Original Article
Jatana Gurpoonam; Gupta Sunil Kumar; Kaushal Sandeep; Kajal Shobhna; Kaur Sandeep
Volume 20, Issue 4 , 2017, Pages 103-112
Abstract
Background: Adverse cutaneous drug reactions are unwarranted effects of modern medicine. These unfortunate events can assume any morphology from simple exanthem to full blown toxic epidermal necrolysis (TEN), and can simulate and mimic many diseases. Sometimes it is difficult to recognize the cause, ...
Read More
Background: Adverse cutaneous drug reactions are unwarranted effects of modern medicine. These unfortunate events can assume any morphology from simple exanthem to full blown toxic epidermal necrolysis (TEN), and can simulate and mimic many diseases. Sometimes it is difficult to recognize the cause, but they may be due to polypharmacy or self-administration of medications. The analytical data from this study might help us to see certain patterns with various drugs and shed light on this problem. We performed this study at a tertiary hospital in Punjab, Dayanand Medical College and Hospital (DMCH), in order to determine the clinical patterns of cutaneous manifestations of adverse drug reactions (ADR).Methods: The diagnosis was mainly based on detailed history and correlation between drug intake and the onset of rash along with laboratory investigations and skin biopsy results where possible. We assessed 695 patients (379 males and 316 females) who presented with cutaneous drug reactions over a 12-month period.Results: The most common benign ADR observed was exanthem, which affected 199 (28.64%) patients followed by acute urticaria, including angioedema, which was seen in 126 (18.13%) patients, and fixed drug eruption (FDE) in 105 (15.11%) that included bullous FDE reactions. Other reactions included Stevens-Johnson syndrome (SJS) and TEN in 39 (5.61%) patients, erythroderma in 27 (3.88%), hotosensitivity reactions, including phototoxic and photosensitive reactions, 31(4.46%), and lichenoid eruptions in 25(3.59%) patients.Conclusion: Exanthems were the most common drug eruptions observed. Antibiotics and NSAIDS were the most common causes for benign drug eruptions, whereas antiepileptics were a major cause of severe cutaneous adverse reactions (SCARs).
Original Article
Namazi Nastaran; Helali Maryam; Pishgahi Mehdi; Ketabi Yasaman
Volume 20, Issue 4 , 2017, Pages 113-117
Abstract
Background: Psoriasis is a prevalent chronic T cell mediated inflammatory skin disorder. Recent studies have reported an increase in the incidence of arrhythmia in psoriasis patients who run an excessive risk of metabolic syndrome and cardiovascular diseases. P-wave dispersion (PWD) and duration are ...
Read More
Background: Psoriasis is a prevalent chronic T cell mediated inflammatory skin disorder. Recent studies have reported an increase in the incidence of arrhythmia in psoriasis patients who run an excessive risk of metabolic syndrome and cardiovascular diseases. P-wave dispersion (PWD) and duration are important electrocardiographic (ECG) markers employed to anticipate the risk of atrial arrhythmias. The objective of this research was to investigate the risk of atrial arrhythmia by measuring PWD, and maximum and minimum p-wave duration in psoriasis patients without known cardio metabolic risk factors.Materials and Methods: ECG was evaluated in Sixty-five adult patients with psoriasis and sixty-five age-, gender- and BMImatched healthy individuals.Results: Maximum P-wave duration (P max) and PWD were significantly higher in patients compare with the controls.Conclusion: It seems that psoriasis patients run a higher risk of developing atrial arrhythmia even following the adjustment of cardio metabolic risk factors.
Original Article
Ehsani Amir Hooshang; Noormohammadpoor Pedram; Sadeghinia Ali; Hemmati Sara; Ahmadi Maedeh; Sotoudeh Sara; Azizpour Arghavan; Nasimi Maryam
Volume 20, Issue 4 , 2017, Pages 118-121
Abstract
Background: Basal cell carcinoma (BCC), the most common form of skin cancer, usually occurs in the sun-exposed areas of the body like head and neck, yet is also seen in unexpected sites. Myriad studies have mentioned a lower limb BCC incidence rate of 1.5-13.5%.Methods: The present retrospective cross-sectional ...
Read More
Background: Basal cell carcinoma (BCC), the most common form of skin cancer, usually occurs in the sun-exposed areas of the body like head and neck, yet is also seen in unexpected sites. Myriad studies have mentioned a lower limb BCC incidence rate of 1.5-13.5%.Methods: The present retrospective cross-sectional study was conducted on 650 BCC patients, who were referred to the dermatology tumor clinic of Razi hospital from 2008 to 2012 with confirmed biopsy results of BCC. Patient characteristics including age, sex, relevant history and physical examination and tumor characteristics such as location and pathological subtypes were recorded.Results: The prevalence of lower limb BCC was 1.53% with the mean age of 69.5 years and a male to female ratio of 2.33:1. Of 10 cases with BCC on the lower extremities, 6 were on the legs, 3 on the thighs and 1 on the foot. The most frequent pathological type was nodular and constant UV exposure was the most important risk factor (60%). Other underlying factors were chemical exposure, chronic ulcer and history of radiation.Conclusion: BCC of the lower limbs is more prevalent in men compared with women. Moreover, UV exposure is the most important risk factor for BCC. On the other hand, factors like ulcers, radiation and chemical exposure have to be further considered.
Original Article
Zabolinejad Naghmeh; Hoseininejad Masoumeh; Jannatipour Maryam; Layegh Pouran
Volume 20, Issue 4 , 2017, Pages 122-126
Abstract
Background: Hair loss is a major cause of dermatology visits resulting in considerable anxiety and distress for patients. The objective of the current research was to investigate the association among various diagnostic methods related to non-scarring hair loss in women. Methods: After obtaining the ...
Read More
Background: Hair loss is a major cause of dermatology visits resulting in considerable anxiety and distress for patients. The objective of the current research was to investigate the association among various diagnostic methods related to non-scarring hair loss in women. Methods: After obtaining the complete history, clinical examination was carried out on women suffering from diffuse nonscaring alopecia. Laboratory tests and histo-pathologic study were conducted for each patient, and ultimately, data were analyzed by SPSS version 16. Result: Forty-one women were enrolled with the average age of 28.1±8.4 years (16-48). Mean duration of hair loss was 6.2 years (2 months-20 years). The most prevalent type of hair loss was androgenetic alopecia. The sensitivity and specificity with which the clinical examination was done to detect this common ilk of hair loss was 94% and 25%, respectively. No acceptable correlation existed between laboratory test results (such as testosterone, DHEAS, ferritin and TSH) and clinical diagnosis. Data were further assessed through the use of IBM SPSS software version 22 using fisher exact test and Kappa coefficient. The significance level was set at p<0.05. Conclusion: Clinical examination is an accurate approach to diagnosing certain types of non-scarring hair loss in women, eliminating the necessity to perform various endocrinology and laboratory tests; however, it is only through histopathologic studies that an exact diagnosis is specified.
Case Report
Volume 20, Issue 4 , 2017, Pages 127-130
Abstract
Kasabach-merritt syndrome is a rare life-threatening syndrome associated with vascular tumors such as tufted angioma and kaposiform hemangioendothelioma. For this syndrome, there exist a few treatment modalities with variable results. For many years, corticosteroids have been employed in the first-line ...
Read More
Kasabach-merritt syndrome is a rare life-threatening syndrome associated with vascular tumors such as tufted angioma and kaposiform hemangioendothelioma. For this syndrome, there exist a few treatment modalities with variable results. For many years, corticosteroids have been employed in the first-line therapy. Nowadays, on the other hand, β blockers such as propranolol have been used owing to their acceptable efficacy and fewer side effects. In the present case report, atenolol combined with corticosteroid was, for the first time, prescribed for the treatment of the syndrome; a significant improvement was observed with no concomitant side effects.
Case Report
Mohammadi Saman; Khalili Maryam; Fadai Fahameh; Badakhsh Hoda; Farajzadeh Saeedeh; Mohebbi Azadeh; Aflatoonian Mahin
Volume 20, Issue 4 , 2017, Pages 131-134
Abstract
Goltz syndrome or focal dermal hypoplasia is a rare syndrome with mesoectodermal hypoplasia. This syndrome is an X-linked dominant disorder with involvement of the cutaneous, ocular, dental and skeletal systems. The most significant feature of this disease is connective tissue dysplasia. Here, we report ...
Read More
Goltz syndrome or focal dermal hypoplasia is a rare syndrome with mesoectodermal hypoplasia. This syndrome is an X-linked dominant disorder with involvement of the cutaneous, ocular, dental and skeletal systems. The most significant feature of this disease is connective tissue dysplasia. Here, we report a 30-year old woman who presented with congenital unilateral linear atrophic areas on her trunk, back, and upper and lower extremit
Case Report
Ardakani Mohammad Ebrahimzadeh; Binesh Fariba; Shafihosseini Mitra; Herati Parvaneh Dehghan
Volume 20, Issue 4 , 2017, Pages 135-137
Abstract
Pemphigus foliaceus is an autoimmune blistering condition more often than not associated with generalized lesions. Localized Pemphigus foliaceus is a rare entity. Herein, we report a case of pemphigus foliaceus localized on the face. A 64-year-old woman was referred to our clinic with a 2-year history ...
Read More
Pemphigus foliaceus is an autoimmune blistering condition more often than not associated with generalized lesions. Localized Pemphigus foliaceus is a rare entity. Herein, we report a case of pemphigus foliaceus localized on the face. A 64-year-old woman was referred to our clinic with a 2-year history of erythematous plaque on the right side of her face. The histology report was compatible with pemphigus foliaceus. The lesion improved completely in response to oral prednisolone at 40 mg daily. Pemphigus foliaceus has to be suspected in presumed eczema that is refractory to appropriate topical corticosteroid treatment. A histopathologic study is required to establish localized pemphigus foliaceus.
