A 30-year-old woman was referred to us with red and firm nodules on upper lateral aspect of left arm. These nodules were present for 15 years without pain but with intense pruritus.
She reported uterine leiomyoma in the past, but family history for similar lesions was negative. Blood tests were normal, but pelvis ultrasound showed a large uterine leiomyoma.
Histologic examination of cutaneous lesions showed proliferation of smooth muscle cells with fascicular pattern in dermis. Pruritus was controlled with oral anti-histamine (loratadine). Plastic surgeons refused to remove the skin lesions due to their location and widespread distribution.