Iranian Journal of Dermatology

Exploring the efficacy of nitroglycerin in filler-induced facialskin ischemia: a narrative review

Document Type : Review Article

Authors

Mohammad Darayesh 1
Zahra Khodabakhshian 2
Navid Kalani 3

1 Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Dermatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran

https://doi.org/10.22034/ijd.2025.523479.2024
Abstract
Background: Filler-induced facial skin ischemia is a potential complication of dermal filler injections that can result in tissue damage and necrosis. Due to its vasodilatory properties, nitroglycerin has been proposed as a treatment option; however, its effectiveness in this context remains uncertain.
Method: A narrative review was conducted to investigate the existing evidence on the effectiveness of nitroglycerin in treating filler-induced facial skin ischemia. Relevant studies were identified through searches of electronic databases and manual screening of reference lists.
Results: findings demonstrated limited evidence supporting the efficacy of the nitroglycerin in this context. Although there are case studies indicate that the combination of nitroglycerin and hyaluronidase effectively treats filler-induced facial skin ischemia, only one case report demonstrates the efficacy of nitroglycerin alone. Furthermore, a rat model showed no benefits from nitroglycerin and revealed harmful results.
Conclusion: The evidence regarding the efficacy of nitroglycerin in treating filler-induced facial skin ischemia is inconclusive, which calls into question its routine use. Further studies are needed to ascertain the efficacy of nitroglycerin both as a standalone treatment and in combination with other therapies for this condition. Clinicians should consider the limited available data when selecting treatment options for individuals with filler-induced facial skin ischemia.

Keywords

nitroglycerin
facial
skin ischemia
dermal fillers
skindiseases
vascular
Iranian Journal of Dermatology
Volume 28, Issue 4 - Serial Number 114
December 2025
Pages 271-278

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