Ananya B Reddy; Malcolm Pinto; Santhosh Pai; Spandana P Hegde; Manjunath M Shenoy
Abstract
Psoriasis is a chronic inflammatory disorder, which affects the skin, nails, and joints. Psoriasis can be associated with systemic diseases such as diabetes mellitus, metabolic syndrome, renal diseases, and cardiovascular diseases.Renal involvement among patients with psoriasis has been increasingly ...
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Psoriasis is a chronic inflammatory disorder, which affects the skin, nails, and joints. Psoriasis can be associated with systemic diseases such as diabetes mellitus, metabolic syndrome, renal diseases, and cardiovascular diseases.Renal involvement among patients with psoriasis has been increasingly reported. These disorders include conditions such as IgA nephropathy, membranoproliferative glomerulonephritis, secondary renal amyloidosis, and C3 glomerulonephritis. The various clinical and laboratory features that need consideration to rule out underlying renal disease in such patients include hypertension, edema of bilateral lower limbs, microscopic hematuria, and proteinuria.Herein, we present a case of a 49-year-old patient with chronic plaque psoriasis, who was diagnosed with nephrotic syndrome 8 years after the onset of psoriasis. Immunohistochemical analysis of the renal biopsy samples revealed membrane nephropathy with M-type phospholipase PLA 2R positivity.Due to the concurrent presence of severe psoriasis lesions, oral corticosteroid was deferred, and the patient was treated with oral Tacrolimus 4 mg per day for membranous nephropathy, which resulted in significant improvement of cutaneous lesions.
Nazemi-Tabrizi Mohammad-Javad; Hatami Parvaneh; Ghiasi Maryam; Daneshpazhooh Maryam; Chams-Davatchi Cheyda
Volume 15, Issue 2 , 2012, , Pages 42-46
Abstract
Background: Pemphigus vulgaris is a rare autoimmune disorder characterized by cutaneous and mucosal blistering. Surprisingly, the management of oral lesions has been detailed only infrequently. As current topical therapies for oral lesions are of limited efficacy, application of calcineurin inhibitors ...
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Background: Pemphigus vulgaris is a rare autoimmune disorder characterized by cutaneous and mucosal blistering. Surprisingly, the management of oral lesions has been detailed only infrequently. As current topical therapies for oral lesions are of limited efficacy, application of calcineurin inhibitors is considered to be a potential option. The aim of this essay was to investigate the efficacy of tacrolimus 0.1% ointment (Protopic®) versus triamcinolone acetonide 0.1% paste (Volon-A®) in the treatment of oral pemphigus vulgaris. Method: Fifteen patients were involved in a prospective randomized trial with a split- mouth design. After two weeks of administering study drugs, oral lesions were monitored and quantified pain and mucosal surface involvement scores were obtained. Result: Within 14 days, the degree of involvement and pain scores significantly reduced in both tacrolimus-treated and triamcinolone-treated sites, but there was no significant difference between them. No severe adverse events were observed. Conclusion: This study showed that tacrolimus could be as effective as triamcinolone acetonide in the topical treatment of oral pemphigus vulgaris.
