Original Article
Nassiri Soheila; Saffarian Zahra; Younespour Shima
Volume 16, Issue 1 , 2013, Pages 1-5
Abstract
Background: Alopecia areata (AA) is an autoimmune disorder ofhair follicles. We aimed to find the association between VitaminD level and AA.Method: Eligible AA patients and controls were enrolled inthis case-control study and serum samples were assessed for25-hydroxy vitamin D (25-(OH)-D3). The levels ...
Read More
Background: Alopecia areata (AA) is an autoimmune disorder ofhair follicles. We aimed to find the association between VitaminD level and AA.Method: Eligible AA patients and controls were enrolled inthis case-control study and serum samples were assessed for25-hydroxy vitamin D (25-(OH)-D3). The levels of 25-(OH)-D3were categorized as deficient (<10ng/ml), insufficient (10 to<30 mg/ml) and sufficient (>30ng/dl) and the SALT (Severityof Alopecia Tool) score was used to assess the severity of thedisease. The data was analysed and the association betweenvitamin D levels and AA, disease distribution, and the patternof hair loss was investigated.Result: Twenty eight patients (19 males, 9 females) and 44healthy controls (16 males, 28 females) were assessed. Therewas no statistically significant difference between patients andcontrols with regard to the level of 25(OH)D3 when the data wasadjusted for gender (Ordinal odds ratio: 0.49 (0.18-1.34 and 95%CI, p-value=0.16). The level of 25(OH)D3 was lower in patientswith nail involvement in contrast to those without it (P=0.02);moreover, no significant difference was found between patientswith different patterns of hair loss.Conclusion: After adjustment for gender, there was no associationbetween AA and the level of vitamin D.
Original Article
Farhad Handjani; Nasrin Saki; Bahareh Kardeh; Masoomeh Maghsoodi
Volume 16, Issue 1 , 2013, Pages 6-8
Abstract
Background: Hirsutism is defined as the presence of terminalhairs with a male-like pattern in women, due to the increasedlevels of androgens or increased responses of the target organs toandrogens. Facial hirsutism has a negative effect on the quality oflife in female patients. Among the many therapeutic ...
Read More
Background: Hirsutism is defined as the presence of terminalhairs with a male-like pattern in women, due to the increasedlevels of androgens or increased responses of the target organs toandrogens. Facial hirsutism has a negative effect on the quality oflife in female patients. Among the many therapeutic modalitiesfor hirsutism, laser therapy is of great acceptability. The longpulse Alexandrite laser, diode laser, and Nd:YAG laser are themost commonly used lasers in the treatment of hirsutism. In thisstudy, we assessed the effect of laser therapy on the quality oflife of the patients with hirsutism, using the Dermatology LifeQuality Index (DLQI) and Visual Analog Scale (VAS).Method: Forty-two female patients with idiopathic hirsutism,ranging from 18 to 34 years old, were studied during a courseof laser therapy lasting for at least 4 months for up to 3 courses.Each patient completed a DLQI and VAS questionnaire beforeand after treatment. The VAS questionnaire was also filled outby the dermatologist.Result: Following laser therapy, the average DLQI score,decreased by 10 points (a statistically significant difference withp- value<0.001). VAS also declined and there was a moderate togood correlation between the VAS scores given by the patientand the dermatologist.Conclusion: This study demonstrated that laser therapy improvedthe quality of life in patients with hirsutism.
Original Article
Mohammad Shahidi-Dadras; Parviz Toossi; Reza Jafari Fesharaki; Azin Ayatollahi; Mehdi Qeisari; Shima Younespour
Volume 16, Issue 1 , 2013, Pages 9-12
Abstract
Background: To our knowledge, there is a hypothesis regardingthe association of vitiligo with other autoimmune disorders.Organ-specific autoantibodies are found more frequently in theserum of vitiligo patients. Recent studies have demonstratedthe role of alterations in serum transforming growth factor-beta(TGF-beta) ...
Read More
Background: To our knowledge, there is a hypothesis regardingthe association of vitiligo with other autoimmune disorders.Organ-specific autoantibodies are found more frequently in theserum of vitiligo patients. Recent studies have demonstratedthe role of alterations in serum transforming growth factor-beta(TGF-beta) released from regulatory T cells in the pathogenesisof depigmentation observed in vitiligo. It has been shown that incomparison with patients without autoimmune diseases, serumTGF-beta levels increase in patients whose vitiligo is associatedwith autoimmune diseases. We hypothesized a relationshipbetween serum TGF-beta levels and organ-specific autoantibodiesthat could predict other autoimmune diseases in vitiligo patients.Method: Forty-five patients with a mean age of 35.96±13.34years who had stable vitiligo since 1 year ago and involvementof up to 30% body surface area were enrolled. Organ-specificautoantibodies (ANA, anti mitochondrial Ab, anti TPO (antithyroid microsomal Ab), anti parietal cell Ab, anti thyroglobulinAb) and serum TGF-beta level were evaluated.Result: Twenty-three patients (51.11%) had at least one positiveorgan-specific autoantibody. Anti TPO in 16 patients, antithyroglobulin Ab in 9 patients, anti parietal cell Ab and ANAeach in 5 patients, and anti mitochondrial Ab in 4 patients werepositive. Mean serum TGF-beta level was 105.82±30.33; there wasno significant difference in serum TGF-b level between patientswith and without positive organ-specific autoantibody (P=0.26).Conclusion: Although another study showed the relationshipbetween serum TGF-beta levels and autoimmune disordersin vitiligo patients, we did not find a significant difference inserum TGF-beta levels in these patients regarding the positivityof organ-specific antibodies. It may be due to the fact that ourpatients had autoantibodies without clinical autoimmune diseaseexcept vitiligo.
Original Article
Emad Maryam; Moezzi Jafar; Dastgheib Ladan
Volume 16, Issue 1 , 2013, Pages 13-5
Abstract
Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been ...
Read More
Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been thestandard treatment.Method: The study was an open clinical trial with a split-facedesign. All patients applied hydroquinone 4% cream on theright side and azelaic acid 20% cream on the left side for 20weeks. Modified melasma area and severity index (mMASI) wasdetermined for each patient at the beginning and at the end ofstudy and compared statistically.Result: Thirty-three patients were included in the study. Althoughboth medications were effective in reducing mMASI, there wasno statistical difference between the two (P value=0.6). Overall,69.7% of the patients on the hydroquinone 4% side and 63.6%on the azelaic acid 20% side showed good to excellent response.The subjective patient assessment of improvement was 75.7% forhydroquinone 4% and 66.6% for azelaic acid 20%.Conclusion: Both topical hydroquinone 4% and topical azelaicacid 20% had almost similar effects. Considering the relativelyless known side effects of azelaic acid compared to hydroquinone,it can be an appropriate substitute in the treatment of melasma.
Original Article
Mohammad Radmanesh; Ramin Radmanesh
Volume 16, Issue 1 , 2013, Pages 17-20
Abstract
Background: Although cryotherapy has been reported as atechnique for depigmenting residual pigmented patches inpatients with universal vitiligo, Q-switched Nd-YAG lasershave not yet been used for this purpose. The aim of this studywas to compare the efficacy of cryotherapy with that of 532nmQ-switched ...
Read More
Background: Although cryotherapy has been reported as atechnique for depigmenting residual pigmented patches inpatients with universal vitiligo, Q-switched Nd-YAG lasershave not yet been used for this purpose. The aim of this studywas to compare the efficacy of cryotherapy with that of 532nmQ-switched Nd-YAG laser therapy for depigmentation in patientswith universal vitiligo.Method: Six adult patients (4 male and 2 female) with universalvitiligo and facial residual pigmented patches were treatedsimultaneously with cryotherapy on the right and the frequencydoubled532nm Q-switched Nd-YAG laser therapy on the leftside. The laser parameters used were spot size 3-5mm, frequencyrate 10 hertz, and the fluence was 5J/cm2. The cryo system wasa closed contact CO2 Cryo gun. The patients were scheduled tobe treated monthly.Result: The depigmentation was complete after three successivesessions of cryotherapy and 30-45 days after the last session, incomparison with simultaneous 30-70% depigmentation of the laserside. No scar or permanent sequellae developed on either side.Conclusion: Cryotherapy is more effective and fast-actingthan Q-switched Nd-YAG laser for depigmentation of residualpigmented patches in patients with universal vitiligo.
Original Article
Razavi Mohammad Seyed Mansour; Saghafinia Masoud; Davoudi Seyed Masoud; Salamati Payman
Volume 16, Issue 1 , 2013, Pages 21-30
Abstract
Background: The skin is among the main tissues affected bySulfur Mustard (SM) in chemical attacks. Iranian researchershave performed extensive studies on the exposed victims andhave reported a wide spectrum of information in this field. Themain objective of this study was to develop a comprehensiverevision ...
Read More
Background: The skin is among the main tissues affected bySulfur Mustard (SM) in chemical attacks. Iranian researchershave performed extensive studies on the exposed victims andhave reported a wide spectrum of information in this field. Themain objective of this study was to develop a comprehensiverevision of data on the pathology, pathogenesis, clinical findings,complications, and treatment of sulfur mustard exposure.Method: This study was part of a systematic search whichincluded all the war related studies on Iranian victims. Amongnearly 300 retrieved articles, a total of 193 medical articles wereapproved in terms of quality and were related to the Iraq-Iranchemical war (1984-1988) out of which 48 were directly relatedto the dermatologic effects of sulfur mustard. We used knowninternational databases such as ISI, Medline, Scopus, and Iraniandatabases such as Iranmedex, SID, and Irandoc in this study.Publishing the articles in approved journals was the main criterionfor their quality.Result: In this study, the most common symptom in the delayedphase of the exposure to SM was itching which was more frequentlyseen in women as compared to men. The most common sign waserythema in the skin. One of the chronic complications at thesite of exposure was mustard scar. Lipoma and cherry angiomawere the most common skin tumors which were reported.Iranian researchers have presented different approaches for themanagement of exposed victims.Conclusion: In this study, in addition to the effects of SM onthe skin, some methods were presented for decontamination,management of itching, vesicles, blisters and treatment of chronicskin lesions.
Case Report
Mahmoud Farshchian; Mehrdokht Mazdeh; Hamidreza Ghasemi Basir; Mohammadreza Sobhan
Volume 16, Issue 1 , 2013, Pages 31-35
Abstract
Primary cutaneous large B-cell lymphoma leg type is a rare andaggressive neoplasm as defined by the recently updated WorldHealth Organization - European Organization for Research andTreatment of Cancer. We report a case of an 80-year-old manwith multiple cutaneous lesions. Here, we review the availableliterature ...
Read More
Primary cutaneous large B-cell lymphoma leg type is a rare andaggressive neoplasm as defined by the recently updated WorldHealth Organization - European Organization for Research andTreatment of Cancer. We report a case of an 80-year-old manwith multiple cutaneous lesions. Here, we review the availableliterature and summarize clinical features and management ofthis type of cutaneous B-cell lymphoma.
Case Report
Hadiuzzaman M
Volume 16, Issue 1 , 2013, Pages 36-38
Abstract
Aplasia cutis congenita is the congenital absence of skin mostcommonly affecting the scalp. No definite etiology is available butmultiple causes such as intrauterine infection, fetal exposure tococaine, heroin, alcohol or antithyroid drugs, vascular disruption,genetic causes, syndromes and teratogens ...
Read More
Aplasia cutis congenita is the congenital absence of skin mostcommonly affecting the scalp. No definite etiology is available butmultiple causes such as intrauterine infection, fetal exposure tococaine, heroin, alcohol or antithyroid drugs, vascular disruption,genetic causes, syndromes and teratogens have been suggested.We present an infant with extensive aplasia cutis of the trunk andthigh. He was the third child of his parents while the outcomeof the first and the second pregnancy was intrauterine death;the dead fetuses however had no skin anomaly.
Case Report
Falguni Nag; Saugato Biswas; Trupti Surana; Arghyaprasun Ghosh; Gobinda Chatterjee
Volume 16, Issue 1 , 2013, Pages 39-41
Abstract
Verrucous hemangioma is a rare, localized vascular malformation.The lesions are bluish-red, well demarcated, and compressible. Wereport a case of a 10-year-old girl with coexistent disseminatedverrucous hemangioma and subcutaneous hemangioma overthe nape of neck.
Read More
Verrucous hemangioma is a rare, localized vascular malformation.The lesions are bluish-red, well demarcated, and compressible. Wereport a case of a 10-year-old girl with coexistent disseminatedverrucous hemangioma and subcutaneous hemangioma overthe nape of neck.
Quiz
Banihashemi Mahnaz; Fazel Zahra; Meibodi Naser Tayyebi; Imani Mohammad; Zabolinejad Naghmeh
Volume 16, Issue 1 , 2013, Pages 42-44
Abstract
A 38- year-old man in good general health and normal intellectualfunctioning referred to the dermatologic clinic with numerouspruritic reticulate pigmentations on his neck, chest and upperback since 10 years ago. We noticed similar lesions on his axillae,groin and infra mammary area with no family background.
Read More
A 38- year-old man in good general health and normal intellectualfunctioning referred to the dermatologic clinic with numerouspruritic reticulate pigmentations on his neck, chest and upperback since 10 years ago. We noticed similar lesions on his axillae,groin and infra mammary area with no family background.
