G Sadeghian; MA Nilforoush Zadeh; M Motevali Emami
Volume 8, Issue 4 , 2005, Pages 251-255
Abstract
Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find ...
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Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find a more effective and safer drug is continuing. The objective of this study was to compare the effect of intra-lesional hypertonic sodium chloride solution and intra-lesional meglumine antimoniate injections in the treatment of cutaneous leishmaniasis.Materials and Methods: This randomized controlled clinical trial with simple sampling method was performed on 72 patients with cutaneous leishmaniasis. The patients were randomly divided in two groups. One group was treated with intra-lesional hypertonic sodium chloride solution and the other one was treated with intra-lesional meglumine antimoniate injections at weekly intervals for 6 to 10 weeks. All patients were followed for 6 months after treatment.Results: After six weeks of treatment, complete improvement, partial improvement, and no response to treatment were 33.3%, 45% and 22% in meglumine antimoniate group and 26%, 23% and 51% in trial group, respectively. In both groups complete improvement was observed in lesions smaller than 2 cm². In lesions with partial improvement the treatment was continued up to 10 weeks and all patients were followed for six months. After six months ultimate cure rate was 52% in meglumine antimoniate group and 25% in hypertonic sodium chloride solution group.Conclusion: Injections of hypertonic sodium chloride solution has less efficacy in comparison with intra-lesional meglumine antimoniate in treatment of cutaneous leishmaniasis, but considering the good response in primary small lesions, it can be used as an alternative therapy in some special cases including small lesions and allergic reactions to meglumine antimoniate.
P Toosi; A Sadiqha; H Monshi Zadeh; R Toosi
Volume 8, Issue 4 , 2005, Pages 256-259
Abstract
Background and objective: Oral isotretinoin is the only treatment that has an effect on all the major etiological factors involved in acne (Increased sebum production, alterations in microbial flora, hyperkeratinization of pilosebaceous duct, and inflammation). Considering complications and relative ...
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Background and objective: Oral isotretinoin is the only treatment that has an effect on all the major etiological factors involved in acne (Increased sebum production, alterations in microbial flora, hyperkeratinization of pilosebaceous duct, and inflammation). Considering complications and relative expense, several treatment regimens have been suggested. The objective of this study was to evaluate the efficacy of intermittent doses of isotretinoin in acne patients. Materials ad Methods: We made a quasi-experimental clinical trial in the acne patients without nodular and cystic lesions that were recalcitrant to conventional therapy. Therapeutic regimen included 0.5 mg/kg isotretinoin per day for a week every month; So we use 21 mg/kg as total dosage. Results: Acne severity decreased in entire patients at the end of treatment course. After six months follow up, recurrence rate was 19.3% and partially recurrence rate was 44%. Conclusion: It seems that intermittent isotretinoin treatment with a total dose of 21 mg/kg has led to good therapeutic results in patients without nodulocystic lesions.
M Bakhshi Zadeh; SH Hejazi; M Baghaei; F Jafari; Z Ghayour; A Khamesi Pour
Volume 8, Issue 4 , 2005, Pages 260-265
Abstract
Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate ...
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Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate the beneficial effects of a NO releasing cream on cutaneous leishmaniasis in an animal model. Materials and Methods: Balb/c mice were infected with leishmania major by injecting promastigotes into the base of tails of mice to induce the lesion. Then the animals were divided into 3 groups (Control, placebo and treatment). Mice were treated with the drugs one time daily. The diameter of lesions were measured on days 0, 5, 10, 15, 20, 25, and 30 after the appearance of the lesions. Data were analyzed using one-way ANOVA test and (P<0.05) considered as significant. Results: The diameter of lesions were significantly reduced in 15, 20, 25 and 30 day in NO cream treated animals compared to control and placebo groups (P<0.05). Conclusion: NO releasing compounds may be effective in the treatment of leishmaniasis.
S Nassiri; S Taghavian Pour; A Sadiqha
Volume 8, Issue 4 , 2005, Pages 266-271
Abstract
Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate ...
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Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate the relation between vertex type androgenetic alopecia (Grade III and higher according to Hamilton-Norwood) and hyperlipidemia.Materials and Methods: In this case-control study, lipid parameters (Total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, total cholesterol/HDL cholesterol ratio) of 50 men with vertex type androgenetic alopecia (Study group) were compared with 50 men with normal hair status (Control group). Study group matched according to the age, BMI and habit of smoking with control group.Results: Study group had a higher triglyceride and lower HDL cholesterol levels than control group. Total cholesterol/HDL cholesterol ratio was significantly higher in study group (P<0.05).Conclusion: Vertex type androgenetic alopecia could be a clinical marker of hyperlipidemia and dermatologists should investigate lipid profile in these patients.
M Danesh Pajouh; K Balighi; F Safar; M Asheghan; M Asadollahi; Gh.R Hassiri
Volume 8, Issue 4 , 2005, Pages 272-275
Abstract
Background and objective: Psoriasis is chronic inflammatory skin disorder with a wide variety of clinical presentations. Presence of anti-gliadin antibody (AGA) has been reported in 16% of psoriatic patients. This study was designed to determine the frequency of the presence of AGA in psoriatic patients. ...
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Background and objective: Psoriasis is chronic inflammatory skin disorder with a wide variety of clinical presentations. Presence of anti-gliadin antibody (AGA) has been reported in 16% of psoriatic patients. This study was designed to determine the frequency of the presence of AGA in psoriatic patients. Materials and Methods: After recording the demographic data and the severity of disease according to PASI scoring system, serum of 10 psoriatic patients and 100 healthy controls were studied for the presence of AGA using indirect innumofluorescence method. Results: AGA was present in sera of 4 (3 males and one female) psoriatic patient while all controls were negative. Three patients were from 20 to 40 years of age. All four AGA positive patients suffered from plaque type psoriasis. The disease severity was mild in one, moderate in two, and severe in one patient. None of them suffered from gastrointestinal problems. Conclusion: Although AGA may be present in the serum of some psoriatic cases, a significant relation between skin lesion and hypersensivity to gluten has not been determined yet. More studies using more specific and sensitive assessment methods and larger sample sizes are suggested.
R Salman Poor; M Mir Nezami
Volume 8, Issue 4 , 2005, Pages 276-280
Abstract
Background an objective: Renal transplantation may be considered as the only effective long-term therapy for chronic renal failure. Better surgical techniques and recent advances in immunosuppressive therapy allows patients to survive for many years. However, cutaneous lesions (Cosmetic, infectious, ...
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Background an objective: Renal transplantation may be considered as the only effective long-term therapy for chronic renal failure. Better surgical techniques and recent advances in immunosuppressive therapy allows patients to survive for many years. However, cutaneous lesions (Cosmetic, infectious, pre-cancerous and neoplastic) can be a significant problem for this group of patients. This study was performed to determine the frequency of skin lesions in renal transplant recipients (RTR) in Shiraz university of medical sciences in 2003-04. Materials and Methods: This descriptive study was done on RTR operated in transplantation center, Namazi hospital in Shiraz. They had a complete dermatologic history taken and received a thorough dermatologic examination in the department of dermatology at Faghihi hospital. Results: From July 2003 to October 2004 two hundred (130 males and 70 females) patients with a mean age of 39 years were studied. Hypertrichosis was the most commonly observed dermatologic conition, which was observed in 191 cases. The most common skin infection was wart presented in 101 cases. Eight patients had non-melanoma skin cancer. Conclusion: Awareness of RTRs and their medical personnel about cutaneous complications of renal transplantation as well as early referral of these patients to dermatologists to treat their lesions can improve their quality of life and survival.
MJ Yazdan Panah; M Ebrahimi Rad; MJ Mojahedi
Volume 8, Issue 4 , 2005, Pages 281-286
Abstract
Background and objective: Renal transplantation is an appropriate treatment for end stage renal disease and helps prolongation of patients survival with better quality, but immunosuppressive drugs that are used for inhibition of rejection after transplantation may cause some adverse effects in other ...
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Background and objective: Renal transplantation is an appropriate treatment for end stage renal disease and helps prolongation of patients survival with better quality, but immunosuppressive drugs that are used for inhibition of rejection after transplantation may cause some adverse effects in other organs such as the skin. Apparently, early recognition of those side effects and their appropriate management can reduce morbidity and mortality. This study was designed to study cutaneous complications in renal transplantation recipients. Materials and Methods: In this descriptive study cutaneous side effects in one hundred kidney transplant patients who admitted to transplantation clinics of Ghaem and Imam Reza hospital of Mashhad during a six-month period (April to September 2003) were studied. Results: Sixty-five patients were males and 35 cases were female. The mean age was 36 years (SD=14). Totally, cutaneous manifestations were observed in 88% of patients. In an descending order they included hypertrichosis, cushingoid appearance, gingival hypeplasia, steroid acne, common warts, herpes simplex infection, superficial fungal infection, candidiasis. Actinic keratosis, porokeratosis, lymphoma, stria, telangiectasia and sebaceous hyperplasia. Conclusion: Early recognition of these complications and appropriate treatment of them can reduce probable mortality and morbidity.
SZ Famili; SM Dadkhah; S Ebrahim Zadeh
Volume 8, Issue 4 , 2005, Pages 287-292
Abstract
Background and objective: Pityriasis rosea (PR) is a transient skin disease with a distinct appearance that is prevalent throughout the world and is more frequently seen in winter. Despite the reported epidemiological evidence, which account for an infective agent, this has not been proved, yet. This ...
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Background and objective: Pityriasis rosea (PR) is a transient skin disease with a distinct appearance that is prevalent throughout the world and is more frequently seen in winter. Despite the reported epidemiological evidence, which account for an infective agent, this has not been proved, yet. This study was designed to determine the epidemiological features of PR in terms of age, gender, seasonal, and clinical features. Materials and Methods: In this survery, age, gender, time of referring, history of common cold, herald patch location, itching, as well as clinical manifestations among 251 patients with PR referred to dermatology clinic of Ghaem hospital in Mashhad from October 2001 to March 2003 were studied. Results: The female/male ratio was 2.07/1. The largest breakout was observed among patients aged between 15-30 years. The majority of them referred in autumn (32.9%) in October (14.7%), and November (11.5%). 17.9% of patients complained of itching and 7.6% of patients had purpuric PR lesions. One-hundred and forty-six (58.2%) patients complained of a history of common cold two months prior to admission and the percentage of patients with common cold was 65.8% in fall and 64.2% in winter. Conclusion: Because of a large breakout of disease in winter and a high rate of common cold in cold seasons, more research still is needed to prove the infective etiological factor, particularly viral factors.
M Rahimi Nejad
Volume 8, Issue 4 , 2005, Pages 293-298
Abstract
Background and objective: Peel oil and juice of citrus fruits have furocoumarin (Psoralen) that can induce phytophotodermatitis. If the reaction is mild, then only hyperpigmentation (Without itching, burning, erythema, vesicle and bullae, formation) may occur. The objective of this study was to describe ...
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Background and objective: Peel oil and juice of citrus fruits have furocoumarin (Psoralen) that can induce phytophotodermatitis. If the reaction is mild, then only hyperpigmentation (Without itching, burning, erythema, vesicle and bullae, formation) may occur. The objective of this study was to describe the patients with hyperpigmentation of back of the hands. Materials and Methods: Thirty-two patients with hyperpigmentation of back of hands (Especially between fingers) referred to a dermatologic clinic in Jahrom from 31 December to May 6, 2004, were studied. Results: All of these patients were female and their mean age was 21.4 years. Patients did not complained of itching and burning and there was no history of erythema, vesicle or bullae formation before appearance of hyperpigmentation. 31 patients (97%) took sour orange juice with hands. Out of them, 16 patients (50%) took a lot sour orange juice several days (With mean tine of 7.6 days) before appearance of hyperpigmentation, 8 patients (75%) took only sour orange juice intermittently and 7 patients (22%) took intermittently rough lemon and orange juice in addition to sour orange and only in one patient (3%), the lesions developed about one week after taking rough lemon juice with hands. Conclusion: Phytophotodermatitis secondary to contact with citrus fruit juice may result in hyperpigmentation of back of the hands.
A Rasi; H Ansarin; AR Khatami
Volume 8, Issue 4 , 2005, Pages 299-306
Abstract
Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, ...
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Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathic thrombocytopenic purpura. IVIg treatment has been shown to be safe, without many drug-related adverse effects, including systemic immunosuppression, that are related to corticosteriods and other immunosuppressive agents. Current dermatologic uses of IVIg are increasing, which calls for adequately controlled clinical trials. This review evaluates the current published data on the use of IVIg therapy in the treatment of autoimmune diseases and discusses current opinion concerning its potential immunomodulating mechanisms, the industrial preparation and safety features of this biologic agent.
N Farsi; M Mandegar Fard
Volume 8, Issue 4 , 2005, Pages 307-310
Abstract
Lymphangioma circumscriptum is a congenital lymphatic malformation that results in gradual dilatation of lymphatic vessels and development of lymphatic cisterns. The treatment of choice is radical surgery. Other treatment methods including cryotherapy, sclerosing agent injections, radiation therapy and ...
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Lymphangioma circumscriptum is a congenital lymphatic malformation that results in gradual dilatation of lymphatic vessels and development of lymphatic cisterns. The treatment of choice is radical surgery. Other treatment methods including cryotherapy, sclerosing agent injections, radiation therapy and CO2 laser were suggested. We report successful treatment of a 14-year-old boy affected with lymphangioma with CO2 laser.
MH Davami; A Kiani; M Salimi; E Farhadi
Volume 8, Issue 4 , 2005, Pages 311-315
Abstract
Myiasis is the invasion of animal or human tissues by the larval stage of flies (Diptera). It is an accidental infestation in human. In this report a rural fifty-six-year old patient with myiasis on the scalp is presented. He was referred to clinic with a mass on his left temporo-occipital area. There ...
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Myiasis is the invasion of animal or human tissues by the larval stage of flies (Diptera). It is an accidental infestation in human. In this report a rural fifty-six-year old patient with myiasis on the scalp is presented. He was referred to clinic with a mass on his left temporo-occipital area. There was no history of trauma to his head or presence of ulcer on his scalp. In physical examination an ulcer sized 2×3 centimeters full of larvae was observed. The diagnosis of myiasis was made. Larvae were removed, tetanus vaccine was inoculated and oral antibiotics were prescribed. Parasitological examination determined the causative agent as chrysomya bezziana.
S Zandi; N Adibi; S Shamsadini
Volume 8, Issue 4 , 2005, Pages 316-321
Abstract
Hutchinson-Gilford progeria syndrome is an extremely rare condition with features of premature and accelerated aging. The pattern of inheritance is unclear, although autosomal dominant mutations have been proposed. The disease presentation is usually in infancy and early childhood with a characteristic ...
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Hutchinson-Gilford progeria syndrome is an extremely rare condition with features of premature and accelerated aging. The pattern of inheritance is unclear, although autosomal dominant mutations have been proposed. The disease presentation is usually in infancy and early childhood with a characteristic phenotype of short stature, abnormal skin and nail, beaked nose, loss of subcutaneous fat, failure to thrive, varying degrees of alopecia and premature graying of hair and prominent scalp veins. Laboratory and pathological findings are not characteristic and death results from cardiovascular abnormalities usually in the second decade of life in the majority of cases. We report a four-year-old boy who came to our hospital with history of mottled pigmentation of skin and abnormal facies. Due to clinical features and pathological data, the case was diagnosed as Hutchinson gilfored progeria syndrome.
