muscle has not yet been evaluated. This study aimed to compare the efficacy of a single-point injection of 50 units of abobotulinum toxin A into the procerus muscle with that of the five-point injection technique using the same dose for treating glabellar lines. Methods: Eleven patients received a single injection of 50 units of abobotulinum toxin A into the procerus muscle, while nine patients received a total of 50 units divided equally across five injection sites. For patients requiring a touch-up injection at week two, five to ten units of abobotulinum toxin A were administered. The evaluation of results was based on measuring the distance between the medial eyebrow heads at baseline, week two and week four. Changes in this distance before and after the procedure were then analyzed. Results: Repeated measures ANOVA indicated a significant change in the distance between the medial eyebrow heads from baseline through week four for both techniques (P = 0.03 and P < 0.01 for the fivepoint and single-point injection techniques, respectively). However, there was no significant difference between the two techniques at week two and week four (P = 0.91 and P = 0.72, respectively). Conclusion: The efficacy of the single-point injection method in treating frown lines is comparable to that of five-point injection method.
Ghalamkarpour,F. , Abolhasani,E. , Ghasemloo,S. , Shafiee,A. , Hasanzadeh,S. and Mardani,G. (2025). Comparison of single-point injection of 50 units ofabobotulinum toxin A in the procerus muscle versus fivepointinjection methods in the treatment of glabellar lines. Iranian Journal of Dermatology, 28(4), 265-270. doi: 10.22034/ijd.2025.529095.2041
MLA
Ghalamkarpour,F. , , Abolhasani,E. , , Ghasemloo,S. , , Shafiee,A. , , Hasanzadeh,S. , and Mardani,G. . "Comparison of single-point injection of 50 units ofabobotulinum toxin A in the procerus muscle versus fivepointinjection methods in the treatment of glabellar lines", Iranian Journal of Dermatology, 28, 4, 2025, 265-270. doi: 10.22034/ijd.2025.529095.2041
HARVARD
Ghalamkarpour F., Abolhasani E., Ghasemloo S., Shafiee A., Hasanzadeh S., Mardani G. (2025). 'Comparison of single-point injection of 50 units ofabobotulinum toxin A in the procerus muscle versus fivepointinjection methods in the treatment of glabellar lines', Iranian Journal of Dermatology, 28(4), pp. 265-270. doi: 10.22034/ijd.2025.529095.2041
CHICAGO
F. Ghalamkarpour, E. Abolhasani, S. Ghasemloo, A. Shafiee, S. Hasanzadeh and G. Mardani, "Comparison of single-point injection of 50 units ofabobotulinum toxin A in the procerus muscle versus fivepointinjection methods in the treatment of glabellar lines," Iranian Journal of Dermatology, 28 4 (2025): 265-270, doi: 10.22034/ijd.2025.529095.2041
VANCOUVER
Ghalamkarpour F., Abolhasani E., Ghasemloo S., Shafiee A., Hasanzadeh S., Mardani G. Comparison of single-point injection of 50 units ofabobotulinum toxin A in the procerus muscle versus fivepointinjection methods in the treatment of glabellar lines. Iran J Dermatol, 2025; 28(4): 265-270. doi: 10.22034/ijd.2025.529095.2041
