Original Article
Abbasi Ali; Toossi Parviz; Shakoei Safoura; Abolhasani Ehsan; Younespour Shima
Volume 16, Issue 3 , 2013, Pages 83-88
Abstract
Background: Different modalities have been tried in order totreat stable vitiligo. Culturing melanocytes is time consumingand expensive. Therefore, new methods using autologousmelanocytes are sought. We aimed to compare the mixed nonculturedautologous melanocytes of the outer root sheath andthe bulge ...
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Background: Different modalities have been tried in order totreat stable vitiligo. Culturing melanocytes is time consumingand expensive. Therefore, new methods using autologousmelanocytes are sought. We aimed to compare the mixed nonculturedautologous melanocytes of the outer root sheath andthe bulge area of hair follicle transplantation plus dermabrasionwith dermabrasion alone in stable generalized vitiligo patchesrepigmentation.Method: Eight patients with stable generalized vitiligo wererecruited. Two patches were selected and assigned to one of thestudy groups: one was treated with dermabrasion alone, andthe other was treated with dermabrasion and transplantation.Uncultured melanocytes were extracted from the patients’ hairfollicle outer root sheath and bulge. The patches were assessedmonthly for the next six months. The primary outcome was todetermine the percentage changes of the depigmented patchesfrom the baseline.Result: Although the repigmentation changes were statisticallysignificant in transplantation patches, there was only one patchwith good and another with fair pigmentation. Furthermore,seven patches without and one patch with poor pigmentationwere observed as control lesions. The transplanted patchesdemonstrated a significantly better repigmentation rate in contrastto their controls (p=0.03).Conclusion: Although this method is fast and economic, theclinical response was not satisfactory.
Original Article
Ebadi Atyeh; Moravvej Hamideh; Hejazi Somayeh; Younespour Shima; Ghalamkarpour Fariba
Volume 16, Issue 3 , 2013, Pages 89-93
Abstract
Background: Despite great advances in therapeutic regimens,complete repigmentation in vitiligo is still out of reach. The aimof this assay was to study the efficacy and tolerability of repeatedneedling combined with narrowband ultraviolet B (NBUVB)therapy in the treatment of generalized, stable, refractory ...
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Background: Despite great advances in therapeutic regimens,complete repigmentation in vitiligo is still out of reach. The aimof this assay was to study the efficacy and tolerability of repeatedneedling combined with narrowband ultraviolet B (NBUVB)therapy in the treatment of generalized, stable, refractory vitiligo.Method: Twenty-six patients with stable generalized intractablevitiligo were recruited in before/after clinical trial. The patientsreceived needling for selected patches weekly for 12 weeks. Allthe patients received NBUVB phototherapy three times a week.Repigmentation improvement was assessed by two blindedinvestigators at weeks 4, 8 and 12. Tolerability was assessed bya 5-point scale.Result: Twenty-two patients (16 women and 6 men) with a mean(SD) age of 34.41 (12.75) years completed the 12-week therapyperiod. In comparison with the baseline, improvement in themean percentage of repigmentation was 7.10±10.15, 12.95±20.29,and 15.57±17.38 at week 4, 8 and 12 of therapy, respectively.A significant improvement was observed in repigmentationpercentages in the three time points (p
Original Article
Ponnaiyan Deepa; Gomathy L; Anusha JA
Volume 16, Issue 3 , 2013, Pages 94-99
Abstract
Background: Melanin pigmentation of the gingiva occurs in allethnicities. Excessive pigmentation is an esthetic concern thathas increased awareness about depigmentation procedures. Thepurpose of the present study was to correlate the skin color andgender with the intensity and distribution of gingival ...
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Background: Melanin pigmentation of the gingiva occurs in allethnicities. Excessive pigmentation is an esthetic concern thathas increased awareness about depigmentation procedures. Thepurpose of the present study was to correlate the skin color andgender with the intensity and distribution of gingival melaninpigmentation in a group of South Indians for treatment strategies.Method: Two hundred male and female non smoking healthysubjects aged 18-35 years were included. A clinical examinationof gingiva was performed to assess the anatomic distribution ofgingival pigmentation. The intensity of gingival pigmentation andthe phenotype of gingiva were also assessed. Subsequently, theskin color was visually examined and assessed as fair, wheatish,brown, and dark.Result: Six classes of gingival pigmentation were definedbased on the anatomic distribution. Gingival pigmentation wasobse
Original Article
Layegh Pouran; Nahidi Yalda; Malekzadeh Iman; Shakeri Mohammad Taghi
Volume 16, Issue 3 , 2013, Pages 100-104
Abstract
Background: Pemphigus is a rare autoimmune disease causedby autoantibodies against desmoglein. It clinically presents withpainful blisters and erosions on the skin and mucous membranes.Few studies have been conducted on the quality of life inpemphigus patients which have all indicated the strong impactof ...
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Background: Pemphigus is a rare autoimmune disease causedby autoantibodies against desmoglein. It clinically presents withpainful blisters and erosions on the skin and mucous membranes.Few studies have been conducted on the quality of life inpemphigus patients which have all indicated the strong impactof the disease on emotional and physical status of the patients.According to evident differences in the culture and quality oflife between our society and western societies, we assessed thequality of life in patients with pemphigus in the Northeast of Iran.Method: This study was conducted on 78 pemphigus vulgarispatients who were visited or hospitalized in the dermatologyclinics of Qaem and Imam Reza Hospitals in Mashhad, Iran.Data collection was done by the Dermatology Life Quality Index(DLQI) questionnaire in patients with pemphigus vulgaris.Statistical analysis was performed using SPSS 11.5 software withChi-square, T-test and ANOVA statistical tests.Result: The disease had a significant impact on the quality oflife in the majority of patients (31 (39.7%) patients). Hospitalizedand newly diagnosed cases and those receiving higher doses ofsteroid had lower quality of life. The patient’s age, sex, educationlevel, and therapeutic regimen did not have a significant effecton the quality of life.Conclusion: Pemphigus is not just a physical disease and hasvarious aspects. It is responsible for many changes in healthrelatedquality of life in patients. Therefore, we will be successfulin treating this disease only when psychological and social aspectsof pemphigus are considered in addition to clinical improvementof the patients.
Original Article
Balighi Kamran; Soori Tahereh; Fouladi Negar
Volume 16, Issue 3 , 2013, Pages 105-108
Abstract
Background: Mucocutaneous manifestations may occur inevery stage of human immunodeficiency virus (HIV) infection.Some of them may be the first presentations. In this study, weevaluated the prevalence of dermatologic manifestations as thefirst presentations of HIV/AIDS in 25 Iranian patients.Method: In ...
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Background: Mucocutaneous manifestations may occur inevery stage of human immunodeficiency virus (HIV) infection.Some of them may be the first presentations. In this study, weevaluated the prevalence of dermatologic manifestations as thefirst presentations of HIV/AIDS in 25 Iranian patients.Method: In a cross sectional study, we evaluated 25 new casesof HIV infection whose HIV infections were diagnosed duringwork up for their recent dermatological problems. The type ofmucocutaneous manifestations and general information suchas age, sex, risk factors, dermatologic problem duration andeducational level was recorded in a questionnaire.Result: Warts (anogenital and generalized warts) were the mostcommon cutaneous manifestation in new HIV infected patients(36%) followed by psoriasis and cutaneous abscess.Conclusion: Some mucocutaneous diseases such as anogenital orgeneralized warts, psoriasis, and cutaneous abscess may presentas the first manifestation of HIV infection.
Case Report
Parviz Toossi; Somayeh Hejazi; Safoura Shakoei; Zahra Asadi-Kani
Volume 16, Issue 3 , 2013, Pages 109-111
Abstract
Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous blistering disease. Although PV occurs predominantly in adulthood, in the 3rd to 5th decades of life, there have rarely been reports of childhood cases which are often misdiagnosed. It presents as oral blisters ...
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Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous blistering disease. Although PV occurs predominantly in adulthood, in the 3rd to 5th decades of life, there have rarely been reports of childhood cases which are often misdiagnosed. It presents as oral blisters that rupture rapidly and progress to painful erosions. Most patients develop cutaneous flaccid blisters that rupture easily and leave painful erosions, which are slow to heal. These erosions are prone to secondary bacterial infection. Without treatment, the disease is progressive and the mortality rate is about 100%. We report an 8-year-old girl who was referred to our clinic from a pediatric center with mucocutaneous recalcitrant blisters.
Case Report
Siavash Mohammadzadeh Shanehsaz; Roshan Bittar; Abdollah Anis; Silva Ishkhanian
Volume 16, Issue 3 , 2013, Pages 112-115
Abstract
Bullous ichthyosiform erythroderma (BIE) is a rare disorder of keratinization (mutations in either keratin 1 or 10). It typically presents with fragile skin, which gives way to gradual evolutionof hyperkeratosis. Flaccid blisters, peeling, and superficial erosions at sites of minor trauma ...
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Bullous ichthyosiform erythroderma (BIE) is a rare disorder of keratinization (mutations in either keratin 1 or 10). It typically presents with fragile skin, which gives way to gradual evolutionof hyperkeratosis. Flaccid blisters, peeling, and superficial erosions at sites of minor trauma or friction are apparent within the first few hours of life. Yellow-brown, waxy, ridged or corrugatedscales build up in skin creases, sometimes forming spiny (Hystrix) outgrowths. Cobble stone-like keratoses occur at other sites such as the dorsal aspects of the hands and feet and over the trunk.We report an 11-year-old boy with a generalized hyperkeratosis on the neck, trunk, extremities, and scalp.
Quiz
Robati Reza M; Sakoei Safoura; Bidari Farahnaz; Hejazi Somayeh
Volume 16, Issue 3 , 2013, Pages 116-117
Abstract
A 65-year-old woman presented with complaint of unremittingulcer between her breasts from 6 months ago. Initially, it wasmanifested as the development of painless, firm, subcutaneouserythematous nodules that gradually enlarged and evolvedinto a chronic ulcer. She also had a history of mild weight loss.There ...
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A 65-year-old woman presented with complaint of unremittingulcer between her breasts from 6 months ago. Initially, it wasmanifested as the development of painless, firm, subcutaneouserythematous nodules that gradually enlarged and evolvedinto a chronic ulcer. She also had a history of mild weight loss.There was no history of anorexia, fever, cough, hemoptysis, orlocal trauma.On physical examination, a 6 by 4 cm ulcer was noted on heranterior upper chest, between breasts, with a little serousdischarge and a granulation tissue at the base surrounded bydensely erythematous woody margins with some telangiectasia.
Letter to Editor
Toossi Parviz; Esmaili-Azad Mitra; Saeedi Mohammad
Volume 16, Issue 3 , 2013, Pages 118-119
Abstract
Treatment of melasma has remained a hottopic in dermatology because of its resistance totherapy and high recurrence rate. For many yearshydroquinone was the foundation of melasmatreatment, but its use has been limited during theseyears due to a number of adverse events, suchas skin irritation, hyper ...
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Treatment of melasma has remained a hottopic in dermatology because of its resistance totherapy and high recurrence rate. For many yearshydroquinone was the foundation of melasmatreatment, but its use has been limited during theseyears due to a number of adverse events, suchas skin irritation, hyper and hypo pigmentation,nail discoloration, conjunctival melanosis andochronosis. Furthermore hydroquinone is quiteunstable and is quickly oxidized and becomeinactive. So Hydroquinone is gradually beingreplaced by new lightning substances, such as kojicacid, phytic acid, azaleic acid, arbutin, mequinol,aleosin, ascorbic acid, soya proteins, N-acetylglucosamine and licorice. In this study weevaluate the effect of a licorice containing product(lightening serum, LANGE Paris) for the treatmentof melasma. There are several active ingredientsin licorice extract effective on melasma. These areliquiritin, glabridin, licochalcone A and isoliquertin.
Letter to Editor
Beuy Joob
Volume 16, Issue 3 , 2013, Pages 120-120
