We report of a 29-year-old man presented with yellow-red, scaling papules on the skin of scalp, retro-auricular folds, inguinal, axillary, chest and abdomen. The lesions had a poikilodermatious appearance in some areas, such as trunk. The patient also had diabetes insipidus and skull osteolytic lesions. The diagnosis of langerhans cell histiocytosis (LCH) was suggested based on H and E staining of skin biopsy specimen. S-100 staining was positive in immunohistochemistry. Birbeck granules were seen in electron microscopic examination confirming the diagnosis of LCH. Considering the systemic involvement, he is a case of an extensive LCH in new classification and a case of Hand-Schuller-Christian in the old classification. The cutaneous lesions of the patients responded to oral thalidomide 200 mg daily after 2 months and did not recur after 6 months follow up.
Mortazavi,H. , Ehsani,A. , Safaei Naraghi,Z. and Asgari,M. (2001). Langerhans cell Histiocytosis: Report of a case with cutaneous lesions with favorable response to oral Thalidomide. Iranian Journal of Dermatology, 4(4), 34-40.
MLA
Mortazavi,H. , , Ehsani,A. , , Safaei Naraghi,Z. , and Asgari,M. . "Langerhans cell Histiocytosis: Report of a case with cutaneous lesions with favorable response to oral Thalidomide", Iranian Journal of Dermatology, 4, 4, 2001, 34-40.
HARVARD
Mortazavi H., Ehsani A., Safaei Naraghi Z., Asgari M. (2001). 'Langerhans cell Histiocytosis: Report of a case with cutaneous lesions with favorable response to oral Thalidomide', Iranian Journal of Dermatology, 4(4), pp. 34-40.
CHICAGO
H. Mortazavi, A. Ehsani, Z. Safaei Naraghi and M. Asgari, "Langerhans cell Histiocytosis: Report of a case with cutaneous lesions with favorable response to oral Thalidomide," Iranian Journal of Dermatology, 4 4 (2001): 34-40,
VANCOUVER
Mortazavi H., Ehsani A., Safaei Naraghi Z., Asgari M. Langerhans cell Histiocytosis: Report of a case with cutaneous lesions with favorable response to oral Thalidomide. Iran J Dermatol, 2001; 4(4): 34-40.
