Handjani Farhad; Kalafi Amir
Volume 16, Issue 4 , 2013, , Pages 128-131
Abstract
Background: Chronic skin diseases such as vitiligo and psoriasis can impair the quality of life in the patients with these diseases. The impact of chronic and/or severe skin diseases on the lives of family members of the affected patients has only recently been addressed. The tool used for this assessment ...
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Background: Chronic skin diseases such as vitiligo and psoriasis can impair the quality of life in the patients with these diseases. The impact of chronic and/or severe skin diseases on the lives of family members of the affected patients has only recently been addressed. The tool used for this assessment is the Family Dermatology Life Quality Index (FDLQI). The aim of this study was to use the FDLQI to assess the impact of four skin diseases (pemphigus, psoriasis, vitiligo, and cutaneous leishmaniasis) on family members of the affected patients.Method: Fifty healthy family members of 50 patients with pemphigus, psoriasis, vitiligo, and cutaneous leishmaniasis were included in this study. The patients had to have an extensive disease with disease duration of at least one month. One family member of each patient completed the 10- item Persian version of the FLDQI questionnaire. The score of this index ranged from 0 to 30.Result: The mean duration and mean FDLQI score of the diseases were as follows: psoriasis (mean duration=4.1±2.7, mean FDLQI score=14.7±5.01), pemphigus (mean duration=3.6±2.3, mean FDLQI score=15.4±4.7), vitiligo (mean duration=5.1±4.05, mean FDLQI score=14.4±5.08) and cutaneous leishmaniasis (mean duration=0.62±0.23, mean FDLQI score=12.0±4.3). There was no significant difference among the groups (p=0.562). In addition, no strong correlation was observed between the mean duration of the disease and mean FDLQI scores for each condition (r=0.051, p=0.726).Conclusion: This small-scale study demonstrated that although not statistically significant, inflammatory diseases like pemphigus had a higher FDLQI score when compared to non-inflammatory conditions like vitiligo and short-term conditions such as leishmaniasis.
Mashayekhi Vahid; Mahmoudi Mahmoud; Rastin Maryam; Tayebi Naser; Taheri Ahmad Reza; Tavakoli Maryam
Volume 15, Issue 3 , 2012, , Pages 69-73
Abstract
Background: Chronic lupoid leishmaniasis (CLL) is a chronicform of cutaneous leishmaniasis that is usually resistant to antileishmania agents and leishmania is not seen in the histologicsections. We used polymerase chain reaction (PCR) to detectleishmania DNA in CLL specimens.Method: This descriptive ...
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Background: Chronic lupoid leishmaniasis (CLL) is a chronicform of cutaneous leishmaniasis that is usually resistant to antileishmania agents and leishmania is not seen in the histologicsections. We used polymerase chain reaction (PCR) to detectleishmania DNA in CLL specimens.Method: This descriptive cross sectional study was done on20 paraffin embedded specimens of CLL cases referred to thedermatology clinic of Imam Reza Hospital, Mashhad, Iran.Patients’ information including age, sex, duration and location ofthe lesion was obtained and then skin specimens were reviewedhistopathologically and assessed for leishmania DNA using PCR.Result: Eleven male and 9 female patients with a mean age of17.95 years were included in our study. The
Simin Shamsi Meymandi; Manzumeh Shamsi Meymandi; Soodabeh Zandi; Shahriar Dabiri; Mahin Aflatoonian
Volume 14, Issue 2 , 2011, , Pages 42-47
Abstract
Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy ...
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Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy vs. intralesional meglumine antimoniate (MA) in treatment of anthroponotic (dry type) CL. Method: This is a prospective, randomized, open trial study (from Iran) from September 2008 to September 2010, including 50 patients (25 patients in the combined imiquimod and cryotherapy group and 25 patients in the intralesional MA group). Patients were randomly assigned to receive combined cryotherapy biweekly with imiquimod three times per week or intralesional MA weekly until complete cure or up to 12 weeks, whichever earlier. The primary end point was clinical cure, defined as complete re-epitelialization of 100%, complete flattening of induration compared with baseline at weeks 2, 6, 12 and follow up were done 1, 2 and 3 months after complete cure. Results: 50 participants divided into 25 patients in group A and 25 patients in group B completed the study. Complete cure was 65.5% (16/24 patients) in group A and 83.3% (19/23 patients) in group B. No complication was detected in patients treated with MA. Pain and eczematous reaction were detected by 4 patients and local infection in 1 patient treated with imiquimod. Conclusion: Although Meguimine antimoniate seems to be a more effective therapy for cutaneous leishmaniasis, this study revealed no significant difference in clinical response between combination of imiquimod and cryotherapy with intralesional MA in patients with cutaneous leishmaniasis in an endemic area of L. tropica.
Farajzadeh Saeedeh; Zandi Soodabeh; Vares Behrooz; Sharifzadeh Mahdiyeh; Fekri Ali-Reza
Volume 11, Issue 1 , 2008, , Pages 21-24
Abstract
Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of ...
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Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of this study was to compare the frequency and clinical presentations of cutaneous leishmaniasis in atopic dermatitis patients with the control group in an outpatient clinic in Kerman.Methods: This was a case – control study done on 459 patients with atopic dermatitis, who were diagnosed based on Hanifin & Rajka criteria and 400 healthy subjects without immunosuppression as our control group. The frequency of leishmaniasis was investigated in both groups according to age, gender and residential area.Results: Among 459 atopic dermatitis patients, 232 were female and 227 were male. Control group consisted of 232 males and 168 females. The mean age of the atopic dermatitis patients and the controls was 9.2 and 13.3 years, respectively (p0.05%). There was no statistically significant difference in clinical presentations of leishmaniasis between two groups.Conclusion: In this study there was no significant relationship between leishmaniasis and atopic dermatitis. This finding can be due to the small sample size or the difference between case and control groups regarding age.
Rahmat-allah Salmanpour; Mohammad Bahmani
Volume 10, Issue 4 , 2007, , Pages 278-282
Abstract
Background and aim: Cutaneous leishmaniasis is a common disease in the world and is an endemic disease in Iran. Highly variable results of systemic treatment of cutaneous leishmaniasis with levamisole have been reported in literature so far. The purpose of this study was to evaluate the efficacy and ...
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Background and aim: Cutaneous leishmaniasis is a common disease in the world and is an endemic disease in Iran. Highly variable results of systemic treatment of cutaneous leishmaniasis with levamisole have been reported in literature so far. The purpose of this study was to evaluate the efficacy and tolerability of levamisole as an adjuvant therapy with intralesional Glucantime.Materials and methods: Sixty patients with cutaneous leishmaniasis were included in this clinical trial. The patients were divided randomly in two groups. Thirty patients in group 1 received intralesional Glucantime along with placebo (vitamin B complex tablets, 1 tablet every 8 hours for 2 successive days per week) and 30 patients in group 2 received intralesional Glucantime plus levamisole 150 mg tablet every 8 hours in two successive days per week in adults and 3-5 mg/kg for children under 30 kg for 6 weeks.Results: The clinical response of combination therapy (78%) was significantly better then group 1 (64%), the difference was statistically significant (p<0.001). The difference in rate of re-epithelization between the two groups was also statistically significant (p<0.01).Conclusion: This study demonstrated that levamisole can he used as an adjuvant therapy in combination with intralesional Glucantime for the treatment of cutaneous leishmaniasis.
Nilforoushzadeh Afshar Mohammad Ali; Jaffari Fariba; Ansari Nazli; Moradi Shahram
Volume 10, Issue 3 , 2007, , Pages 181-186
Abstract
Background and aim: The scars of the cutaneous leishmaniasis and psychologic problems of this disease needs different intervention for its correction. Our objective in this study was to compare the efficacy of trichloroacetic acid (TCA) 50 percent solution and CO2 laser for treatment of the atrophic ...
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Background and aim: The scars of the cutaneous leishmaniasis and psychologic problems of this disease needs different intervention for its correction. Our objective in this study was to compare the efficacy of trichloroacetic acid (TCA) 50 percent solution and CO2 laser for treatment of the atrophic scars due to leishmaniasis. Materials and methods: This was a randomized clinical trial perfomed in 92 patients. Patients were randomized into 2 groups, first group were treated with TCA 50 percent solution, once monthly and for maximum of 5 months, second group were treated with CO2 laser that was performed for only one time. Patients were followed at 3 months and 6 months after starting treatment. The improvement of scar was graded by 6-point scale using digital camera and the collected data were analyzed using SPSS software and t, Wilcoxon and Mann-Whitney tests.Results: In this study that 74 females and 18 males were followed, the improvement of scar was 48.13% in the TCA group and 44.87% in the CO2 laser group. This difference was not statistically significant (P=0.55). There was also no significant difference regarding side effects between these 2 groups. Conclusion: The results of our study showed efficacy of topical treatment with 50 percent TCA solution is comparable with CO2 laser in the treatment of leishmaniasis scar. Because of the low cost and simple application of TCA solution in comparison with CO2 laser, we suggest the use of this treatment for correction of leishmaniasis or atrophic scars.
Nilforoushzadeh Mohammad Ali; Haftbaradaran Elaheh; Siadat Amir Hossein
Volume 10, Issue 3 , 2007, , Pages 240-244
Abstract
Cutaneous leishmaniasis is an endemic disease in Iran and there is no curative treatment. The disfiguring scar that remains after it subsides is a major psychologic and emotional problem in these patients. Chronic leishmaniasis is a rare form of this malady which is seen in 5-7 percent of cases. In this ...
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Cutaneous leishmaniasis is an endemic disease in Iran and there is no curative treatment. The disfiguring scar that remains after it subsides is a major psychologic and emotional problem in these patients. Chronic leishmaniasis is a rare form of this malady which is seen in 5-7 percent of cases. In this article we report a 46-year-old man who was refered to us for a large leishmaniasis lesion consisting of a scaling erythematous plaque with several papules on the right side of face and nose. This patient was treated by a combination of systemic Glucantime, 50% trichlroacetic acid and oral fluconazole. Complete resolution was achieved after 4 months.
Giti Sadeghian; Masoomeh Sadeghi
Volume 10, Issue 1 , 2007, , Pages 9-12
Abstract
Background and aim: Antimonial compounds are regarded as the treatment of choice for cutaneous leishmaniasis (CL). Systemic administration of these drugs have some side effects such as cardiotoxicity. The objective of this study was to evaluate the electrocardiographic (ECG) changes in patients with ...
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Background and aim: Antimonial compounds are regarded as the treatment of choice for cutaneous leishmaniasis (CL). Systemic administration of these drugs have some side effects such as cardiotoxicity. The objective of this study was to evaluate the electrocardiographic (ECG) changes in patients with CL treated with systemic Glucantime.Materials and methods: This study with simple sampling method was done on patients with CL who had indication for treatment with systemic Glucantime. Before and during the treatment (weekly) and 1 month after stopping the treatment ECGs were taken from patients. The patients with baseline abnormal ECG were not included in the study.Results: 131 patients were enrolled in this study. The most common change was prolonged QT interval that was seen in 19% of patients. ST depression occurred in 6.1% and minimal ST elevation occurred in 3%, inverted T was observed in 7.4% of patients. Single PAC and single PVC occurred in 0.7% and 2.29%, respectively. Also we observed bradycardia in 10.6% and left bundle branch block in 0.7% of the patients. All of these changes reversed 1 month after treatment except for left bundle branch block.Conclusion: Important ECG changes are minimal in CL patients with normal baseline ECG treated with Glucantime and its administration seems to be safe.
Layegh Pouran; Panah Mohammad Javad Yazdan; Dadkhah Seyed Masoud; Shakeri Mohammad Taqi; Vosough Elham Mohammadi
Volume 9, Issue 4 , 2006, , Pages 303-307
Abstract
Background and aim: Complications and resistance to pentavalent antimonial agents in cutaneous leishmaniasis, exhibit the need for effective alternative drugs. The aim of this study was to compare the efficacy of oral azithromycin with systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous ...
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Background and aim: Complications and resistance to pentavalent antimonial agents in cutaneous leishmaniasis, exhibit the need for effective alternative drugs. The aim of this study was to compare the efficacy of oral azithromycin with systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. Materials and Methods: Forty-seven patients with cutaneous leishmaniasis visited at the dermatology department of Qaem hospital were randomly divided to two groups. Twenty patients (with 29 lesions) were treated with oral azithromycin 500 mg/day for 5 successive days each month for 4 months and 27 patients (with 58 lesions) were treated with systemic Glucantime 60 mg/kg/day for 20 days. Azithromycin group patients were visited monthly and control group patients were visited in last day of treatment and 45 days later. Results:At the end of our study 10.3% of lesions in azithromycin group showed complete response, 27.6% lesions partial response and 62.1% no response. In Glucantime group 34.5% of lesions showed complete response, 13.8% partial response and 51.7% no response (P=0.036).Conclusion: In treatment of cutaneous leishmaniasis systemic Glucantime is superior to oral azithromycin. Differences between our result and previous studies may be due to difference between strains of Leishmanias and in vitro studies may be necessary to resolve this paradox. On the other hand, change in dosage and course of treatment with azithromycin may affect the efficacy of this agent.
F Jafari; Sh Moradi; MA Nilforoush Zadeh; R Derakhshan; N Ansari
Volume 9, Issue 3 , 2006, , Pages 211-216
Abstract
Background and aim: Cutaneous leishmaniasis is an endemic disease in Iran. Although there are many different treatments for this disease, there is not any effective treatment yet. Since there has been a number of different reports on the effectiveness of Cassia fistula plant in the treatment of leishmaniasis, ...
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Background and aim: Cutaneous leishmaniasis is an endemic disease in Iran. Although there are many different treatments for this disease, there is not any effective treatment yet. Since there has been a number of different reports on the effectiveness of Cassia fistula plant in the treatment of leishmaniasis, the efficacy of concentrated boiled extract and hydro alcoholic extract of Cassia fistula on the leishmaniasis disease was compared with intralesional injection of Glucantime in this study.Materials and Methods: In this randomized clinical trial a total of 165 patients, 6 to 60 years old, who had a positive leishmania smear refered to the Isfahan Skin and Leishmaniasis Research Center were divided into three groups using list of random numbers and were treated with: concentrated boiled extract of Cassia fistula, hydroalcholic extract of Cassia fistula, or intralesional injection of Glucantime. The patients were treated for 4 weeks and followed for three months after the study started. The efficacy of treatment was reported as complete cure, partial improvement and no improvement on the basis of clinical and parasitological evidence.Results: In the present study 63/6% of patients treated with the concentrated boiled extract, 52/7% of the hydroalcoholic extract and 45/5% of the Glucantime group were men. 22 patients (40%) of the concentrated boiled extract of Cassia fistula, 20 pateints (36/4%) of the hydroalcoholic extract of Cassia fistula group and 36 patients (65/5%) of the Glucantime group showed complete cure. The efficacy in the third group was much more than the first (P<0.02) and second groups (P<0.005), but there was not any difference between concentrated boiled extract and hydroalcoholic extract of Cassia fistula.Conclusion: The results of this study showed that this plant might be used topically along with Glucantime for decreasing the time and dose of treatment with Glucantime.
MA Nilforoush Zadeh; Sh Moradi; R Derakhshan; E Haft Baradaran; F Jafari
Volume 9, Issue 3 , 2006, , Pages 221-226
Abstract
Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we ...
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Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we assessed the efficacy of honey in acute CL.Materials and Methods: In a randomized clinical trial, 100 patients with CL referred to Skin and Leishmaniasis Research Center were treated with either weekly intra-lesional injection of Glucantime alone or combined with twice daily topical application of honey. The patients were evaluated clinically 2 ,3 and 4 months after treatment.Results: Ninety patients completed the study, forty-five patients were treated in each group. At the end of trial, 32 patients (71/1%) of these treated with Glucantime alone and 23 patients (51/1%) treated with honey were cured (P=0.04).Conclusion: Drug interference and inhibition of bioavailability of Glucantime by honey may decrease the efficacy of Glucantime in treatment of CL.
M Maleki; Z Javidi; V Mashayekhi; MT Shakeri; Y Nahidi; MA Hamed Shojaei; M Hanifeh Zadeh
Volume 9, Issue 2 , 2006, , Pages 132-138
Abstract
Background and aim: In spite of the existance of different types of treatment for cutaneous leishmaniasis, an efficient, safe and cheap treatment has not been found yet. There are some studies showing antiparasiticidal effect of direct current electricity both in vivo and in vitro. The objective of this ...
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Background and aim: In spite of the existance of different types of treatment for cutaneous leishmaniasis, an efficient, safe and cheap treatment has not been found yet. There are some studies showing antiparasiticidal effect of direct current electricity both in vivo and in vitro. The objective of this study was to evaluate the effect of electrotherapy in treatment of cutaneous leishmaniasis.Materials and Methods: This trial was done on 16 patients referred to dermatology clinics of Mashhad University of Medical Sciences with cutaneous leishmaniasis. Twenty-seven lesions were treated in six weekly sessions for 10 minutes, by direct current electricity. The intensity ranged from 5 to 15 mA, and the voltage was kept below 40 volts. Ten lesions were left untreated as control group. At each session the size of induration was measured and recorded.Results: At the end of the trial, in the study group, the average of the induration size decreased 55±30% , however, in the control group the induration size increased 20±20% (P<0.05).Conclusion: Direct current electricity was effective in the treatment of cutaneous leishmaniasis to some extent. Further studies with alteration in method of this treatment are needed.
G Sadeghian; MA Nilforoush Zadeh
Volume 9, Issue 1 , 2006, , Pages 17-21
MA Nilfroush Zadeh; N Anasri; R Derakhshan
Volume 8, Issue 6 , 2006, , Pages 457-461
Abstract
Background and aim: Pentavalent antimony compounds are the first line treatment for cutaneous leishmaniasis. Clinical resistance to pentavalent antimony in the form of meglumine antimoniate (Glucantime) has been recognized as a problem in leishmaniasis. Herein, clinical response to Glucantime were studied ...
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Background and aim: Pentavalent antimony compounds are the first line treatment for cutaneous leishmaniasis. Clinical resistance to pentavalent antimony in the form of meglumine antimoniate (Glucantime) has been recognized as a problem in leishmaniasis. Herein, clinical response to Glucantime were studied in patients suffered from cutaneous leishmaniasis.Materials and Methods: In a cross-sectional study 370 patients with cutaneous leishmaniasis were treated with systemic Glucantime, 50 mg/kg/day, for 2 to 3 weeks. They were visited weekly for 3 weeks and also followed up for 3 months after treatment was completed. The clinical and parasitological response to this treatment was evaluated, and classified into partial and complete response and failure to treatment. Results: Two hundred forty-seven men and 123 women were followed up. The mean age was 36.7±16 years. There were 64.1% partial response after 2 weeks and 73% partial response at the third week of treatment. 11.6% of lesions were not cured after 3 weeks of treatment and 8.1% were not still cured 12 weeks thereafter.Conclusion: Clinical resistance to Glucantime is an important problem. The mechanisms of resistance and using drug combinations are needed to be considered.
MA Nilforoush Zadeh; F Jafari; N Ansari; Z Nilforoushan; AR Firooz
Volume 8, Issue 5 , 2005, , Pages 340-346
P Layegh; M Ebrahimi Rad; K Ghafar Zadegan
Volume 8, suppl , 2005, , Pages 5-9
Abstract
Porokeratosis of Mibelli is a keratinization disorder due to cellular clones that show different degress of dysplasia. Sometimes, these lesions develop on the previously traumatized or burnt skin. Herein, a 24 – year- old female patient is presented with three facial skin lesions on her right cheek ...
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Porokeratosis of Mibelli is a keratinization disorder due to cellular clones that show different degress of dysplasia. Sometimes, these lesions develop on the previously traumatized or burnt skin. Herein, a 24 – year- old female patient is presented with three facial skin lesions on her right cheek on a previous old scar due to cutaneous leishmaniasis is presented. The larger lesion was an erythematosquamous plaque with a well – defined hyperkeratotic margin and an atrophic center and two smaller erythematosquamous papules were located about 1.5 centimeter away from the main lesion. In the histopathologic evaluation of the skin biopsy of the patient, hyerkeratosis, irregular acanthosis and the characteristic column of parakeratotic cells (cornoid lamella) were evident. Considering clinical appearance of the lesion as well as the histopathologic findings, the patients was diagnosed as case of porokeratosis of Mibelli that was developed on an old scar due to cutaneous leishmaniasis.
G Sadeghian; MA Nilforoush Zadeh; M Motevali Emami
Volume 8, Issue 4 , 2005, , Pages 251-255
Abstract
Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find ...
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Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find a more effective and safer drug is continuing. The objective of this study was to compare the effect of intra-lesional hypertonic sodium chloride solution and intra-lesional meglumine antimoniate injections in the treatment of cutaneous leishmaniasis.Materials and Methods: This randomized controlled clinical trial with simple sampling method was performed on 72 patients with cutaneous leishmaniasis. The patients were randomly divided in two groups. One group was treated with intra-lesional hypertonic sodium chloride solution and the other one was treated with intra-lesional meglumine antimoniate injections at weekly intervals for 6 to 10 weeks. All patients were followed for 6 months after treatment.Results: After six weeks of treatment, complete improvement, partial improvement, and no response to treatment were 33.3%, 45% and 22% in meglumine antimoniate group and 26%, 23% and 51% in trial group, respectively. In both groups complete improvement was observed in lesions smaller than 2 cm². In lesions with partial improvement the treatment was continued up to 10 weeks and all patients were followed for six months. After six months ultimate cure rate was 52% in meglumine antimoniate group and 25% in hypertonic sodium chloride solution group.Conclusion: Injections of hypertonic sodium chloride solution has less efficacy in comparison with intra-lesional meglumine antimoniate in treatment of cutaneous leishmaniasis, but considering the good response in primary small lesions, it can be used as an alternative therapy in some special cases including small lesions and allergic reactions to meglumine antimoniate.
SZ Famili; F Pezeshk Poor; V Sepehr; M Vahedian
Volume 8, Issue 2 , 2005, , Pages 97-100
Abstract
Background: Cutaneous leishmaniasis is an important skin parasitic disease. Ideal treatment is not found yet and seeking for proper drugs continues. Objective: Comparison of the efficacy of fluconazole with systemic glucantime in patients with acute cutaneous leishmaniasis in Ghaem hospital in Mashhad ...
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Background: Cutaneous leishmaniasis is an important skin parasitic disease. Ideal treatment is not found yet and seeking for proper drugs continues. Objective: Comparison of the efficacy of fluconazole with systemic glucantime in patients with acute cutaneous leishmaniasis in Ghaem hospital in Mashhad in 2002. Patients and Methods: During one year of study, all patients with cutaneous leishmaniasis were divided to two group. Thirty-one patients were treated with oral fluconazole (100 mg twice a day) for 6 weeks and 29 patients were treated with intra-muscular glucantime (20 mgSb/kg) for 21 days. Both groups were evaluated 3 and 6 weeks after onset of treatment. T-test and Chi-square test were used for statistical analyses and (P0.05). Conclusion: It seems that efficacy of fluconazole in acute cutaneous leishmaniasis is lower than glucantime. A larger clinical trial is recommended.
G Sadeghian; F Iraji; MA Nilforoosh Zadeh
Volume 8, suppl , 2004, , Pages 31-34
Abstract
Cutaneous leishmaniasis (CL) is a parasitic disease, which is hyperendemic in Isfahan, usually caused by L.major and L.tropica. Herein we report a patient with post-mastectomy lymphedema on right upper limb accompanying with the lesions of cutaneous leishmaniasis on the right and left forearms. Following ...
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Cutaneous leishmaniasis (CL) is a parasitic disease, which is hyperendemic in Isfahan, usually caused by L.major and L.tropica. Herein we report a patient with post-mastectomy lymphedema on right upper limb accompanying with the lesions of cutaneous leishmaniasis on the right and left forearms. Following radiotherapy, the lesions on the limb with lymphedema were disseminated. But the lesions on left side showed no change. This finding may be the result of immune disorder due lymphedema and radiotherapy.
AR Firooz; AR Khatami; A Khamesipour; M Nassiri Kashani; MA Nilforoushzadeh; F Behnia; HR Pazoki Toroudi; Y Dowlati
Volume 7, Issue 4 , 2004, , Pages 209-218
Abstract
Background: Several treatment modalities have been used for cutaneous leishmaniasis (CL) with various results. In vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnSO4) on Leishmania parasites. Objective: To compare the efficacy of intralesional injections of 2% ZnSO4 solution ...
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Background: Several treatment modalities have been used for cutaneous leishmaniasis (CL) with various results. In vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnSO4) on Leishmania parasites. Objective: To compare the efficacy of intralesional injections of 2% ZnSO4 solution with meglumine antimonate (Glucantime) in the treatment of acute Old World CL. Patients and Methods: Seventy-two patients with CL with a duration of less than 8 weeks were recruited in a randomized, double-blind, clinical trial in Isfahan province – an area endemic for Leishmania major – after giving written informed consent. They were treated with 6 weekly intralesional injections of either 2% sterile ZnSO4 solution or Glucantime prepared in identical vials. The primary outcome measure was complete re-epithelialization of CL lesions. Results: Among 36 patients with 53 lesions treated with ZnSO4 and 36 patients with 53 lesions treated with Glucantime, 13 patients with 19 lesions and 22 patients with 31 lesions completed the trial, respectively. Inadequacy of treatment was the main reason for drop-out in 12 (33.3%) and 2 (5.5%) patients in ZnSO4 and Glucantime groups, respectively (P<0.05). Complete re-epithelialization was observed in 2 (10.5%) and 19 (61.3%) lesions 1 week after the end of treatment in the ZnSO4 and Glucantime groups, respectively (P<0.05). Conclusion: A six-week course of weekly intralesional injections of 2% ZnSO4 solution was less effective than Glucantime in the treatment of acute Old World CL.
MH Aziz Jalali; H Ansarin; S Mirzazadeh Javaheri
Volume 7, Issue 3 , 2004, , Pages 192-194
Abstract
Basal cell carcinoma (BCC) is the most common malignant tumor of the skin, which originates from the basal cell layer of the skin. It is more common in white race with skin types I and II. Some predisposing factors are sunlight, ionizing radiation, arsenic salts, PUVA and scar. We present a case of BCC, ...
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Basal cell carcinoma (BCC) is the most common malignant tumor of the skin, which originates from the basal cell layer of the skin. It is more common in white race with skin types I and II. Some predisposing factors are sunlight, ionizing radiation, arsenic salts, PUVA and scar. We present a case of BCC, which appeared over an old scar of localized cutaneous leishmaniasis in a 49-year-old woman.
MA Nilforoosh Zadeh; T Jalayer; B Ataei; F Jafari; M Motavali Emami
Volume 7, Issue 2 , 2004, , Pages 78-83
Abstract
Background: Humans, rodents and sandflies have role in transmitted cycle of cutaneous leishmaniasis. To control the disease, promoting the environment, killing the rodent and poisoning the vectors are recommended, individually all over the world. Since, there is no effective vaccine against this disease, ...
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Background: Humans, rodents and sandflies have role in transmitted cycle of cutaneous leishmaniasis. To control the disease, promoting the environment, killing the rodent and poisoning the vectors are recommended, individually all over the world. Since, there is no effective vaccine against this disease, the integration of methods is considerable. Objective: To evaluate the efficacy of integration method in the control of cutaneous leishmaniasis. Patients and Methods: This study was an interventional study, which after knowing the ecosystem around the Imamzadeh Agha Ali Abbas in Natanz in Isfahan, perform the plat covering within a radius of 100m, entrances correction, pool and garbage storage removal and sweepings for the rodents within a radius of 2kms around the Imamzadeh and poisoning the vectors have been done. Results: The incidence of disease was 3.7% in 1996 (Before intervention), which was decreased to 1/17 in 1996 and to 1/12 a year later. Conclusion: Integration method consisting of environment improvement, rodents removal and poisoning as well as training high risk people is recommended to control cutaneous leishmaniasis.
M Mohebali; P Yaghoobi; B Hooshmand; A Khamesipour
Volume 7, Issue 2 , 2004, , Pages 88-94
Abstract
Background: Considering the difficulties, adverse effects and unsuitable response to commonly used drugs; it is essential to find an alternative, particularly local treatment for cutaneous leishmaniasis (CL). Objective: Determination of efficacy of topical paromomycin (Paromo-U ointment) against CL caused ...
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Background: Considering the difficulties, adverse effects and unsuitable response to commonly used drugs; it is essential to find an alternative, particularly local treatment for cutaneous leishmaniasis (CL). Objective: Determination of efficacy of topical paromomycin (Paromo-U ointment) against CL caused by L.major in mouse model. Materials and Methods: Skin lesions were created 1 to 3 months after inoculation of L.major promastigotes to the base of tail of small, white mice (Outbreed). Then the mice were randomly divided to three groups including interventional (Treatment by Paromo-U), control 1 (Treatment by urea) and control 2 (Treatment by distilled water) groups. The mice were treated topically twice a day for 8 weeks. Results: The mean lesion diameter of the lesions prior to treatment in interventional and control groups (Urea and distilled water) were measured 10.9, 5.9 and 6.0 mm respectively and changed to 4.0, 12.7 and 14.3 mm 8 weeks after treatment. No Leishman bodies were observed within the lesions of interventional group, whereas they were seen in all control groups. Conclusion: Paromo-U ointment was effective in the treatment CL caused by L.major in mouse model.
MJ Yazdan Panah; SK Mostoufi; M Soleimani
Volume 6, Issue 2 , 2003, , Pages 20-24
Abstract
Background: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis (CL), but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance, adverse effects and low compliance of patient, ...
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Background: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis (CL), but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance, adverse effects and low compliance of patient, efforts for finding a more effective and safer drug continue. Objectives: To evaluate the efficacy of oral zinc sulfate in the treatment of acute dry CL. Patients and Methods: 31 patients with clinical diagnosis of acute, dry CL and positive direct smear for Leishman bodies were included in the trial. Patients were treated with 10 mg/kg/day oral zinc sulfate for 45 days and evaluated every 3 weeks during the period of treatment and also 1.5 months after cessation of it. Results: 22 patients completed the course of treatment. At the end of 45 days of treatment, only two cases (9%) were cured and the remaining did not show satisfactory response. Conclusion: Oral zinc sulfate has limited therapeutic value in the treatment of dry CL.
A Asilian; A Sadeghinia; F Shariati; SM Emam Jome; AR Ghoddusi
Volume 6, Issue 2 , 2003, , Pages 25-29
Abstract
Background: Some researchers claim that permethrin-impregnated clothes are effective in the prevention of cutaneous leishmaniasis. Objectives: To determine the effectiveness of permethrin-impregnated clothes in the prevention of cutaneous leishmaniasis. Patients and Methods: 272 soldiers were randomized ...
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Background: Some researchers claim that permethrin-impregnated clothes are effective in the prevention of cutaneous leishmaniasis. Objectives: To determine the effectiveness of permethrin-impregnated clothes in the prevention of cutaneous leishmaniasis. Patients and Methods: 272 soldiers were randomized in two groups. In one group permethrin-impregnated clothes and in the other group, control clothes were used. In each group the clothes were worn during days and nights for three months and the soldiers were followed for additional 6 months. Results: 9 (6.5%) of 138 soldiers wearing control clothes and 6 (4.4%) of 134 soldiers wearing permethrin-impregnated clothes acquired cutaneous leishmaniasis. The difference between two groups was not statistically significant. Conclusion: Permethrin-impregnated clothes are not effective in the prevention of cutaneous leishmaniasis.