Saman Ahmad Nasrollahi; Zaynab Variji; Zahra Ghasemi; Somayeh Yadangi; Aniseh Samadi; Alireza Firooz
Abstract
Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated ...
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Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated in this study. The anti-cellulite lotion and placebo were applied twice daily on the thighs and buttocks for two months. Treated areas were photographed, and the thigh circumference, subcutaneous fat thickness, and dermal echo density were assessed and compared before and after the treatment. The satisfaction of the participants was also assessed.Results: A comparable improvement in cellulite grade was detected by a blinded dermatologist on both treatment sides. Cellulite improved much in one participant, improved in six, and did not change in three participants. The dermis thickness increased compared with placebo after two months (P = 0.046). A significant reduction was observed in subcutaneous fat thickness on the treated side (P = 0.03). However, the decrease was not significant on the placebo site. There was an increase in the echo density of the dermis in the treatment site, though it was not statistically significant. Both products were well tolerated, and none of the participants experienced skin burning or itching.Conclusion: The studied anti-cellulite lotion reduced the thickness of subcutaneous fat and increased the dermis thickness without serious adverse effects.
Setareh Ameri; Saman Ahmad Nasrollahi; Aniseh Samadi; Fatemeh Amiri; Solmaz Ahmadvand; Somayeh Yadangi; Mahsa Fattahi; Marzieh Ehsani; Alireza Firooz
Abstract
Background: Hand hygiene plays a vital role in controlling pathogenic microorganisms’ transmission and maintaining the interaction between skin microbiota and biometric parameters. This study evaluated the effects of hand cleansers including alcoholic gel, alcoholic pad, antibacterial, and simple ...
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Background: Hand hygiene plays a vital role in controlling pathogenic microorganisms’ transmission and maintaining the interaction between skin microbiota and biometric parameters. This study evaluated the effects of hand cleansers including alcoholic gel, alcoholic pad, antibacterial, and simple wipes on skin biometric parameters and microbiota.Methods: Samples were collected from the hands of 15 healthy office workers with a mean age of 37.70 ± 9.6 years. Then, the subjects were instructed to use cleansers in four following rounds, with a one-week washout period between the rounds. Sample collection was performed before, right after, and one hour after using the cleansers. Microbial isolates were investigated via standard microbiological techniques, and biometric measurements were made using the Cutometer® MPA 580. The obtained data were analyzed using the paired t-test and repeated measures ANOVA.Results: Overall, there were no significant differences between cleansers in reducing the total aerobic microbial count (TAMC). Also, there was an approximate return to the initial count of resident microbiota one hour after using the alcoholic pad. A significant difference was observed in decreasing the Staphylococcus aureus count using antibacterial wipes rather than simple wipes. Simple wipes had the most increasing effect on transepidermalwater loss (TEWL), showing a significant difference with the alcoholic gel. Furthermore, alcoholic gel caused a greater pH decrease in comparison to other products.Conclusion: Alcoholic cleaners are more effective than antibacterial and simple wipes due to maintaining the skin’s biometric parameters. An additional advantage is that alcoholic pads can preserve the resident microbiota.
