Background: Pityriasis rosea is an inflammatory skin disorder with a known response to erythromycin. Considering similarities between erythromycin and azithromycin and lesser adverse effects of the latter, in a pilot study, we gave azithromycin to seven patients with pityriasis rosea and observed a noticeable improvement. The aim of this study was to evaluate the efficacy of azithromycin in patients with pityriasis rosea. Methods: A double-blind, placebo-controlled clinical trial was performed in our clinic. Sixty patients over a period of 20 months were alternatively assigned to the treatment group or the placebo group. Patients in the treatment group received azithromycin, 250 mg/day, for 14 days. The response was categorized as complete response, partial response, or no response. All patients were followed up for 2 months. Results: Age at presentation, sex, and average duration of the disease were comparable in both groups. Complete response was observed in 19 patients (63.3 %) in the treatment group and two in the placebo group (p<0.0001). Conclusion: Oral azithromycin is effective in treating patients with pityriasis rosea.
Amir Hooshang,E. , Siavash,T. , Pedram,N. , Mahboubeh,H. and Leila,N. (2008). Azithromycin in Pityriasis Rosea: A Double-Blind, Placebo-Controlled Clinical Trial. Iranian Journal of Dermatology, 11(4), 143-146.
MLA
Amir Hooshang,E. , , Siavash,T. , , Pedram,N. , , Mahboubeh,H. , and Leila,N. . "Azithromycin in Pityriasis Rosea: A Double-Blind, Placebo-Controlled Clinical Trial", Iranian Journal of Dermatology, 11, 4, 2008, 143-146.
HARVARD
Amir Hooshang E., Siavash T., Pedram N., Mahboubeh H., Leila N. (2008). 'Azithromycin in Pityriasis Rosea: A Double-Blind, Placebo-Controlled Clinical Trial', Iranian Journal of Dermatology, 11(4), pp. 143-146.
CHICAGO
E. Amir Hooshang, T. Siavash, N. Pedram, H. Mahboubeh and N. Leila, "Azithromycin in Pityriasis Rosea: A Double-Blind, Placebo-Controlled Clinical Trial," Iranian Journal of Dermatology, 11 4 (2008): 143-146,
VANCOUVER
Amir Hooshang E., Siavash T., Pedram N., Mahboubeh H., Leila N. Azithromycin in Pityriasis Rosea: A Double-Blind, Placebo-Controlled Clinical Trial. Iran J Dermatol, 2008; 11(4): 143-146.
