Iranian Journal of Dermatology

Abstract Primary cutaneous CD30+ T cell lymphoma is rare lymphoma originally in and confined to the skin. These lymphomas usually present as a large solitary and often ulcerated nodule. Its prognosis is a good and has a good response to radiotherapy. We report a 34- year- old man who had primary cutaneous CD30+T cell lymphoma on his face, which presented as an ulcerated nodule.

Abstract Porokeratosis of Mibelli is a keratinization disorder due to cellular clones that show different degress of dysplasia. Sometimes, these lesions develop on the previously traumatized or burnt skin. Herein, a 24 – year- old female patient is presented with three facial skin lesions on her right cheek on a previous old scar due to cutaneous leishmaniasis is presented. The larger lesion was an erythematosquamous plaque with a well – defined hyperkeratotic margin and an atrophic center and two smaller erythematosquamous papules were located about 1.5 centimeter away from the main lesion. In the histopathologic evaluation of the skin biopsy of the patient, hyerkeratosis, irregular acanthosis and the characteristic column of parakeratotic cells (cornoid lamella) were evident. Considering clinical appearance of the lesion as well as the histopathologic findings, the patients was diagnosed as case of porokeratosis of Mibelli that was developed on an old scar due to cutaneous leishmaniasis.

Abstract Epidermal nevi are cutaneous hamartomas developing from ectoderm and one of their types is verrucous epidermal nevus. During the neonatal period, they are pink or slightly pigmented and velvety. Later, they darken and the surface become more warty. When lesions are distributed on one side of body, it is termed nevus unis lateralis. Lymphangioma is a lymphatic malformation which manifests with fluid- filled vesicles bulged on the skin surface.We present a 30- year – old man with pigmented, hyperkeratotic plaques on right side of his body associated with clear vesicles predominant at right side of his natal cleft. The histopathologic report of above lesions were epidermal nevus and lymphangioma, respectively.

Abstract Dowling –Degos disease is a rare condition. It is inherited by an autosomal dominant gene. It usually presents in adult life as small, pigmented, asymptomatic macules in flexural regions. We report a 35-year-old woman with Dowling- Degos disease, in whom the reticular pigmentation confined to the genital area.

Abstract This is a report of a 40- year- old woman presented to our outpatient dermatology clinic. She had a 40- day history of sudden development of skin lesions on the exposed. Dermatologic examination revealed relatively limited brown – reddish plaques on the hands, feet, face, one elbow and groin regions. She has been taking carbamazepine (200 mg/ day) for 13 years. Otherwise, no serious problems were found. A clinical diagnosis of drug- induced pellagra was made based on the morphology. After discontinuing carbamazepine, treatment with nicotinamide (500 mg/day) was initiated and the eruption faded away and resolved within 3 weeks. Pellagra is a disease caused by a deficiency of the niacin and may occur with certain drugs.

Abstract Eosinophilic cellulitis is a rare skin disorder may be idiopathic or be associated with other conditions. We present a 42- year- old female patient with bilateral atypical cellulitis – like lesions on her arms. The patient had a documented infection with Leptospira recently, and had a positive history for fascioliasis two years before.
Histopathology examination of the lesion was compatible with the acute phase of the Wells' syndrome. We review the related diseases of this syndrome and discuss the possible associations in this patient.

Abstract Lipoid proteinosis, a rare autosomal recessive disorder, presents in early childhood with hoarseness, skin infiltration and thickening, beaded papules on eyelid margins, and facial acneiform or pock- like scars. Although

Abstract Several skin conditions have been reported to occur on epidermal nevi, but it seems that co-occurrence of a vascular lesion and an epidermal nevus is a very rare phenomenon. Herein, a 17- year- old female patient who had presented with skin lesions on her thigh since 4 years ago has been reported. The lesions were two oval plaques consisted of multiple brown- tinted, hyperkereratotic papules that surrounded several dark red papules. One of the lesions was totally excised and the specimen was sent for histopathologic evalution. Routine light microscopic examination of the slides revealed histopathologic features of both epidermal nevus and angiokeratoma. The clinical presentation of this case suggested the co- occurrence of an epidermal nevus and angiokeratoma, which was confirmed after histopathological study.

Abstract Basal cell carcinoma (BCC) is a malignant tumor of epithelial cells that is composed of cells similar to those in the basal area of the epidermis and its appendages. Ninety- five percent of individuals with BCC are between 40 and 79 years old. It rarely occurs in younger individuals. Herein, a 20- year- old woman with type III skin, who had a BCC on her chin is presented. Since the clinical features and age of onset of this lesion were not typical for BCC , correct diagnosis was confirmed by histological examination.

Abstract Pulsed dye laser (PDL) is an effective treatment for port- wine stain and can cause some short- term and long- term side- effects. Pyogenic granoluma is one of its late- onset adverse effects. Herein, we present two cases of pyogenic granoluma following treatment of port- wine stain with PDL.

Abstract Epidermolysis bullosa are a group of hereditary skin diseases manifested as blisters on the sites of trauma to the skin. According to the level of blister development, epidermolysis bullosa are divided into the following groups: epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic epidermolysis bullosa. The latter two groups are associated with poorer prognosis and higher mortality and morbidity in comparison with the first group due to the mucosal involvement and associated anomalies in other organs. The presented case was a neonate whom was presented with several blisters and erosions on skin since birth as well as clinical findings suggesting stomach outlet obstruction. It is important to evaluate neonates with epidermolysis bullosa for presence of probable associated anomalies.

Abstract Port- wine stain is a congenital vascular malformation originating from superficial dermal vessels which is characterized by ectasia of the capillaries. Currently, pulsed dye laser (PDL) is used to treat these vascular lesions. To date, there are few reports of eczematous lesions due to PDL. Herein, we report three cases of eczema following PDL, used for treatment of port- wine stain in Razi hospital. Dermatitis following laser therapy is not frequent but may be seen occasionally. Therefore, Patients should be informed on the possibility of this adverse effect before instituting the treatment.

Abstract Nowadays, Erbium: YAG laser resurfacing of periorbital skin has become a very popular method of wrinkle reduction. Seven patients with Fitzpatrick skin phototypes of II to V were treated with a 2940 nm Erbium: YAG laser system for resurfacing of periorbital wrinkles. Photographic evalution performed before and after treatment. Patients were visited at 1,2,3,5,7,14,30 and 60 days after laser resurfacing. The results were graded into five categories: no improvement (grade 0), mild (grade 1: up to 25% ), moderate (grade 2: 25-50%), good (grade 3: 50-75%) or excellent (grade 4: 75-100%). Two independent investigators and also the patients themselves evaluated the improvement grades by comparing the photographs. Peri- orbital skin re- epithelization after treatment took a mean duration of 3.7 days. Duration of erythema varied from two to seven weeks with a mean duration of 16.2 days. Eight weeks after the end of the treatment the mean improvement grade was 2.35 (moderate to good) by investigators judgment and 2.14 (moderate to good) by the patients themselves. No pigmentary complications were evident after 8 weeks. No scars or ectropion were observed.

Abstract Eruptive vellus hair cysts are disorders that present as cystic papules usually on the chest and extremities. Facial involvement is very rare in this disorder and few reports of facial eruptive vellus hair cysts have been presented till now.We present two cases of eruptive vellus hair cysts in a mother and her daughter with facial distribution.

Abstract Orf is a disease caused by parapoxviruses. Infection is transmitted to human from animals like sheep and goats, Herein, we report a 47- year- old man with fourteen lesions on different parts of his right hand, while usually the lesion is single and up to a maximum of ten lesions have been reported previously.

Abstract Between 20% and 35% of patients with systemic sarcoidosis have skin lesions. One of the unusual cutaneous presentations of sarcoidosis is a granulomatous tattoo reaction that may present alone or with other features of sarcoidosis. We present a case of sarcoidosis whom presented with multiple nodules on tattood skin accompanied with facial pulsy, parotid enlargement and uveitis.