Mohammad Ali Mapar; Simin Mansorian; Nader Pazyar; Mohammadreza Keshavarz; Atefeh Mansorian
Abstract
Background: Warts are among the most common skin diseases with various recommended treatments, including topical ablation, chemotherapy, and immunotherapy. However, given the unsatisfactory response rate, complications, and recurrence, effective treatment remains controversial. This study compared formalin ...
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Background: Warts are among the most common skin diseases with various recommended treatments, including topical ablation, chemotherapy, and immunotherapy. However, given the unsatisfactory response rate, complications, and recurrence, effective treatment remains controversial. This study compared formalin against an anti-wart compound containing salicylic acid and lactic acid.Methods: This clinical trial recruited 58 patients with wart lesions on hands and feet randomly divided into two groups of daily topical treatment: formalin 5% (n = 29) and anti-wart lotion containing salicylic acid 16.7% and lactic acid 16.7% in flexible collodion (n = 29) for eight weeks. Patient satisfaction and recovery were assessed and compared between the groups at weeks four and eight.Results: Patient satisfaction did not change significantly in either group (P > 0.05), and no significant difference was observed between the groups (P = 0.838). The number of wart lesions fell significantly after eight weeks in both groups (P < 0.001), with no significant difference between them (P = 0.225). There was no significant difference between the two methods in terms of side effects (P = 0.084).Conclusion: Both formalin and salicylic acid plus lactic acid lotion effectively treated plantar and common warts, and neither had any significant side effects. The treatment choice should be based on the patient’s age, the number of lesions, and the site affected.
Ria Rai; Varsha Jamale
Abstract
Background: Cutaneous verrucae (warts) are benign epithelial proliferations caused by human papillomavirus (HPV). HPV acts by upregulating epithelial cell replication and downregulating host immune responses. Hence, treatment could be aimed at the virus (via antiviral drugs like valacyclovir) or the ...
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Background: Cutaneous verrucae (warts) are benign epithelial proliferations caused by human papillomavirus (HPV). HPV acts by upregulating epithelial cell replication and downregulating host immune responses. Hence, treatment could be aimed at the virus (via antiviral drugs like valacyclovir) or the immune system (via immunomodulators like zinc sulfate). It is important to identify which pathogenesis should be preferably targeted for safe and effective therapy. We aimed to compare the efficacy and safety of oral valacyclovir versus oral zinc sulfate in the treatment of cutaneous verruca.Methods: Fifty patients clinically diagnosed with warts were randomly divided into two groups: Group A (n = 25), treated with oral valacyclovir (1000 mg/day), and Group B (n = 25), treated with oral zinc sulfate (400 mg/day). All patients were evaluated using a Visual Analogue Scale (VAS) and the Physician’s Global Assessment (PGA) and were followed up for 12 weeks. The results were analyzed using R software version 3.6.0.Results: A significant decrease in the number of warts from baseline to the fifth follow-up visit was noted in Group A (P < 0.05) but not in Group B (P > 0.05). Both the groups showed a significant improvement visit-wise (P < 0.05) with respect to both VAS and PGA scores, but Group A (25.00 ± 28.58 and 1.60 ± 1.61; P < 0.05) showed marked improvement compared to Group B (60.40 ± 8.89 and 2.96 ± 0.35; P < 0.05).Conclusion: Oral valacyclovir is more efficacious than oral zinc sulfate in the treatment of cutaneous verrucae. Both are equally safe.
Ali Asilian; Zabihollah Shahmoradi; Shahryar Rahmani; Hossein Hafezi; Samaneh Mozafarpoor
Abstract
Background: Bleomycin is used for the treatment of warts. However, only its injected form can be used due to systemic use side effects, and plantar warts have a high recurrence rate following administration of bleomycin tattooing alone. To find an effective alternative with fewer side effects, we decided ...
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Background: Bleomycin is used for the treatment of warts. However, only its injected form can be used due to systemic use side effects, and plantar warts have a high recurrence rate following administration of bleomycin tattooing alone. To find an effective alternative with fewer side effects, we decided to investigate the effectiveness of bleomycin tattooing combined with trichloroacetic acid (TCA) and shaving in the management of treatment-resistant plantar warts.
Methods: The patients with treatment-resistant plantar warts entered the present quasi-experimental study. the wart site was shaved ahead of bleomycin tattooing and TCA peeling. This treatment was provided at one-month intervals and was repeated a maximum of four times. Patients were followed for six months after completion of the therapy. Finally, the patients’ data were completed according to photographs (monthly photos taken of lesions) and careful examinations.
Results: The present study involved 56 patients with a mean age of 25.75 ± 12.22 years. Twelve patients (21.4%) recovered after the first treatment; 14 (25%) needed the second treatment, 12 (21.4%) needed the third, 10 (17.9%) the fourth, and eight (14.3%) did not recover after the fourth treatment. The recovery rate was 21.4% with one, 45.4% with two, 66.8% with three, and 85.7% with four treatment sessions.
Conclusion: The combination treatment of bleomycin plus TCA and shaving led to a remarkable recovery from treatment-resistant plantar warts (21.4% recovery with the first treatment session and up to 85.7% recovery after four sessions). The treatment included tattooing and local injections, leaving few side effects.
Azadeh Goodarzi; Mahsa Farshidzadeh; Elham Behrangi; Mohammadreza Ghassemi; Masoumeh Roohaninasab
Abstract
Viral skin diseases range from simple superficial exanthems to complex systemic diseases, affecting people of all ages. Careful assessment of infectious contacts and immunization status is of considerable importance along with a thorough physical examination. Recent research has linked a deficiency of ...
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Viral skin diseases range from simple superficial exanthems to complex systemic diseases, affecting people of all ages. Careful assessment of infectious contacts and immunization status is of considerable importance along with a thorough physical examination. Recent research has linked a deficiency of vitamin D to an increased risk of autoimmune, infectious, and atopic disorders. Intralesional vitamin D3 may be an effective treatment option for warts. Vitamin D3 derivatives are effective for various skin conditions, including psoriasis, transient acantholytic dermatosis, actinic porokeratosis, and keratosis palmaris et plantaris. Vitamin D3 treatment has been shown to decrease chemokine synthesis and monocyte trafficking, as well as to downregulate toll-like receptors (TLRs) 2 and 4 of monocytes. This suggests an association between TLRs and vitamin-D-mediated innate immunity. The effect of vitamin D derivatives was speculated to be derived from its potential to regulate epidermal cell proliferation and differentiation and to modulate cytokine production. According to some studies gathered here, not only we can use different forms of vitamin D as therapy for viral skin disease, but also there is an important relationship between them. Therefore, we should consider the serum level of vitamin D for better management of these disorders. Also, keeping vitamin D levels within the normal range may be a preventative healthcare strategy.
SK Alavi Fazel; SM Radmanesh
Volume 2, Issue 2 , 1999, , Pages 34-38
Abstract
Hypnotherapy is recommended for recalcitrant cases of many dermatologic disorders including viral warts, chronic urticarias, psoriasis and alopecia areata. A 23-year old, married lady referred with five years history of confluent verrucous and cauliflower type of viral warts on the dorsum of right foot ...
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Hypnotherapy is recommended for recalcitrant cases of many dermatologic disorders including viral warts, chronic urticarias, psoriasis and alopecia areata. A 23-year old, married lady referred with five years history of confluent verrucous and cauliflower type of viral warts on the dorsum of right foot and many discrete warty papules on the left foot and toes and on different aspects of both hands and fingers. She had tried many medical modalities and surgical procedures including: keratolytics, formalin application, electrocauterization, curettage, cryotherapy with no satisfactory effect. As the patient was quite frustrated with no more trust on physical therapies, she was advised to be treated by hypnotherapy. After patient’s consent, she was scheduled for 20 hypnotherapy sessions with weekly interval. The papules on the hands disappeared after the second session and those of the right foot started to improve after the tenth session. Complete eradication occurred before the 20th session. Although hypnotherapy is time consuming, it is recommended for recalcitrant cases of viral warts.